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Q75B12

- ALG11_ASHGO

UniProt

Q75B12 - ALG11_ASHGO

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. oligosaccharide-lipid intermediate biosynthetic process Source: EnsemblFungi
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Alpha-1,2-mannosyltransferase ALG11
    Asparagine-linked glycosylation protein 11
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:ALG11
    Ordered Locus Names:ADL235W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome IV

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080272Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_ADL235W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75B12.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 582549LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi139 – 1424Poly-Gly

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000209670.
    KOiK03844.
    OMAiHPYANNG.
    OrthoDBiEOG7673KQ.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75B12-1 [UniParc]FASTAAdd to Basket

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    MESCWLTMES YQAALVVCIV SGLILAVAGY GNVRRLACEF LLKPPKRFRD    50
    DICEALLRGP ENDQKPVLVD FGWRHGAVRR QMLLASAKAS AYSNERHGSK 100
    IHISPDDIAR GRSFADALDV HRRSGRILFG FFHPFCNAGG GGEKVLWKAV 150
    ETTLKQSLNN IVVVYTGDCD TTGARILSNV EHRFGSQLDS ERIVFIFLRH 200
    RKWVESRTWP RMTLLGQALG SIVLSIEAAL CCPPDVWCDT MGYPFGYPFV 250
    SWLCRIPIIT YTHYPVVSID MLDKLRMMPE FRNSPTLWAK FLYWRIFMRC 300
    YTFAGSFVDL AVTNSTWTYN HINAIWSRTG NVSIIYPPCS TENLVIENAH 350
    DMWDRKHQAV VIAQFRPEKR HALILRSFSN FVKKTGSNMK LLMLGSTRGQ 400
    EDRDYVKKLE QLAYSELAIP KESLEFITDC KYEKMKKYLQ ESSFGINAMW 450
    NEHFGIAVVE YAASGLITLA HASAGPLLDI IVPWDIEGDK QLERGSDKNR 500
    TGFFFKDRSD PDFCKITAEF PTLEELFVRA DQLTDEERLA ISQRAKRCVL 550
    HKFSDLKFSE DWAQVVDRTI QLLHTLRNDK VE 582
    Length:582
    Mass (Da):66,635
    Last modified:July 5, 2004 - v1
    Checksum:iBE8C12857524068E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016817 Genomic DNA. Translation: AAS51685.1.
    RefSeqiNP_983861.1. NM_209214.1.

    Genome annotation databases

    EnsemblFungiiAAS51685; AAS51685; AGOS_ADL235W.
    GeneIDi4619996.
    KEGGiago:AGOS_ADL235W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016817 Genomic DNA. Translation: AAS51685.1 .
    RefSeqi NP_983861.1. NM_209214.1.

    3D structure databases

    ProteinModelPortali Q75B12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_ADL235W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS51685 ; AAS51685 ; AGOS_ADL235W .
    GeneIDi 4619996.
    KEGGi ago:AGOS_ADL235W.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000209670.
    KOi K03844.
    OMAi HPYANNG.
    OrthoDBi EOG7673KQ.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiALG11_ASHGO
    AccessioniPrimary (citable) accession number: Q75B12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3