Reviewed,
UniProtKB/Swiss-Prot Q75B10 (LKHA4_ASHGO)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Leukotriene A-4 hydrolase EC=3.3.2.6 Alternative name(s): Leukotriene A(4) hydrolase Short name=LTA-4 hydrolase | ||||
| Gene names |
| ||||
| Organism | Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome] | ||||
| Taxonomic identifier | 33169 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium |
Protein attributes
| Sequence length | 623 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Hydrolyzes an epoxide moiety of LTA4 to form LTB4. The enzyme also has some peptidase activity By similarity. |
| Catalytic activity | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase M1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Leukotriene biosynthesis |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Metalloprotease Protease |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | leukotriene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | leukotriene-A4 hydrolase activity Inferred from electronic annotation. Source: EC metallopeptidase activityInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 623 | 623 | Leukotriene A-4 hydrolase | PRO_0000324917 | |||||
Sites | |||||||||
| Active site | 296 | 1 | By similarity | ||||||
| Active site | 382 | 1 | Proton donor By similarity | ||||||
| Metal binding | 295 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 299 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 318 | 1 | Zinc; catalytic By similarity | ||||||
| Site | 199 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016817 Genomic DNA. Translation: AAS51687.1. |
| RefSeq | NP_983863.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HS6 based on UniProtKB P09960. |
| SMR | Q75B10. Positions 14-623. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q75B10. |
Genome annotation databases | |
| GeneID | 4619998. |
| GenomeReviews | Gene locus ADL233W in contig AE016817_GR. |
| KEGG | ago:AGOS_ADL233W. |
| NMPDR | fig|33169.1.peg.1508. |
Organism-specific databases | |
| AGD | ADL233W. |
Phylogenomic databases | |
| eggNOG | fuNOG04031. |
| HOGENOM | HBG444814. |
| OMA | FTNRIVE. |
| OrthoDB | EOG92RFQK. |
Enzyme and pathway databases | |
| BRENDA | 3.3.2.6. 279361. |
Family and domain databases | |
| InterPro | IPR016024. ARM-type_fold. IPR001930. Peptidase_M1. IPR015211. Peptidase_M1_C. IPR014782. Peptidase_M1_N. [Graphical view] |
| PANTHER | PTHR11533. Peptidase_M1. 1 hit. |
| Pfam | PF09127. Leuk-A4-hydro_C. 1 hit. PF01433. Peptidase_M1. 1 hit. [Graphical view] |
| PRINTS | PR00756. ALADIPTASE. |
| PROSITE | PS00142. ZINC_PROTEASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LKHA4_ASHGO | ||||||||
| Accession | Primary (citable) accession number: Q75B10 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


