Reviewed, UniProtKB/Swiss-Prot Q75AW1 (ARGD_ASHGO)

Names and origin

Protein names

Recommended name:
    Acetylornithine aminotransferase, mitochondrial
      Short name=ACOAT
    EC=2.6.1.11

Gene names

Name:	ARG8
Ordered Locus Names:	ADL191W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 423		Acetylornithine aminotransferase, mitochondrial		PRO_0000002076
Amino acid modifications
	Modified residue	276	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75AW1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BF6D07FEC096BCBB	FASTA	423	46,111
	10 20 30 40 50 60 MVNQRVVHLC AKRSFSLTAS MQKYFVDVYA KPDLVLTRGR GSRLFDDVNK REYIDFVAGI 70 80 90 100 110 120 AVTSLGHSDP AIAEVIAAQS ATLVHTSNLF HNSEALKFAE KLVESTKRFG GQQDAEKVYF 130 140 150 160 170 180 CNSGTEANEA ALKFSRRRAL RTDPQKQGFI AFENSFHGRT MGSLSVTSKA KYRLPFGDMV 190 200 210 220 230 240 PHVTFLNIHD PVEKLVSFIV ENAPKTAAMI LEPIQGEGGV HRVPEDKLVA LGRLCKKHDI 250 260 270 280 290 300 VLIYDEIQCG LGRTGKLWAH SNLPADAHPD IFTTAKALGN GFPMGATVVN SKVNEVLSVG 310 320 330 340 350 360 DHGTTYGGNP LACAVGNHVL DRIAQQPFLD DVKAKANVFT AGLLALQKKY PFIREIRGDG 370 380 390 400 410 420 LLIGVEFTVD VSDIISKSRE RGLLITAAGP NTLRIIPALT IEEDTIRQGL EILESVVGEI SSS

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016817 Genomic DNA. Translation: AAS51729.1.
RefSeq	NP_983905.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q75AW1.
Genome annotation databases
GeneID	4620047.
GenomeReviews	Gene locus ADL191W in contig AE016817_GR.
KEGG	ago:AGOS_ADL191W.
NMPDR	fig|33169.1.peg.1550.
Organism-specific databases
AGD	ADL191W.
Phylogenomic databases
HOGENOM	Q75AW1.
OMA	TTYARPN.
Enzyme and pathway databases
BRENDA	2.6.1.11. 279361.
Family and domain databases
InterPro	IPR004636. AcOrn/succinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00707. argD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGD_ASHGO

Accession

Primary (citable) accession number: Q75AW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)