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Protein

Eukaryotic translation initiation factor 4E

Gene

TIF45

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E
Short name:
eIF-4E
Short name:
eIF4E
Alternative name(s):
eIF-4F 25 kDa subunit
mRNA cap-binding protein
Gene namesi
Name:TIF45
Ordered Locus Names:ADL188C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001936481 – 211Eukaryotic translation initiation factor 4EAdd BLAST211

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186751.
InParanoidiQ75AV8.
KOiK03259.
OMAiTEDICGI.
OrthoDBiEOG092C4INY.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75AV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEEVTQKA QALSVGDNEE RKTVLTDSKD FDLKHPLNSK WTLWYTKPPV
60 70 80 90 100
GDNESWSDLL RPVTSFTTVE EFWAIQNAIP KPRELPLKSD YHLFRNDIRP
110 120 130 140 150
EWEDEANSRG GKWSFQFKVR NPPIDDLWLR ALLAVIGESI DEDESEINGV
160 170 180 190 200
VINVRRSGFK IGLWTKSVRQ APLSKVGAKF KAVLQLDDSD TLEFFAHSSA
210
NDKNAKPALV L
Length:211
Mass (Da):24,025
Last modified:January 9, 2013 - v2
Checksum:iC12F7537858A29CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS51732.2.
RefSeqiNP_983908.2. NM_209261.2.

Genome annotation databases

EnsemblFungiiAAS51732; AAS51732; AGOS_ADL188C.
GeneIDi4620050.
KEGGiago:AGOS_ADL188C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS51732.2.
RefSeqiNP_983908.2. NM_209261.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS51732; AAS51732; AGOS_ADL188C.
GeneIDi4620050.
KEGGiago:AGOS_ADL188C.

Phylogenomic databases

HOGENOMiHOG000186751.
InParanoidiQ75AV8.
KOiK03259.
OMAiTEDICGI.
OrthoDBiEOG092C4INY.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF4E_ASHGO
AccessioniPrimary (citable) accession number: Q75AV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 9, 2013
Last modified: September 7, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.