Q75AP1 (HIS4_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	HIS6
Ordered Locus Names:	ADL121W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase		PRO_0000141955

Sequences

	Sequence		Length	Mass (Da)
	Q75AP1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F812A5FED806087B	FASTA	263	28,431
	10 20 30 40 50 60 MTRFVGCIDL HDGKVKQIVG GTLSSKPDGE APVTNFVSDK SPSHYAHLYA SNDVQGSHVI 70 80 90 100 110 120 RLGQSNDEAA LMALQAAPGF LQLGGGVTKD NCQYWLQWAS KVIVTSALFD SDGSFQLQRL 130 140 150 160 170 180 REISGLCGRA RLVVDLSCRR ASDGASWTVM MNKWQTPTTL ALNEETLALL SEYCSEFLIH 190 200 210 220 230 240 AADVEGLCRG IDEELVAQLG LWAAQLRGDV RVVYAGGANS VADLGLVKRL SGGRVDLTYG 250 260 SALDIFGGSL VRFQDCCAWN RQQ

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016817 Genomic DNA. Translation: AAS51799.1.
RefSeq	NP_983975.1. NM_209328.1.
3D structure databases
ProteinModelPortal	Q75AP1.
SMR	Q75AP1. Positions 2-263.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_ADL121W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	AAS51799; AAS51799; AGOS_ADL121W.
GeneID	4620118.
KEGG	ago:AGOS_ADL121W.
Phylogenomic databases
eggNOG	COG0106.
HOGENOM	HOG000172261.
KO	K01814.
OMA	VAMNKWQ.
OrthoDB	EOG4XH389.
PhylomeDB	Q75AP1.
Enzyme and pathway databases
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR011858. HisA_euk. IPR011060. RibuloseP-bd_barrel. [Graphical view]
PANTHER	PTHR21169. PTHR21169. 1 hit.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR02129. hisA_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_ASHGO

Accession

Primary (citable) accession number: Q75AP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program