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Q75AL5 (JHD1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
JmjC domain-containing histone demethylation protein 1
EC=1.14.11.27
Alternative name(s):
[Histone-H3]-lysine-36 demethylase 1
Gene names
Name:JHD1
Ordered Locus Names:ADL088W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.

Catalytic activity

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.

Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Domain

The JmjC domain mediates the demethylation activity By similarity.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Contains 1 JmjC domain.

Contains 1 PHD-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486JmjC domain-containing histone demethylation protein 1
PRO_0000226791

Regions

Domain245 – 404160JmjC
Zinc finger28 – 8356PHD-type; degenerate

Sites

Metal binding3001Iron; catalytic By similarity
Metal binding3021Iron; catalytic By similarity
Metal binding3721Iron; catalytic By similarity
Binding site2971Substrate By similarity
Binding site3171Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q75AL5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 53A9F8861DCACDC7

FASTA48655,076
        10         20         30         40         50         60 
MLQQVTSTTV TGADIQLRAK LLLFSMTDDQ CVYCKGKMEH RMWVQCEACP QWVHVQCIPE 

        70         80         90        100        110        120 
ECLSGGEYPS RSSDIAAFEC SAHGTARARL ALKGKRRRVE AKEEPERAGT RRYRLRKRGP 

       130        140        150        160        170        180 
LDYIALNEGQ DVRLRHEHPH RAAFQGCFTK WSGLGRTVTS AELQQSFAEL REPVLVADPE 

       190        200        210        220        230        240 
HSGMQTPAMD EQVLADVLGA DYSLDVMDVQ SQQNERWTMG QWKEYMHTAR GVRDRIRNVI 

       250        260        270        280        290        300 
SLEVSHVPEF GQRIRRPRAV EDNDLVDLVW PVQPAPEIGA KPKVQKYVLM SAANAYTDFH 

       310        320        330        340        350        360 
LDFAGTSVYY SLLRGAKQFL LFPPTPANLG AYKAWCADDN QGLIFLGDRL QDGVLFSLRP 

       370        380        390        400        410        420 
GDLFMIPSGF IHAVYTPEDS FVVGGNYLCL RDLSTHIRIV RIEQETQVPK KFTFPKFERV 

       430        440        450        460        470        480 
MGLTAEWLLE GLPERLQLIT HEHAVALLDY LRDTRLKYKP AHYHTKSTML ASLEKALEGC 


EPASGP

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References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016817 Genomic DNA. Translation: AAS51832.1.
RefSeqNP_984008.2. NM_209361.2.

3D structure databases

ProteinModelPortalQ75AL5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ75AL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4620150.
GenomeReviewsGene locus ADL088W in contig AE016817_GR.
KEGGago:AGOS_ADL088W.
NMPDRfig|33169.1.peg.1653.

Organism-specific databases

AGDADL088W.

Phylogenomic databases

eggNOGfuNOG04730.
HOGENOMHBG398146.
OMAISLEVSH.
OrthoDBEOG4SXRNC.
PhylomeDBQ75AL5.

Family and domain databases

InterProIPR003347. TF_JmjC_AAH.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK10276.
SMARTSM00558. JmjC. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS51184. JMJC. 1 hit.
PS01359. ZF_PHD_1. False negative.
PS50016. ZF_PHD_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJHD1_ASHGO
AccessionPrimary (citable) accession number: Q75AL5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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