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Protein

Mitochondrial aspartate-glutamate transporter AGC1

Gene

AGC1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial aspartate-glutamate transporter AGC1
Alternative name(s):
Aspartate-glutamate carrier 1
Gene namesi
Name:AGC1
Ordered Locus Names:ADL049W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei524 – 544Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei584 – 604Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei621 – 641Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei663 – 683Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei723 – 743Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei778 – 798Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276001 – 911Mitochondrial aspartate-glutamate transporter AGC1Add BLAST911

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS51871.

Structurei

3D structure databases

ProteinModelPortaliQ75AH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati521 – 607Solcar 1Add BLAST87
Repeati615 – 702Solcar 2Add BLAST88
Repeati717 – 805Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000180633.
InParanoidiQ75AH6.
KOiK15105.
OMAiYYYKSCQ.
OrthoDBiEOG092C0E6C.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q75AH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSSASTVK KKRQLAIFNA YATPLRQDER RLRASYEHGG VVGGHVASNE
60 70 80 90 100
KVLLFDDFVD LISNSRSFYS KFTDHCFNLN QIPNTVFGCI FFAIDENNKG
110 120 130 140 150
YLNVNDWFYF NNVLEYDNYH FIILYEFFRK FDAARERAYG PSVKSINYGN
160 170 180 190 200
RFLSFDELYL DLEQFQATLR LLHSCVRDDF IVNNKLFLDW KQFRWLKWYQ
210 220 230 240 250
FYPRGLLQNG PHITLNSLIS IVQNDLKSEK LLLGFHCLSQ LDHRTNSMTI
260 270 280 290 300
SKNQLVYLMR LFYSHKIPAD IFNSLNMSTL SCAKCDNNHI NYNVFRDLFY
310 320 330 340 350
LIQNFDLLNQ IVHRYAEVHK FSDRDVREQH ISRKDLLRFM NTEYNKINNI
360 370 380 390 400
IEFSPAQISL LFSIVTNSKK LNYLNNARQN NPELSYHHRD SEIDSFIHNE
410 420 430 440 450
YINGNAASSL HNESLEKFND DFENIIQADA GDTKQQISST DWRSVFSWSS
460 470 480 490 500
FLSSFEWLHF KKRKSVQTNG LSDEYVNEAL TLEDIMKIVN PNYLNDLVHH
510 520 530 540 550
MELRRIESES RSSNLYFYPI FDSIYNFTLG SVAGCIGAMV VYPIDMVKTR
560 570 580 590 600
MQAQRDFSKY KNSIDCLLKI LSKEGVRGLY SGLGPQLIGV APEKAIKLTV
610 620 630 640 650
NDHMRATLAG RDGKLSLPCE IISGATAGAC QVVFTNPLEI VKIRLQVKSD
660 670 680 690 700
YVADAARNSV NAISVIKNLG LIGLYRGAGA CLLRDIPFSA IYFPTYAHIK
710 720 730 740 750
SNVFNFDPKD SDKRNKLNTW QLLVSGGLAG MPAAFLTTPF DVIKTRLQID
760 770 780 790 800
PKKGESVYNG IWDAARTILK EEGIKSFFKG GPARVLRSSP QFGFTLAAYE
810 820 830 840 850
IFHNLFPAPR YDDSTTHRPT REPVGALAPI NKTVSAFFPD QLEPHVGNNK
860 870 880 890 900
WASRLYGPNI DPYSSSFLNY YYKSCQVAKA FMDLDYNFAH FDFNTYQQFH
910
DELNAMKNKK H
Length:911
Mass (Da):104,906
Last modified:March 21, 2006 - v2
Checksum:iFB488859EE0A2C4B
GO

Sequence cautioni

The sequence AAS51871 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS51871.1. Different initiation.
RefSeqiNP_984047.1. NM_209400.1.

Genome annotation databases

GeneIDi4620195.
KEGGiago:AGOS_ADL049W.

Similar proteinsi

Entry informationi

Entry nameiAGC1_ASHGO
AccessioniPrimary (citable) accession number: Q75AH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families