Reviewed,
UniProtKB/Swiss-Prot Q75AB5 (MPI_ASHGO)
Last modified
November 3, 2009.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannose-6-phosphate isomerase EC=5.3.1.8 Alternative name(s): Phosphomannose isomerase Short name=PMI Phosphohexomutase | ||||||
| Gene names |
| ||||||
| Organism | Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome] | ||||||
| Taxonomic identifier | 33169 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium |
Protein attributes
| Sequence length | 429 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity. |
| Catalytic activity | D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the mannose-6-phosphate isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding Zinc |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 429 | 429 | Mannose-6-phosphate isomerase | PRO_0000194239 | |||||
Sites | |||||||||
| Active site | 300 | 1 | By similarity | ||||||
| Metal binding | 109 | 1 | Zinc By similarity | ||||||
| Metal binding | 111 | 1 | Zinc By similarity | ||||||
| Metal binding | 136 | 1 | Zinc By similarity | ||||||
| Metal binding | 281 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51. |
Cross-references
Sequence databases | |
|---|---|
| AE016817 Genomic DNA. Translation: AAS51923.1. | |
| RefSeq | NP_984099.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q75AB5. |
Genome annotation databases | |
| GeneID | 4620247. |
| GenomeReviews | Gene locus ADR003C in contig AE016817_GR. |
| KEGG | ago:AGOS_ADR003C. |
| NMPDR | fig|33169.1.peg.1744. |
Organism-specific databases | |
| AGD | ADR003C. |
Phylogenomic databases | |
| HOGENOM | Q75AB5. |
| OMA | VGTHANG. |
Enzyme and pathway databases | |
| BRENDA | 5.3.1.8. 279361. |
Family and domain databases | |
| InterPro | IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits. |
| Pfam | PF01238. PMI_typeI. 1 hit. [Graphical view] |
| PIRSF | PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit. |
| PRINTS | PR00714. MAN6PISMRASE. |
| TIGRFAMs | TIGR00218. manA. 1 hit. |
| PROSITE | PS00965. PMI_I_1. 1 hit. PS00966. PMI_I_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPI_ASHGO | ||||||||
| Accession | Primary (citable) accession number: Q75AB5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


