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Q75AB5

- MPI_ASHGO

UniProt

Q75AB5 - MPI_ASHGO

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Protein

Mannose-6-phosphate isomerase

Gene
PMI1, PMI40, ADR003C
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Zinc By similarity
Metal bindingi111 – 1111Zinc By similarity
Metal bindingi136 – 1361Zinc By similarity
Metal bindingi281 – 2811Zinc By similarity
Active sitei300 – 3001 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:PMI1
Synonyms:PMI40
Ordered Locus Names:ADR003C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome IV

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Mannose-6-phosphate isomerasePRO_0000194239Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ADR003C.

Structurei

3D structure databases

ProteinModelPortaliQ75AB5.
SMRiQ75AB5. Positions 2-427.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
HOGENOMiHOG000241277.
KOiK01809.
OMAiPYAEFWV.
OrthoDBiEOG7WDNCR.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75AB5-1 [UniParc]FASTAAdd to Basket

« Hide

MSAKLFRLDA GYQQYDWGKI GSSSAVAQYA ANSDPSVQIE EDKPYAELWM    50
GTHHKVPSRH HDTKVALSDL IAANPEGMLG SGNVEKFHSR KDLPFLFKVL 100
SIEKVLSIQA HPDKNLGRRL HIQDPKNYPD DNHKPEMAIA ISDFEGFCGF 150
KPLEELAEEL QRIPEFRSLV GEDIAAQFCA GIKVGAQEGS EEDKSNRKLL 200
QSVFSNVMNA SDDVIASHAR HLVERAKQSP ADFNNETLPA LILRLNEQFP 250
EDVGLFCGCL MLNHCVLKAG ESIFLRAKDP HAYITGDIIE CMAASDNVVR 300
AGFTPKFKDV KNLVEMLTYS YDSVEDQKMK LLPFARSSGS GDSILYNPPI 350
EEFAVLQTNF HGSTGTHHFD GLDGPSIVIT TNGSGYIQSG DVRLKAEAGY 400
VFFIAPHAEV DLQTEDSNFT TYRAFVEPN 429
Length:429
Mass (Da):47,530
Last modified:July 5, 2004 - v1
Checksum:i7755EF1BC22F072A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS51923.1.
RefSeqiNP_984099.1. NM_209452.1.

Genome annotation databases

EnsemblFungiiAAS51923; AAS51923; AGOS_ADR003C.
GeneIDi4620247.
KEGGiago:AGOS_ADR003C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS51923.1 .
RefSeqi NP_984099.1. NM_209452.1.

3D structure databases

ProteinModelPortali Q75AB5.
SMRi Q75AB5. Positions 2-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ADR003C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS51923 ; AAS51923 ; AGOS_ADR003C .
GeneIDi 4620247.
KEGGi ago:AGOS_ADR003C.

Phylogenomic databases

eggNOGi COG1482.
HOGENOMi HOG000241277.
KOi K01809.
OMAi PYAEFWV.
OrthoDBi EOG7WDNCR.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiMPI_ASHGO
AccessioniPrimary (citable) accession number: Q75AB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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