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Protein

Mannose-6-phosphate isomerase

Gene

PMI1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (PMI1)
  2. Phosphomannomutase (AGOS_ABR236W)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincBy similarity1
Metal bindingi111ZincBy similarity1
Metal bindingi136ZincBy similarity1
Metal bindingi281ZincBy similarity1
Active sitei300By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:PMI1
Synonyms:PMI40
Ordered Locus Names:ADR003C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942391 – 429Mannose-6-phosphate isomeraseAdd BLAST429

Proteomic databases

PRIDEiQ75AB5

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS51923

Structurei

3D structure databases

ProteinModelPortaliQ75AB5
SMRiQ75AB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000241277
InParanoidiQ75AB5
KOiK01809
OMAiMGTHPSN
OrthoDBiEOG092C3NWF

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q75AB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKLFRLDA GYQQYDWGKI GSSSAVAQYA ANSDPSVQIE EDKPYAELWM
60 70 80 90 100
GTHHKVPSRH HDTKVALSDL IAANPEGMLG SGNVEKFHSR KDLPFLFKVL
110 120 130 140 150
SIEKVLSIQA HPDKNLGRRL HIQDPKNYPD DNHKPEMAIA ISDFEGFCGF
160 170 180 190 200
KPLEELAEEL QRIPEFRSLV GEDIAAQFCA GIKVGAQEGS EEDKSNRKLL
210 220 230 240 250
QSVFSNVMNA SDDVIASHAR HLVERAKQSP ADFNNETLPA LILRLNEQFP
260 270 280 290 300
EDVGLFCGCL MLNHCVLKAG ESIFLRAKDP HAYITGDIIE CMAASDNVVR
310 320 330 340 350
AGFTPKFKDV KNLVEMLTYS YDSVEDQKMK LLPFARSSGS GDSILYNPPI
360 370 380 390 400
EEFAVLQTNF HGSTGTHHFD GLDGPSIVIT TNGSGYIQSG DVRLKAEAGY
410 420
VFFIAPHAEV DLQTEDSNFT TYRAFVEPN
Length:429
Mass (Da):47,530
Last modified:July 5, 2004 - v1
Checksum:i7755EF1BC22F072A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA Translation: AAS51923.1
RefSeqiNP_984099.1, NM_209452.1

Genome annotation databases

EnsemblFungiiAAS51923; AAS51923; AGOS_ADR003C
GeneIDi4620247
KEGGiago:AGOS_ADR003C

Similar proteinsi

Entry informationi

Entry nameiMPI_ASHGO
AccessioniPrimary (citable) accession number: Q75AB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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