Q75A74 (CWC27_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl isomerase CWC27
Short name=PPIase CWC27
EC=5.2.1.8

Alternative name(s):
Rotamase CWC27

Gene names

Name:	CWC27
Ordered Locus Names:	ADR044C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Peptidyl-prolyl isomerase CWC27		PRO_0000064180
Regions
	Domain	7 – 153	147	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q75A74 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2E69CE291FE0C98A	FASTA	303	32,485
	10 20 30 40 50 60 MSSEPSASGK CVLYTTKGEL QIELWAKECP KTVRSFLQSI QDGKWDGIVL GKVAEDAVWA 70 80 90 100 110 120 PAGLCACSAE INGRLRFNRR GLVGMAPGQD QPFFTLASRG ELDGRAVVFG TLVGQSVYRL 130 140 150 160 170 180 MEIAQGEVGD DGKTFVYPAE VRRAEVTIPY FDGLSGQKRR AEPEQQAAPR PRKIATRVRL 190 200 210 220 230 240 EYEESEDEAS DPPLDVRIRA AHDILQDERL TDALHGDSPP PRPAEAPRGS DSAPCVASPD 250 260 270 280 290 300 RRAEAAPPTD GPPSRCASLA GPAPASPGPV TDLAPQLSAR EQGTLSSLAE FRCKRGGKNP LLG

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016817 Genomic DNA. Translation: AAS51964.1.
RefSeq	NP_984140.1. NM_209493.1.
3D structure databases
ProteinModelPortal	Q75A74.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4620289.
GenomeReviews	Gene locus ADR044C in contig AE016817_GR.
KEGG	ago:AGOS_ADR044C.
NMPDR	fig|33169.1.peg.1785.
Organism-specific databases
AGD	ADR044C.
Phylogenomic databases
eggNOG	fuNOG06026.
OMA	IELWAKE.
OrthoDB	EOG4XD70H.
PhylomeDB	Q75A74.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K01802.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. False negative. PS50072. CSA_PPIASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_ASHGO

Accession

Primary (citable) accession number: Q75A74

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program