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Protein

Protein arginine N-methyltransferase 2

Gene

RMT2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei199S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei229S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei321S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:RMT2By similarity
Ordered Locus Names:ADR161W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289691 – 413Protein arginine N-methyltransferase 2Add BLAST413

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ759W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 413RMT2PROSITE-ProRule annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 257S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni273 – 275S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni300 – 301S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation
Contains 1 RMT2 (arginine N-methyltransferase 2-like) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ759W1.
KOiK18477.
OMAiFEYGAGW.
OrthoDBiEOG092C2OT7.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR017408. Arginine_N-MeTrfase_2.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF038148. Arginine_N-mtfrase-2. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51559. SAM_RMT2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q759W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLHHLVTL PSRPITRDAY LPQLQNLLRS GIPATYTLEQ LAAYEKGDEE
60 70 80 90 100
GPGDEDTNTT PLHIMARSLP EAGQLSEAES EVVLEIMDTL FQYGAGWNFL
110 120 130 140 150
DYEQKHAGDL LLEKGYGPGD ALYERLVEAG VAAELLLRKV NGGEIEFLDG
160 170 180 190 200
SDTEMGDKGG SARDVPASAD SAPADSAGHS SSEPTAVDAD ATAAHQDTYL
210 220 230 240 250
QTELEYIPGA LVTKHNRDGV MMDWETDIMR VAAASIVKNR EPAECQVLNI
260 270 280 290 300
GFGMGIIDGF LQEQRPTRHY ICEAHPDVLA RMRREGWYER PDVVILEGRW
310 320 330 340 350
QDTLSRLLDD GTVFFDGIYY DTFSEHYTDM LELYDLVVGL IKPCGIFSFF
360 370 380 390 400
NGLGADRQVC YDVYRRIVEL DMATYGMTCE YTTIDLRQLP TWDNVRRSYF
410
NCDHYYHPEI SFQ
Length:413
Mass (Da):46,357
Last modified:July 5, 2004 - v1
Checksum:i920B5F090A722B78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52082.1.
RefSeqiNP_984258.1. NM_209611.1.

Genome annotation databases

EnsemblFungiiAAS52082; AAS52082; AGOS_ADR161W.
GeneIDi4620420.
KEGGiago:AGOS_ADR161W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52082.1.
RefSeqiNP_984258.1. NM_209611.1.

3D structure databases

ProteinModelPortaliQ759W1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52082; AAS52082; AGOS_ADR161W.
GeneIDi4620420.
KEGGiago:AGOS_ADR161W.

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ759W1.
KOiK18477.
OMAiFEYGAGW.
OrthoDBiEOG092C2OT7.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR017408. Arginine_N-MeTrfase_2.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF038148. Arginine_N-mtfrase-2. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51559. SAM_RMT2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRMT2_ASHGO
AccessioniPrimary (citable) accession number: Q759W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.