Reviewed, UniProtKB/Swiss-Prot Q759S7 (ERG6_ASHGO)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
Ordered Locus Names:	ADR196W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Sterol 24-C-methyltransferase		PRO_0000124788

Sequences

	Sequence		Length	Mass (Da)
	Q759S7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A2672523ACF99962	FASTA	373	41,746
	10 20 30 40 50 60 MSEQDQELRN RQAQFAKELH GESVERSGLT ALLGKNREAQ QEAVAKYLRH WDGATDAEAE 70 80 90 100 110 120 ERRLADYNES THSYYNVVTD FYEYGWGASF HFSRFYTGES FAMSMARHEH YLAHRAGITS 130 140 150 160 170 180 GDLVLDVGCG VGGPAREIAR FTGCRVVGLN NNDYQIMKGK HYSRKLGLGD QVSYVKGDFM 190 200 210 220 230 240 NMDFPDATFD KVYAIEATCH APSFEGVYGE IYRVLKPGGV FAVYEWVMTE NYDETNPEHR 250 260 270 280 290 300 RIAYDIELGD GIPKMYSVKV ARDALAKVGF EILVDEDRAD NDDPVPWYYP LTGEWAYIQT 310 320 330 340 350 360 IADLGTFVRT SALGRRVTSA FVSLMETLRL APRGSSEVVN ALESAAAGLV AGGKSKLFTP 370 MMLFVARKPE TAE

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016817 Genomic DNA. Translation: AAS52116.1.
RefSeq	NP_984292.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4620454.
KEGG	ago:AGOS_ADR196W.
NMPDR	fig|33169.1.peg.1937.
Organism-specific databases
AGD	ADR196W.
Phylogenomic databases
HOGENOM	Q759S7.
OMA	Q759S7. FVKGDFM.
Enzyme and pathway databases
BRENDA	2.1.1.41. 279361.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_ASHGO

Accession

Primary (citable) accession number: Q759S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	May 5, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)