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Q759S7

- ERG6_ASHGO

UniProt

Q759S7 - ERG6_ASHGO

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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:ADR196W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome IV

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: EnsemblFungi
  2. mitochondrial outer membrane Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Sterol 24-C-methyltransferasePRO_0000124788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ADR196W.

Structurei

3D structure databases

ProteinModelPortaliQ759S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000171097.
InParanoidiQ759S7.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q759S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQDQELRN RQAQFAKELH GESVERSGLT ALLGKNREAQ QEAVAKYLRH
60 70 80 90 100
WDGATDAEAE ERRLADYNES THSYYNVVTD FYEYGWGASF HFSRFYTGES
110 120 130 140 150
FAMSMARHEH YLAHRAGITS GDLVLDVGCG VGGPAREIAR FTGCRVVGLN
160 170 180 190 200
NNDYQIMKGK HYSRKLGLGD QVSYVKGDFM NMDFPDATFD KVYAIEATCH
210 220 230 240 250
APSFEGVYGE IYRVLKPGGV FAVYEWVMTE NYDETNPEHR RIAYDIELGD
260 270 280 290 300
GIPKMYSVKV ARDALAKVGF EILVDEDRAD NDDPVPWYYP LTGEWAYIQT
310 320 330 340 350
IADLGTFVRT SALGRRVTSA FVSLMETLRL APRGSSEVVN ALESAAAGLV
360 370
AGGKSKLFTP MMLFVARKPE TAE
Length:373
Mass (Da):41,746
Last modified:July 5, 2004 - v1
Checksum:iA2672523ACF99962
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS52116.1.
RefSeqiNP_984292.1. NM_209645.1.

Genome annotation databases

EnsemblFungiiAAS52116; AAS52116; AGOS_ADR196W.
GeneIDi4620454.
KEGGiago:AGOS_ADR196W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS52116.1 .
RefSeqi NP_984292.1. NM_209645.1.

3D structure databases

ProteinModelPortali Q759S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ADR196W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS52116 ; AAS52116 ; AGOS_ADR196W .
GeneIDi 4620454.
KEGGi ago:AGOS_ADR196W.

Phylogenomic databases

eggNOGi COG0500.
HOGENOMi HOG000171097.
InParanoidi Q759S7.
KOi K00559.
OMAi FHFCRFS.
OrthoDBi EOG7DVDMW.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiERG6_ASHGO
AccessioniPrimary (citable) accession number: Q759S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3