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Protein

Calpain-like protease palB/RIM13

Gene

RIM13

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351By similarity
Active sitei276 – 2761By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB/RIM13 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease RIM13
Gene namesi
Name:RIM13
Ordered Locus Names:ADR274C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Calpain-like protease palB/RIM13PRO_0000207736Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 320241Calpain catalyticAdd
BLAST

Sequence similaritiesi

Contains 1 calpain catalytic domain.Curated

Phylogenomic databases

InParanoidiQ759K3.
OrthoDBiEOG74R21M.

Sequencei

Sequence statusi: Complete.

Q759K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALLAVEET GNDLWKELKE LYWAQYVQNS VDKVQFERYV RKVKSADDYW
60 70 80 90 100
LVRALLAFSD SRKACTFNSR FEWLTMQAHG RQYPPLASKD AGKLIWNARR
110 120 130 140 150
EFRYAEPQQA AYKQLARPRG DAVADIQQHP DLGNCSMVCA LINVKRTCGT
160 170 180 190 200
ADMVADCGDV AQVNLFFNGA RRLVTLHRAE VRQNMRREQL AVLSPDMHDK
210 220 230 240 250
LIEQAYFEVA HGMNYESMGS NTAMDTYMLC GWFPLVVETS EVDFPFVQRY
260 270 280 290 300
LARGAMLALG THATRTIDSF CLRKNHDYAV LDVCGTVFRI RDPLVAGNVI
310 320 330 340 350
ELAWEDVRTA FHLLYINWDA HTQCQLYEKF HFRYNSAVHN RFMSWLNKPT
360 370 380 390 400
YRVVNDTESE LPVYALFERH LSNRKYDNSI VGVISGENLV SDTEEGNNIG
410 420 430 440 450
MQWVELTVPP HSSRILFYHS NTNTNCTLHL FSNSPRLKVA KWSSAESSRL
460 470 480 490 500
AVLDGCWQPI SKNLTFTHWP AFKFEIKHPE TDGVHVSLQF CWANEHSAAL
510 520 530 540 550
FIYHASDYRY EKPLLHRPGP LPFPQAFFEL ALDTNTPYVV LCQSMDVGAD
560 570 580 590 600
AAFQLAIQTE KQGSVISTVP TSRAYGGLRF HTSKLVSTAA KRIELPFKVS
610 620 630 640 650
RSTDLHITLY SKSSPLVLKC AVFSDGSDEA ITATPGFVPI NDYPYVLPIT
660 670 680 690
FAKERSLVLL IELQDTVPDS TVTIEIGSNC AFNFCGHDVD LARV
Length:694
Mass (Da):78,836
Last modified:January 9, 2013 - v2
Checksum:i1B5D62C479951178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52194.2.
RefSeqiNP_984370.2. NM_209723.2.

Genome annotation databases

EnsemblFungiiAAS52194; AAS52194; AGOS_ADR274C.
GeneIDi4620532.
KEGGiago:AGOS_ADR274C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52194.2.
RefSeqiNP_984370.2. NM_209723.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52194; AAS52194; AGOS_ADR274C.
GeneIDi4620532.
KEGGiago:AGOS_ADR274C.

Phylogenomic databases

InParanoidiQ759K3.
OrthoDBiEOG74R21M.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 235-236; 238; 269 AND 273.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiPALB_ASHGO
AccessioniPrimary (citable) accession number: Q759K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 9, 2013
Last modified: May 11, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Asn residue of the catalytic triad in position 292, which is replaced by an Asp residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.