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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPD

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167NADBy similarity1
Binding sitei190NAD; via amide nitrogenBy similarity1
Binding sitei190SubstrateBy similarity1
Binding sitei223NAD; via amide nitrogenBy similarity1
Active sitei283Proton acceptorBy similarity1
Binding sitei348NADBy similarity1
Binding sitei377NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 84NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
Ordered Locus Names:ADR311C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380851 – 424Glycerol-3-phosphate dehydrogenase [NAD(+)]Add BLAST424

Structurei

3D structure databases

ProteinModelPortaliQ759G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 349Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ759G5.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG092C3ZQP.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q759G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNTTALIRS PTFVAQFRVL KQVNRGLFSQ TSYARTHART SYTHTMAGTD
60 70 80 90 100
RLQQTSQILS RSTSSEIRLE RPFKVTVIGS GNWGTTIAKV VAENTQEYPQ
110 120 130 140 150
LFERRVDMWV FEEQIEGRKL TEIINEQHEN VKYLPGITLP ENLVANPSVA
160 170 180 190 200
AAAADADVLV FNIPHQFLGR IVEQLKGHVK PGARAISCLK GFSVGKDGVQ
210 220 230 240 250
LLSTYIEEHL HIPCGALSGA NLAPEVAKGN WSETTVAYTL PQDFRGTGKD
260 270 280 290 300
VDHAVLKKLF HRPYFHVNVV DDVAGISVAG ALKNVVALAC GFVLGLGWGN
310 320 330 340 350
NAAAAVQRVG LSEMIKFARM FFPESKVETF YQESAGVADL ITTCAGGRNV
360 370 380 390 400
RIGRAMAETG KSAQELEKEL LNGQSSQGIY TTQEVHEWLQ QCGKKDEFPL
410 420
FEAVYKIVYE GVPMSKLPDM LEDA
Length:424
Mass (Da):46,646
Last modified:July 5, 2004 - v1
Checksum:i014C3D1A7F251630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52231.1.
RefSeqiNP_984407.1. NM_209760.1.

Genome annotation databases

EnsemblFungiiAAS52231; AAS52231; AGOS_ADR311C.
GeneIDi4620680.
KEGGiago:AGOS_ADR311C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS52231.1.
RefSeqiNP_984407.1. NM_209760.1.

3D structure databases

ProteinModelPortaliQ759G5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52231; AAS52231; AGOS_ADR311C.
GeneIDi4620680.
KEGGiago:AGOS_ADR311C.

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ759G5.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG092C3ZQP.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPD_ASHGO
AccessioniPrimary (citable) accession number: Q759G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.