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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPD

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167NADBy similarity1
Binding sitei190NAD; via amide nitrogenBy similarity1
Binding sitei190SubstrateBy similarity1
Binding sitei223NAD; via amide nitrogenBy similarity1
Active sitei283Proton acceptorBy similarity1
Binding sitei348NADBy similarity1
Binding sitei377NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 84NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
Ordered Locus Names:ADR311C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome IV

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380851 – 424Glycerol-3-phosphate dehydrogenase [NAD(+)]Add BLAST424

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi33169.AAS52231

Structurei

3D structure databases

ProteinModelPortaliQ759G5
SMRiQ759G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 349Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855
InParanoidiQ759G5
KOiK00006
OMAiWLCKGFE
OrthoDBiEOG092C3ZQP

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q759G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNTTALIRS PTFVAQFRVL KQVNRGLFSQ TSYARTHART SYTHTMAGTD
60 70 80 90 100
RLQQTSQILS RSTSSEIRLE RPFKVTVIGS GNWGTTIAKV VAENTQEYPQ
110 120 130 140 150
LFERRVDMWV FEEQIEGRKL TEIINEQHEN VKYLPGITLP ENLVANPSVA
160 170 180 190 200
AAAADADVLV FNIPHQFLGR IVEQLKGHVK PGARAISCLK GFSVGKDGVQ
210 220 230 240 250
LLSTYIEEHL HIPCGALSGA NLAPEVAKGN WSETTVAYTL PQDFRGTGKD
260 270 280 290 300
VDHAVLKKLF HRPYFHVNVV DDVAGISVAG ALKNVVALAC GFVLGLGWGN
310 320 330 340 350
NAAAAVQRVG LSEMIKFARM FFPESKVETF YQESAGVADL ITTCAGGRNV
360 370 380 390 400
RIGRAMAETG KSAQELEKEL LNGQSSQGIY TTQEVHEWLQ QCGKKDEFPL
410 420
FEAVYKIVYE GVPMSKLPDM LEDA
Length:424
Mass (Da):46,646
Last modified:July 5, 2004 - v1
Checksum:i014C3D1A7F251630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA Translation: AAS52231.1
RefSeqiNP_984407.1, NM_209760.1

Genome annotation databases

EnsemblFungiiAAS52231; AAS52231; AGOS_ADR311C
GeneIDi4620680
KEGGiago:AGOS_ADR311C

Similar proteinsi

Entry informationi

Entry nameiGPD_ASHGO
AccessioniPrimary (citable) accession number: Q759G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health