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Q759G5 (GPD_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]
EC=1.1.1.8
Gene names
Name:GPD
Ordered Locus Names:ADR311C
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium ›

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Glycerol-3-phosphate dehydrogenase [NAD(+)]
PRO_0000138085

Regions

Nucleotide binding79 – 846NAD By similarity
Region348 – 3492Substrate binding By similarity

Sites

Active site2831Proton acceptor By similarity
Binding site1671NAD By similarity
Binding site1901NAD; via amide nitrogen By similarity
Binding site1901Substrate By similarity
Binding site2231NAD; via amide nitrogen By similarity
Binding site3481NAD By similarity
Binding site3771NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q759G5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 014C3D1A7F251630

FASTA42446,646
        10         20         30         40         50         60 
MVNTTALIRS PTFVAQFRVL KQVNRGLFSQ TSYARTHART SYTHTMAGTD RLQQTSQILS 

        70         80         90        100        110        120 
RSTSSEIRLE RPFKVTVIGS GNWGTTIAKV VAENTQEYPQ LFERRVDMWV FEEQIEGRKL 

       130        140        150        160        170        180 
TEIINEQHEN VKYLPGITLP ENLVANPSVA AAAADADVLV FNIPHQFLGR IVEQLKGHVK 

       190        200        210        220        230        240 
PGARAISCLK GFSVGKDGVQ LLSTYIEEHL HIPCGALSGA NLAPEVAKGN WSETTVAYTL 

       250        260        270        280        290        300 
PQDFRGTGKD VDHAVLKKLF HRPYFHVNVV DDVAGISVAG ALKNVVALAC GFVLGLGWGN 

       310        320        330        340        350        360 
NAAAAVQRVG LSEMIKFARM FFPESKVETF YQESAGVADL ITTCAGGRNV RIGRAMAETG 

       370        380        390        400        410        420 
KSAQELEKEL LNGQSSQGIY TTQEVHEWLQ QCGKKDEFPL FEAVYKIVYE GVPMSKLPDM 


LEDA

« Hide

References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016817 Genomic DNA. Translation: AAS52231.1.
RefSeqNP_984407.1. NM_209760.1.

3D structure databases

ProteinModelPortalQ759G5.
SMRQ759G5. Positions 73-422.
ModBaseSearch...

Protein-protein interaction databases

STRING33169.AGOS_ADR311C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS52231; AAS52231; AGOS_ADR311C.
GeneID4620680.
KEGGago:AGOS_ADR311C.

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246855.
KOK00006.
OMAFHVNVIE.
OrthoDBEOG4FBN2Q.
PhylomeDBQ759G5.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPD_ASHGO
AccessionPrimary (citable) accession number: Q759G5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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