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Q759A9 (KPYK_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:PYK1
Ordered Locus Names:ADR368W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Pyruvate kinase
PRO_0000112107

Sites

Metal binding521Potassium By similarity
Metal binding541Potassium By similarity
Metal binding851Potassium By similarity
Metal binding861Potassium; via carbonyl oxygen By similarity
Metal binding2431Magnesium Potential
Metal binding2671Magnesium By similarity
Binding site501Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2671Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site3381ADP Potential
Site2411Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q759A9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C474BC449337CDD1

FASTA50154,808
        10         20         30         40         50         60 
MESRLGWLTR LNYDTGSALR RTSIIGTIGP KTNNPETLVE LRKAGLNIVR MNFSHGSYEY 

        70         80         90        100        110        120 
HQSVIDNARK SEELYPGRPL AIALDTKGPE IRTGTTVDNV DYPIPPNHEM IFTTDDQYAK 

       130        140        150        160        170        180 
SCDDKVMFVD YKNITKVIEK GRVIYVDDGV LSFEVLEVVD DKTLKVKSLN AGKICSHKGV 

       190        200        210        220        230        240 
NLPGTDVDLP ALSEKDKSDL RFGVKNGVHM VFASFIRTAG DILTIREILG EDGKDIKIIA 

       250        260        270        280        290        300 
KIENQQGVNN FDEILKVTDG VMVARGDLGI EIPAPQVFAV QKMLIAKCNL AGKPVICATQ 

       310        320        330        340        350        360 
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGI YPINAVKTMA ETALIAEQAI 

       370        380        390        400        410        420 
PYVPTYDDLR NLTPKPTPTS ETIAAAAVAA TFEQKAKAIV VLSTSGDTTR LVSKYKPNVP 

       430        440        450        460        470        480 
IVMVTRNPRA ARYCHLHRGV FPFVYEQEAA DEWTDDVEAR LNFGVEKSKE LGILSEGDTI 

       490        500 
VTIQGFASGV GHSNTLRVLT V 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016817 Genomic DNA. Translation: AAS52288.1.
RefSeqNP_984464.1. NM_209817.1.

3D structure databases

ProteinModelPortalQ759A9.
SMRQ759A9. Positions 3-501.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_ADR368W.

Proteomic databases

PRIDEQ759A9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS52288; AAS52288; AGOS_ADR368W.
GeneID4620629.
KEGGago:AGOS_ADR368W.

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021559.
KOK00873.
OMANNKGVNF.
OrthoDBEOG7M6DJC.
PhylomeDBQ759A9.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_ASHGO
AccessionPrimary (citable) accession number: Q759A9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: December 11, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways