Q758X0 (ACS1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 1
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 1
Acyl-activating enzyme 1

Gene names

Name:	ACS1
Ordered Locus Names:	ADR408W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	694 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Subcellular location	Microsome Potential. Endoplasmic reticulum Potential.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 694	694	Acetyl-coenzyme A synthetase 1		PRO_0000208403
Regions
	Motif	692 – 694	3	Microbody targeting signal Potential

Sequences

	Sequence		Length	Mass (Da)
	Q758X0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 901542DF3FD3A31F	FASTA	694	76,809
	10 20 30 40 50 60 MVTSAGVGHA EYNNGADVQH ADYAHLTSVG QVEQKPLGGR LGALAEYYKP NVASMEEYRA 70 80 90 100 110 120 MHAQSITDPA AFYGERARTY VDWFRPFDAV FLPGPDGRPS FDNNAWFVNG QLNACYNLVD 130 140 150 160 170 180 RHAARTPDKV AIIYEADEPG EGYSLTYREL LAQVCKVAQV LQYSMGVRKG DTVAVYMPMI 190 200 210 220 230 240 PQALVTLLAI SRIGAIHSVV FAGFSSNSLR DRINDARSEV VVTTDESKRG GKIIETKRIV 250 260 270 280 290 300 DDAIKETPQL RKVLVYKRTC NPSVSYVADR DLDWDTEVKK YKSYCPCEPV DSEHPLFLLY 310 320 330 340 350 360 TSGSTGAPKG VQHSTAGYLL QAYLSMLYSF DVHSDDIFFT AGDIGWITGH TYVVYGPLFS 370 380 390 400 410 420 GCTTVVFEGT PAYPSYSRYW DIIDKYSVTQ FYVAPTALRL LKRAGDSYVD GYSLRTLRSL 430 440 450 460 470 480 GTVGEPIAAE VWEWYYTVIG KREIPVIDTY WQTESGAHLV TPLAGGSTPM KPGSASFPFF 490 500 510 520 530 540 GIDLAILDPQ TGEELLGPNV EGVLAVKQPW PSFTRTIWNN HDRYLDTYLN PYKGYYFAGD 550 560 570 580 590 600 GAARDSQGFI WILGRVDDVV NVSGHRLSTA EVEAAIIQES MVAECAVVGF ADELTGQAIA 610 620 630 640 650 660 AFVVLKQKSS WNTASERELQ EIKKHLILSV RRDIGPFAAP KLIVLVDDLP KTRSGKIMRR 670 680 690 ILRKILAGEA DQLGDVSTLS NPGIVKHLIE SVKF

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016817 Genomic DNA. Translation: AAS52327.1.
RefSeq	NP_984503.1. NM_209856.1.
3D structure databases
ProteinModelPortal	Q758X0.
SMR	Q758X0. Positions 56-694.
ModBase	Search...
Protein-protein interaction databases
STRING	Q758X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4620668.
GenomeReviews	Gene locus ADR408W in contig AE016817_GR.
KEGG	ago:AGOS_ADR408W.
NMPDR	fig|33169.1.peg.2148.
Organism-specific databases
AGD	ADR408W.
Phylogenomic databases
eggNOG	fuNOG05220.
HOGENOM	HBG547964.
OMA	HQRMVDT.
OrthoDB	EOG4M0J8W.
PhylomeDB	Q758X0.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS1_ASHGO

Accession

Primary (citable) accession number: Q758X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program