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Q758U2

- SIL1_ASHGO

UniProt

Q758U2 - SIL1_ASHGO

Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.By similarity

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleotide exchange factor SIL1
    Gene namesi
    Name:SIL1
    Ordered Locus Names:AEL340W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome V

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 383366Nucleotide exchange factor SIL1PRO_0000223359Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with KAR2.By similarity

    Protein-protein interaction databases

    STRINGi33169.AGOS_AEL340W.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi380 – 3834Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the SIL1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG244873.
    HOGENOMiHOG000154325.
    KOiK14001.
    OMAiCAPRITA.
    OrthoDBiEOG7V1G2Q.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q758U2-1 [UniParc]FASTAAdd to Basket

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    MYWKKLLFAI ASAAALAAVD PETEGSELQT ICSGGECYPR LFKALQDWST    50
    IKEGQQIPPG LDIRVDLSTG KKQARLPIPN EASNMENGIQ VVDDSSDYEF 100
    TKEFQLVRAQ VASGAPDYNV VIKQLDDLVE YASDYTLGYK IITHEFTLLQ 150
    ELIFGQDVPI SVKELSSRII VACLRNNTPC LDFVNTRFPD FVRHLLQEAV 200
    DYGRQATDAV EARTQIKRYL SIVEPLLINE PQPINEEALK QLYEVNDQTV 250
    QLKVLLIMAR LYKGRSHNDD ISKRSLESTD VQRWTTELSK AIQSKHLDDF 300
    HVRELFHGLY ALKKEHGRAV KTYPTFLGWL AEETEARKQR MTQDKQPRDL 350
    EQMEFDRLLI ESRHMVFGNP MAHRIKNMEY DEL 383
    Length:383
    Mass (Da):43,998
    Last modified:July 5, 2004 - v1
    Checksum:iBDC81E26AEB71D67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52344.1.
    RefSeqiNP_984520.1. NM_209873.1.

    Genome annotation databases

    EnsemblFungiiAAS52344; AAS52344; AGOS_AEL340W.
    GeneIDi4620690.
    KEGGiago:AGOS_AEL340W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52344.1 .
    RefSeqi NP_984520.1. NM_209873.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AEL340W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS52344 ; AAS52344 ; AGOS_AEL340W .
    GeneIDi 4620690.
    KEGGi ago:AGOS_AEL340W.

    Phylogenomic databases

    eggNOGi NOG244873.
    HOGENOMi HOG000154325.
    KOi K14001.
    OMAi CAPRITA.
    OrthoDBi EOG7V1G2Q.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiSIL1_ASHGO
    AccessioniPrimary (citable) accession number: Q758U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3