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Q758U2 (SIL1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleotide exchange factor SIL1
Gene names
Name:SIL1
Ordered Locus Names:AEL340W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium ›

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.

Subunit structure

Interacts with KAR2 By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the SIL1 family.

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 383366Nucleotide exchange factor SIL1
PRO_0000223359

Regions

Motif380 – 3834Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q758U2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BDC81E26AEB71D67

FASTA38343,998
        10         20         30         40         50         60 
MYWKKLLFAI ASAAALAAVD PETEGSELQT ICSGGECYPR LFKALQDWST IKEGQQIPPG 

        70         80         90        100        110        120 
LDIRVDLSTG KKQARLPIPN EASNMENGIQ VVDDSSDYEF TKEFQLVRAQ VASGAPDYNV 

       130        140        150        160        170        180 
VIKQLDDLVE YASDYTLGYK IITHEFTLLQ ELIFGQDVPI SVKELSSRII VACLRNNTPC 

       190        200        210        220        230        240 
LDFVNTRFPD FVRHLLQEAV DYGRQATDAV EARTQIKRYL SIVEPLLINE PQPINEEALK 

       250        260        270        280        290        300 
QLYEVNDQTV QLKVLLIMAR LYKGRSHNDD ISKRSLESTD VQRWTTELSK AIQSKHLDDF 

       310        320        330        340        350        360 
HVRELFHGLY ALKKEHGRAV KTYPTFLGWL AEETEARKQR MTQDKQPRDL EQMEFDRLLI 

       370        380 
ESRHMVFGNP MAHRIKNMEY DEL

« Hide

References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016818 Genomic DNA. Translation: AAS52344.1.
RefSeqNP_984520.1. NM_209873.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING33169.AGOS_AEL340W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS52344; AAS52344; AGOS_AEL340W.
GeneID4620690.
KEGGago:AGOS_AEL340W.

Phylogenomic databases

eggNOGNOG244873.
HOGENOMHOG000154325.
KOK14001.
OMAVFGNPMA.
OrthoDBEOG40312K.
PhylomeDBQ758U2.

Family and domain databases

PROSITEPS00014. ER_TARGET. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIL1_ASHGO
AccessionPrimary (citable) accession number: Q758U2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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