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Q758U2

- SIL1_ASHGO

UniProt

Q758U2 - SIL1_ASHGO

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Protein

Nucleotide exchange factor SIL1

Gene
SIL1, AEL340W
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
Ordered Locus Names:AEL340W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome V

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 383366Nucleotide exchange factor SIL1PRO_0000223359Add
BLAST

Interactioni

Subunit structurei

Interacts with KAR2 By similarity.

Protein-protein interaction databases

STRINGi33169.AGOS_AEL340W.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi380 – 3834Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the SIL1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG244873.
HOGENOMiHOG000154325.
KOiK14001.
OMAiCAPRITA.
OrthoDBiEOG7V1G2Q.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q758U2-1 [UniParc]FASTAAdd to Basket

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MYWKKLLFAI ASAAALAAVD PETEGSELQT ICSGGECYPR LFKALQDWST    50
IKEGQQIPPG LDIRVDLSTG KKQARLPIPN EASNMENGIQ VVDDSSDYEF 100
TKEFQLVRAQ VASGAPDYNV VIKQLDDLVE YASDYTLGYK IITHEFTLLQ 150
ELIFGQDVPI SVKELSSRII VACLRNNTPC LDFVNTRFPD FVRHLLQEAV 200
DYGRQATDAV EARTQIKRYL SIVEPLLINE PQPINEEALK QLYEVNDQTV 250
QLKVLLIMAR LYKGRSHNDD ISKRSLESTD VQRWTTELSK AIQSKHLDDF 300
HVRELFHGLY ALKKEHGRAV KTYPTFLGWL AEETEARKQR MTQDKQPRDL 350
EQMEFDRLLI ESRHMVFGNP MAHRIKNMEY DEL 383
Length:383
Mass (Da):43,998
Last modified:July 5, 2004 - v1
Checksum:iBDC81E26AEB71D67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016818 Genomic DNA. Translation: AAS52344.1.
RefSeqiNP_984520.1. NM_209873.1.

Genome annotation databases

EnsemblFungiiAAS52344; AAS52344; AGOS_AEL340W.
GeneIDi4620690.
KEGGiago:AGOS_AEL340W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016818 Genomic DNA. Translation: AAS52344.1 .
RefSeqi NP_984520.1. NM_209873.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AEL340W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS52344 ; AAS52344 ; AGOS_AEL340W .
GeneIDi 4620690.
KEGGi ago:AGOS_AEL340W.

Phylogenomic databases

eggNOGi NOG244873.
HOGENOMi HOG000154325.
KOi K14001.
OMAi CAPRITA.
OrthoDBi EOG7V1G2Q.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiSIL1_ASHGO
AccessioniPrimary (citable) accession number: Q758U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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