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Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
Ordered Locus Names:AEL340W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591 Componenti: Chromosome V

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 383366Nucleotide exchange factor SIL1PRO_0000223359Add
BLAST

Interactioni

Subunit structurei

Interacts with KAR2.By similarity

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi380 – 3834Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG244873.
HOGENOMiHOG000154325.
InParanoidiQ758U2.
KOiK14001.
OMAiVFGNPMA.
OrthoDBiEOG7V1G2Q.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q758U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYWKKLLFAI ASAAALAAVD PETEGSELQT ICSGGECYPR LFKALQDWST
60 70 80 90 100
IKEGQQIPPG LDIRVDLSTG KKQARLPIPN EASNMENGIQ VVDDSSDYEF
110 120 130 140 150
TKEFQLVRAQ VASGAPDYNV VIKQLDDLVE YASDYTLGYK IITHEFTLLQ
160 170 180 190 200
ELIFGQDVPI SVKELSSRII VACLRNNTPC LDFVNTRFPD FVRHLLQEAV
210 220 230 240 250
DYGRQATDAV EARTQIKRYL SIVEPLLINE PQPINEEALK QLYEVNDQTV
260 270 280 290 300
QLKVLLIMAR LYKGRSHNDD ISKRSLESTD VQRWTTELSK AIQSKHLDDF
310 320 330 340 350
HVRELFHGLY ALKKEHGRAV KTYPTFLGWL AEETEARKQR MTQDKQPRDL
360 370 380
EQMEFDRLLI ESRHMVFGNP MAHRIKNMEY DEL
Length:383
Mass (Da):43,998
Last modified:July 5, 2004 - v1
Checksum:iBDC81E26AEB71D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52344.1.
RefSeqiNP_984520.1. NM_209873.1.

Genome annotation databases

EnsemblFungiiAAS52344; AAS52344; AGOS_AEL340W.
GeneIDi4620690.
KEGGiago:AGOS_AEL340W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52344.1.
RefSeqiNP_984520.1. NM_209873.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52344; AAS52344; AGOS_AEL340W.
GeneIDi4620690.
KEGGiago:AGOS_AEL340W.

Phylogenomic databases

eggNOGiNOG244873.
HOGENOMiHOG000154325.
InParanoidiQ758U2.
KOiK14001.
OMAiVFGNPMA.
OrthoDBiEOG7V1G2Q.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiSIL1_ASHGO
AccessioniPrimary (citable) accession number: Q758U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.