Q758L0 (G6PI_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	PGI1
Ordered Locus Names:	AEL249C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Glucose-6-phosphate isomerase		PRO_0000180570
Sites
	Active site	368	1	Proton donor By similarity
	Active site	399	1	By similarity
	Active site	521	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q758L0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BE12632073654FDD	FASTA	555	61,257
	10 20 30 40 50 60 MATTNTFSDF KLASELPAWA KLQELYEKKG KTLSLKEAFA TDEQRFQKYS RTFSNHDGSK 70 80 90 100 110 120 ILFDFSKNLV DDEILGALAQ LAREANVTQL RDQMFNGEHI NSTEDRAVYH VALRNRANKP 130 140 150 160 170 180 MYVDGKNVAP EVDAVLQHMK EFSEQVRSGA WKGYTGKSIK DVVNIGIGGS DLGPVMVTEA 190 200 210 220 230 240 LKHYAGPLKV HFVSNIDGTH LAETLKEVDP ETTLFLVASK TFTTAETITN ATSAKNWFLS 250 260 270 280 290 300 KTGNNPAHIS KHFAALSTNE TEVAKFGIDT KNMFGFESWV GGRYSVWSAI GLSVALYIGF 310 320 330 340 350 360 DQFEDFLKGA EAVDKHFTST PIEDNIPLLG GLLSVWYNNF FDAQTHLVVP FDQYLHRFPA 370 380 390 400 410 420 YLQQLSMESN GKSVTRGNVF ANYSTGSILF GEPATNAQHS FFQLVHQGTK VIPSDFILAA 430 440 450 460 470 480 QSHNPIENNL HQKMLASNFF AQAEALMVGK DEAQVKAEGA TGGLVPHKVF SGNRPTTSIL 490 500 510 520 530 540 VQKITPANLG ALIAYYEHVT FTEGAIWNIN SFDQWGVELG KVLAKVIGKD LDTTGETTSH 550 DASTNGLINQ FKAWL

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS52436.1.
RefSeq	NP_984612.1. NM_209965.1.
3D structure databases
ProteinModelPortal	Q758L0.
SMR	Q758L0. Positions 14-554.
ModBase	Search...
Protein-protein interaction databases
STRING	Q758L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4620794.
GenomeReviews	Gene locus AEL249C in contig AE016818_GR.
KEGG	ago:AGOS_AEL249C.
NMPDR	fig|33169.1.peg.2257.
Organism-specific databases
AGD	AEL249C.
Phylogenomic databases
eggNOG	fuNOG04321.
HOGENOM	HBG352954.
OMA	NSLPAWT.
OrthoDB	EOG43NBN0.
PhylomeDB	Q758L0.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ASHGO

Accession

Primary (citable) accession number: Q758L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program