Reviewed, UniProtKB/Swiss-Prot Q758K0 (GGPPS_ASHGO)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:	BTS1
Ordered Locus Names:	AEL238C

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. May be involved in vesicle trafficking and protein sorting By similarity.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Isoprene biosynthesis Protein transport Transport
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Geranylgeranyl pyrophosphate synthetase		PRO_0000228138
Sites
	Active site	168	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q758K0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EFA9BE35C2F831BF	FASTA	320	35,984
	10 20 30 40 50 60 MDSVEGLALG PVIWTASQEE LLRQPYNHLV TQPGKNFRNT LIRVFNGFYG LSERQVAAVT 70 80 90 100 110 120 ELVEMLHVAS LLIDDIEDNS AWRRGVAAAH VVYGSPMTIN TANYMYFVSM SLLGQLAAQR 130 140 150 160 170 180 PAGPLQDLLK VFNEEMMNLH RGQGLDIYWR DTFTVPSEHD YLRMVMHKTG GLFRLTVRIM 190 200 210 220 230 240 EALREGPDGP GSTLVPLSNL LGVLYQVRDD YLNLTDSRMS ENKGFADDIT EGKFSYPIIH 250 260 270 280 290 300 GLQYARVHDP AGYDFLVSVL RQRTTDITTK RRVVRYLADV SGSLAYTKQR IIELATLIKT 310 320 KYIPASGTEL CNVIDSLTSF

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016818 Genomic DNA. Translation: AAS52447.1.
RefSeq	NP_984623.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4620805.
KEGG	ago:AGOS_AEL238C.
NMPDR	fig|33169.1.peg.2268.
Organism-specific databases
AGD	AEL238C.
Phylogenomic databases
HOGENOM	Q758K0.
OMA	Q758K0. ANYMYFV.
Enzyme and pathway databases
BRENDA	2.5.1.1. 279361. 2.5.1.10. 279361. 2.5.1.29. 279361.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGPPS_ASHGO

Accession

Primary (citable) accession number: Q758K0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)