Reviewed, UniProtKB/Swiss-Prot Q757U3 (ETR1_ASHGO)

Names and origin

Protein names

Recommended name:
    Probable trans-2-enoyl-CoA reductase, mitochondrial
    EC=1.3.1.38

Gene names

Name:	ETR1
Ordered Locus Names:	AEL081W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 376		Probable trans-2-enoyl-CoA reductase, mitochondrial		PRO_0000000896

Sequences

	Sequence		Length	Mass (Da)
	Q757U3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DFF107B8D6215ABE	FASTA	376	41,467
	10 20 30 40 50 60 MQALNTTKRL MSTKQFPLFK SLLYSSHDPA DCTQVLKVHS YTPKVGADES ILLRTLAFPI 70 80 90 100 110 120 NPSDINQLQG VYPSVPEKTL DYSTEKPAAI AGNEGVFEVM SVPQGERRLA VGDWVIPLYS 130 140 150 160 170 180 NTGTWTNYQT CRDAGTLVKV NGLDLYTAAT IAVNGCTAYQ LVNDYVQWDP SGNEWIVQNA 190 200 210 220 230 240 GTSAVSKIVT QVAQARGVKT LSVIRDRENF AEVAKELEER YGATKVISET QNNDKDFSKD 250 260 270 280 290 300 ELPVILGPNA RVRLALNSVG GKSSGAIARK LERDGTMLTY GGMSRQPVTV PTTLLIFNGL 310 320 330 340 350 360 KSLGYWITEN TKRNPQSKID TISVLMRMYG DGQLQPPEAD IKKIEWDVQK MNDEQLLEAV 370 KNGIQSNGKS VVVLKW

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS52604.1.
RefSeq	NP_984780.1.
3D structure databases
SMR	Q757U3. Positions 19-373.
ModBase	Search...
Protein-protein interaction databases
STRING	Q757U3.
Genome annotation databases
GeneID	4620970.
GenomeReviews	Gene locus AEL081W in contig AE016818_GR.
KEGG	ago:AGOS_AEL081W.
NMPDR	fig|33169.1.peg.2425.
Organism-specific databases
AGD	AEL081W.
Phylogenomic databases
eggNOG	fuNOG07814.
HOGENOM	HBG753318.
OMA	LQGVYPS.
OrthoDB	EOG9CNS7N.
Enzyme and pathway databases
BRENDA	1.3.1.38. 279361.
Family and domain databases
InterPro	IPR002085. ADH_SF_Zn. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ETR1_ASHGO

Accession

Primary (citable) accession number: Q757U3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)