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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

ETR1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donorBy similarity1
Binding sitei154NADPBy similarity1
Binding sitei369NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi182 – 185NADPBy similarity4
Nucleotide bindingi205 – 207NADPBy similarity3
Nucleotide bindingi280 – 283NADPBy similarity4
Nucleotide bindingi305 – 307NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
Name:ETR1
Ordered Locus Names:AEL081W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome V

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000896? – 376Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi33169.AAS52604.

Structurei

3D structure databases

ProteinModelPortaliQ757U3.
SMRiQ757U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ757U3.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG092C2NJA.

Family and domain databases

InterProiView protein in InterPro
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q757U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALNTTKRL MSTKQFPLFK SLLYSSHDPA DCTQVLKVHS YTPKVGADES
60 70 80 90 100
ILLRTLAFPI NPSDINQLQG VYPSVPEKTL DYSTEKPAAI AGNEGVFEVM
110 120 130 140 150
SVPQGERRLA VGDWVIPLYS NTGTWTNYQT CRDAGTLVKV NGLDLYTAAT
160 170 180 190 200
IAVNGCTAYQ LVNDYVQWDP SGNEWIVQNA GTSAVSKIVT QVAQARGVKT
210 220 230 240 250
LSVIRDRENF AEVAKELEER YGATKVISET QNNDKDFSKD ELPVILGPNA
260 270 280 290 300
RVRLALNSVG GKSSGAIARK LERDGTMLTY GGMSRQPVTV PTTLLIFNGL
310 320 330 340 350
KSLGYWITEN TKRNPQSKID TISALMRMYG DGQLQPPEAD IKKIEWDVQK
360 370
MNDEQLLEAV KNGIQSNGKS VVVLKW
Length:376
Mass (Da):41,439
Last modified:January 9, 2013 - v2
Checksum:iA8F107B8CF1CEC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52604.2.
RefSeqiNP_984780.2. NM_210134.2.

Genome annotation databases

EnsemblFungiiAAS52604; AAS52604; AGOS_AEL081W.
GeneIDi4620970.
KEGGiago:AGOS_AEL081W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiETR1_ASHGO
AccessioniPrimary (citable) accession number: Q757U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 9, 2013
Last modified: July 5, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families