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Q757U3 (ETR1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR1
Ordered Locus Names:AEL081W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 376Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000896

Regions

Nucleotide binding182 – 1854NADP By similarity
Nucleotide binding205 – 2073NADP By similarity
Nucleotide binding280 – 2834NADP By similarity
Nucleotide binding305 – 3073NADP By similarity

Sites

Binding site1541NADP By similarity
Binding site3691NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q757U3 [UniParc].

Last modified January 9, 2013. Version 2.
Checksum: A8F107B8CF1CEC7C

FASTA37641,439
        10         20         30         40         50         60 
MQALNTTKRL MSTKQFPLFK SLLYSSHDPA DCTQVLKVHS YTPKVGADES ILLRTLAFPI 

        70         80         90        100        110        120 
NPSDINQLQG VYPSVPEKTL DYSTEKPAAI AGNEGVFEVM SVPQGERRLA VGDWVIPLYS 

       130        140        150        160        170        180 
NTGTWTNYQT CRDAGTLVKV NGLDLYTAAT IAVNGCTAYQ LVNDYVQWDP SGNEWIVQNA 

       190        200        210        220        230        240 
GTSAVSKIVT QVAQARGVKT LSVIRDRENF AEVAKELEER YGATKVISET QNNDKDFSKD 

       250        260        270        280        290        300 
ELPVILGPNA RVRLALNSVG GKSSGAIARK LERDGTMLTY GGMSRQPVTV PTTLLIFNGL 

       310        320        330        340        350        360 
KSLGYWITEN TKRNPQSKID TISALMRMYG DGQLQPPEAD IKKIEWDVQK MNDEQLLEAV 

       370 
KNGIQSNGKS VVVLKW 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 324.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016818 Genomic DNA. Translation: AAS52604.2.
RefSeqNP_984780.2. NM_210134.2.

3D structure databases

ProteinModelPortalQ757U3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_AEL081W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4620970.
KEGGago:AGOS_AEL081W.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
KOK07512.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR1_ASHGO
AccessionPrimary (citable) accession number: Q757U3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 9, 2013
Last modified: March 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families