Q757Q0 (PGK_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	PGK1
Ordered Locus Names:	AEL038C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphoglycerate kinase family.
Sequence caution	The sequence AAS52647.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Phosphoglycerate kinase		PRO_0000145874
Regions
	Nucleotide binding	371 – 374	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	63 – 66	4	Substrate binding By similarity
Sites
	Binding site	39	1	Substrate By similarity
	Binding site	122	1	Substrate By similarity
	Binding site	169	1	Substrate By similarity
	Binding site	218	1	ATP By similarity
	Binding site	311	1	ATP; via carbonyl oxygen By similarity
	Binding site	342	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q757Q0 [UniParc]. Last modified January 9, 2013. Version 3. Checksum: C53E920FEFEFC3CD	FASTA	416	44,219
	10 20 30 40 50 60 MSLSSKLTVK DLSLAGKRVF IRVDFNVPLD GKTITSNQRI VAALPTIKYV LEQGPKAVVL 70 80 90 100 110 120 ASHLGRPNGE RNEKYSLAPV AAELEKLLGQ KVNFLDDCVG EHVTAAVNGA AAGSVFLLEN 130 140 150 160 170 180 LRFHIEEEGS RKVDGEKVKA SAEDVQKFRQ GLMSLADVYV NDAFGTAHRA HSSMVGFELP 190 200 210 220 230 240 ERAGGFLLSR ELEYFSKALE NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SIVIGGGMAF 250 260 270 280 290 300 TFKKVLENME IGNSIYDKAG AEIVPKLAEK AKKNGVKIVL PVDFVIGDDF SQDANTKIVS 310 320 330 340 350 360 ASEGIPSGWE GLDCGPESRK LFSETIASAK TIVWNGPPGV FEIPKFSEGT QAMLAAAVKA 370 380 390 400 410 SEAGSTVIIG GGDTATVAKK YGVVEKISHV STGGGASLEL LEGKDLPGVT FLSSKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	Dietrich F.S., Voegeli S., Philippsen P. Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 94-100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS52647.2. Different initiation.
RefSeq	NP_984823.2. NM_210177.2.
3D structure databases
ProteinModelPortal	Q757Q0.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_AEL038C.
Proteomic databases
PRIDE	Q757Q0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4621019.
KEGG	ago:AGOS_AEL038C.
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OrthoDB	EOG4F4WKK.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_ASHGO

Accession

Primary (citable) accession number: Q757Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program