Q757L1 (TREB_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable trehalase
EC=3.2.1.28

Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase

Gene names

Name:	NTH2
Ordered Locus Names:	AER001C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 37 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	trehalose catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: EnsemblFungi
Molecular_function	alpha,alpha-trehalase activity Inferred from electronic annotation. Source: EC calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 738	738	Probable trehalase		PRO_0000173799

Sequences

	Sequence		Length	Mass (Da)
	Q757L1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 16DA18085F1700C7	FASTA	738	84,487
	10 20 30 40 50 60 MLQGMPKRSG SISELHDPFS SPDVYYGPAT DPRRQKQPNK YSRTRTMSII ENVSTFKSAG 70 80 90 100 110 120 KQYNIRRRGS EDDSMLASSG HRKFYIKDVD KTLEELLESE DTDGNYQITI EDRGPKTLRV 130 140 150 160 170 180 GTANSNGFRH VQIRGTYMLS NLLQELTIAK NFGRKQVILD EARLNEDPVN RLTRLITHQF 190 200 210 220 230 240 WDSLTRRIDY NSIAAIAADT KVDTPGAKVP RIYVPHGCPE QYEYFIECSQ LNPSLNLEVK 250 260 270 280 290 300 YLPDVITPEH VQSLNESPGL LALAMESHRD PITGESTLVG FPYVVPGGRF NELYGWDSYL 310 320 330 340 350 360 MALGLLDCNK VDIARGMVEH FIFEIEHYGK ILNANRSYYL CRSQPPFLTD MALKVFEKFG 370 380 390 400 410 420 GDQNPTAVDF LKRAFIAAIK EYKSVWMAEP RYDKTTGLSC YHPDGIGFPP ETEPDHFDAI 430 440 450 460 470 480 CRKFAEKHNV TIPEFRCMYD AGEVHEPELD EFFLHDRAVR ESGHDTSYRL ENVCAYLATI 490 500 510 520 530 540 DLNSLLYKYE KDIAYVVSKY FDDSITDYAG ETTTSSHWEA LADIRKQRIT KYLWDEETGF 550 560 570 580 590 600 FYDYNVHIGK RTSYDSATTF WAMWAGLATQ EQANAMVEKA LPRLEMLGGL VACTEESRGE 610 620 630 640 650 660 ITMNRPSRQW DYPYGWAPHQ MLAWTGLDNY GFTGVARRLA YRWLFLMTKA FVDYNGIVVE 670 680 690 700 710 720 KYDVTRGTDP HRVDAEYGNQ GADFKGVATE GFGWVNSSYI LGLKFMNTYA KRALANCTVP 730 DIFFKHMKPE EKARYALI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	"Isolation and functional analysis of centromeric DNA of the filamentous ascomycete Ashbya gossypii." Wendland J., Dietrich F.S., Mohr C., Philippsen P. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 246-738. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS52685.1. AF384989 Genomic DNA. Translation: AAO15410.1.
RefSeq	NP_984861.1. NM_210215.1.
3D structure databases
ProteinModelPortal	Q757L1.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_AER001C.
Protein family/group databases
CAZy	GH37. Glycoside Hydrolase Family 37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	AAS52685; AAS52685; AGOS_AER001C.
GeneID	4621060.
KEGG	ago:AGOS_AER001C.
Phylogenomic databases
eggNOG	COG1626.
HOGENOM	HOG000192885.
KO	K01194.
OMA	RQWDYPY.
OrthoDB	EOG4WQ49Q.
PhylomeDB	Q757L1.
Family and domain databases
InterPro	IPR008928. 6-hairpin_glycosidase-like. IPR001661. Glyco_hydro_37. IPR018232. Glyco_hydro_37_CS. IPR011120. Trehalase_Ca-bd. [Graphical view]
PANTHER	PTHR23403. PTHR23403. 1 hit.
Pfam	PF01204. Trehalase. 1 hit. PF07492. Trehalase_Ca-bi. 1 hit. [Graphical view]
PRINTS	PR00744. GLHYDRLASE37.
SUPFAM	SSF48208. Glyco_trans_6hp. 1 hit.
PROSITE	PS00927. TREHALASE_1. 1 hit. PS00928. TREHALASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TREB_ASHGO

Accession

Primary (citable) accession number: Q757L1
Secondary accession number(s): Q8J1F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program