Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GPI mannosyltransferase 2

Gene

GPI18

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 2 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase II
Short name:
GPI-MT-II
Glycosylphosphatidylinositol-anchor biosynthesis protein 18
Gene namesi
Name:GPI18
Ordered Locus Names:AER005C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome V

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427GPI mannosyltransferase 2PRO_0000246239Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGV family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000248561.
InParanoidiQ757K7.
KOiK07542.
OMAiSIYGWVQ.
OrthoDBiEOG7V4B80.

Family and domain databases

InterProiIPR007315. PIG-V/Gpi18.
[Graphical view]
PANTHERiPTHR12468. PTHR12468. 1 hit.
PfamiPF04188. Mannosyl_trans2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q757K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECFKRLTTV FFTVKLVQYL LVYFAPGQFD TSTPLFLEKY QPLQPEKWYH
60 70 80 90 100
KLLSWDSVYF VKNGLQAVTH TNAYGYVSLP EYEHEWMFSP FVWSQTLKTA
110 120 130 140 150
GGATLRNWAA PIDTLLVRAT LLNLVLHYVS VWLLYALTLR TFPKNRELAY
160 170 180 190 200
KTSLLFILSS AAGFLLAPYS EPLSFAFSFL GMLLRMLAVE HNVYGGITLA
210 220 230 240 250
WYNWLPYTLS GICFSVAAAN RPNCVLLGVY YIYDVLKLVR QRNWVRAVLF
260 270 280 290 300
PCIAGSMMLG IFAYMHYYLP SVVFCPERES WCKHSLPWIH IPYKSFYSFV
310 320 330 340 350
QGYYWRNGFL NYWTWNNVPN FLFALPNLVI LWYSTVYFSY QYPLESIRPL
360 370 380 390 400
VYITRALLLI ITFFAHVQII NRISSFIPLH LWYLSDRMIK TTGEAKGDDR
410 420
LVYLYVNWLI LWIPLQTVLF ACFLPPA
Length:427
Mass (Da):50,042
Last modified:July 5, 2004 - v1
Checksum:i7303E7717E84D48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52689.1.
RefSeqiNP_984865.1. NM_210219.1.

Genome annotation databases

EnsemblFungiiAAS52689; AAS52689; AGOS_AER005C.
GeneIDi4621064.
KEGGiago:AGOS_AER005C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52689.1.
RefSeqiNP_984865.1. NM_210219.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS52689; AAS52689; AGOS_AER005C.
GeneIDi4621064.
KEGGiago:AGOS_AER005C.

Phylogenomic databases

HOGENOMiHOG000248561.
InParanoidiQ757K7.
KOiK07542.
OMAiSIYGWVQ.
OrthoDBiEOG7V4B80.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR007315. PIG-V/Gpi18.
[Graphical view]
PANTHERiPTHR12468. PTHR12468. 1 hit.
PfamiPF04188. Mannosyl_trans2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiGPI18_ASHGO
AccessioniPrimary (citable) accession number: Q757K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: February 17, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.