ID   COX9_EREGS              Reviewed;          60 AA.
AC   Q757F0;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=Cytochrome c oxidase subunit 9, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide VIIA;
DE   Flags: Precursor;
GN   Name=COX9; OrderedLocusNames=AER063W;
OS   Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
OS   Y-1056) (Yeast) (Ashbya gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P07255}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P07255}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of a catalytic core of 3 subunits and
CC       several supernumerary subunits. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC       complex, complex III, CIII). {ECO:0000250|UniProtKB:P07255}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P07255}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P07255}.
CC   -!- SIMILARITY: Belongs to the fungal cytochrome c oxidase subunit 7a
CC       family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52747.1; -; Genomic_DNA.
DR   RefSeq; NP_984923.1; NM_210277.1.
DR   AlphaFoldDB; Q757F0; -.
DR   SMR; Q757F0; -.
DR   STRING; 284811.Q757F0; -.
DR   EnsemblFungi; AAS52747; AAS52747; AGOS_AER063W.
DR   GeneID; 4621126; -.
DR   KEGG; ago:AGOS_AER063W; -.
DR   eggNOG; ENOG502SBM8; Eukaryota.
DR   HOGENOM; CLU_196969_0_0_1; -.
DR   InParanoid; Q757F0; -.
DR   OMA; ASYWWWG; -.
DR   OrthoDB; 1385898at2759; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:GOC.
DR   CDD; cd22888; CcO_VIIa_fungal; 1.
DR   InterPro; IPR014368; Cyt_c_oxidase_su7a_fun.
DR   PANTHER; PTHR28264:SF1; CYTOCHROME C OXIDASE SUBUNIT 6C; 1.
DR   PANTHER; PTHR28264; CYTOCHROME C OXIDASE SUBUNIT 7A; 1.
DR   PIRSF; PIRSF000283; COX9; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..57
FT                   /note="Cytochrome c oxidase subunit 9, mitochondrial"
FT                   /id="PRO_0000041763"
FT   PROPEP          58..60
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250|UniProtKB:P07255"
FT                   /id="PRO_0000041764"
FT   TOPO_DOM        1..18
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P07255"
FT   TRANSMEM        19..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..57
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P07255"
SQ   SEQUENCE   60 AA;  6714 MW;  7089BF0AA36815B6 CRC64;
     MSAIAPITGS LKKRIMKDIA VGMGLGTVLG SYWWWGFHKP KIAARENYYT QLAEQKAAEE
//