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Q75760

- Q75760_9HIV1

UniProt

Q75760 - Q75760_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi298 – 2981N-linked (GlcNAc...)Imported

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P848012EBI-8453491,EBI-8453570From a different organism.
athQ9KWN02EBI-8453491,EBI-8453511From a different organism.
UDA1P112182EBI-8453491,EBI-8453649From a different organism.

Protein-protein interaction databases

DIPiDIP-59960N.
IntActiQ75760. 3 interactions.
MINTiMINT-8414778.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TJGX-ray2.00P653-659[»]
2B4CX-ray3.30G82-483[»]
2F5BX-ray2.00P653-659[»]
3TYGX-ray3.25A295-325[»]
4JM2X-ray3.10E88-483[»]
ProteinModelPortaliQ75760.
SMRiQ75760. Positions 82-483, 503-656.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ75760.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q75760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVKGIRKSY QYLWKGGTLL LGILMICSAV EKLWVTVYYG VPVWKEATTT
60 70 80 90 100
LFCASDAKAY DTEVHNVWAT HACVPTDPNP QEVVLENVTE HFNMWKNNMV
110 120 130 140 150
EQMQEDIISL WDQSLKPCVK LTPLCVTLNC KDVNATNTTN DSEGTMERGE
160 170 180 190 200
IKNCSFNITT SIRDEVQKEY ALFYKLDVVP IDNNNTSYRL ISCDTSVITQ
210 220 230 240 250
ACPKISFEPI PIHYCAPAGF AILKCNDKTF NGKGPCKNVS TVQCTHGIRP
260 270 280 290 300
VVSTQLLLNG SLAEEEVVIR SDNFTNNAKT IIVQLKESVE INCTRPNNNT
310 320 330 340 350
RKSIHIGPGR AFYTTGEIIG DIRQAHCNIS RAKWNDTLKQ IVIKLREQFE
360 370 380 390 400
NKTIVFNHSS GGDPEIVMHS FNCGGEFFYC NSTQLFNSTW NNNTEGSNNT
410 420 430 440 450
EGNTITLPCR IKQIINMWQE VGKAMYAPPI RGQIRCSSNI TGLLLTRDGG
460 470 480 490 500
INENGTEIFR PGGGDMRDNW RSELYKYKVV KIEPLGVAPT KAKRRVVQRE
510 520 530 540 550
KRAVGIGAVF LGFLGAAGST MGAASMTLTV QARLLLSGIV QQQNNLLRAI
560 570 580 590 600
EAQQRMLQLT VWGIKQLQAR VLAVERYLGD QQLLGIWGCS GKLICTTAVP
610 620 630 640 650
WNASWSNKSL DRIWNNMTWM EWEREIDNYT SEIYTLIEES QNQQEKNEQE
660 670 680 690 700
LLELDKWASL WNWFDITKWL WYIKIFIMIV GGLVGLRLVF TVLSIVNRVR
710 720 730 740 750
QGYSPLSFQT LLPAPRGPDR PEGIEEEGGE RDRDRSGRLV NGFLALIWVD
760 770 780 790 800
LRSLCLFSYH RLRDLLLTVT RIVELLGRRG WEVLKYWWNL LQYWSQELKN
810 820 830 840
SAVSLLNATA IAVAEGTDRI IEALQRTYRA ILHIPTRIRQ GLERALL
Length:847
Mass (Da):96,160
Last modified:November 1, 1996 - v1
Checksum:i022D5F24E04FB29F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63632 Genomic DNA. Translation: AAB05604.1.
PIRiS13289.
T09448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63632 Genomic DNA. Translation: AAB05604.1 .
PIRi S13289.
T09448.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TJG X-ray 2.00 P 653-659 [» ]
2B4C X-ray 3.30 G 82-483 [» ]
2F5B X-ray 2.00 P 653-659 [» ]
3TYG X-ray 3.25 A 295-325 [» ]
4JM2 X-ray 3.10 E 88-483 [» ]
ProteinModelPortali Q75760.
SMRi Q75760. Positions 82-483, 503-656.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59960N.
IntActi Q75760. 3 interactions.
MINTi MINT-8414778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q75760.

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms."
    Koyanagi Y., Miles S., Mitsuyasu R.T., Merrill J.E., Vinters H.V., Chen I.S.
    Science 236:819-822(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JRFLImported.
    Tissue: BrainImported.
  2. "HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain."
    O'Brien W.A., Koyanagi Y., Namazie A., Zhao J.Q., Diagne A., Idler K., Zack J.A., Chen I.S.
    Nature 348:69-73(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JRFLImported.
    Tissue: BrainImported.
  3. "HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease."
    Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S.
    J. Acquir. Immune Defic. Syndr. 4:1082-1092(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JRFLImported.
    Tissue: BrainImported.
  4. Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S., Koyanagi Y., Namazie A., Zhao J., Diagne A., Idler K.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JRFLImported.
    Tissue: BrainImported.
  5. "Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope."
    Ofek G., Tang M., Sambor A., Katinger H., Mascola J.R., Wyatt R., Kwong P.D.
    J. Virol. 78:10724-10737(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 82-483.
  7. "Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications."
    Bryson S., Julien J.P., Hynes R.C., Pai E.F.
    J. Virol. 83:11862-11875(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 318-394, GLYCOSYLATION AT ASN-298.
  9. "Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120."
    Kong L., Lee J.H., Doores K.J., Murin C.D., Julien J.P., McBride R., Liu Y., Marozsan A., Cupo A., Klasse P.J., Hoffenberg S., Caulfield M., King C.R., Hua Y., Le K.M., Khayat R., Deller M.C., Clayton T.
    , Tien H., Feizi T., Sanders R.W., Paulson J.C., Moore J.P., Stanfield R.L., Burton D.R., Ward A.B., Wilson I.A.
    Nat. Struct. Mol. Biol. 20:796-803(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 88-483.

Entry informationi

Entry nameiQ75760_9HIV1
AccessioniPrimary (citable) accession number: Q75760
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3