Q75760 (Q75760_9HIV1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Envelope glycoprotein gp160 RuleBase RU004292

Gene names

Name:

env EMBL AAB05604.1

Organism

Human immunodeficiency virus 1 EMBL AAB05604.1

Taxonomic identifier

11676 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	847 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Ontologies

Keywords
Biological process	Apoptosis SAAS SAAS000328 Fusion of virus membrane with host membrane SAAS SAAS000328 Host-virus interaction Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328 Viral immunoevasion RuleBase RU004292 Viral penetration into host cytoplasm Virus entry into host cell
Cellular component	Host cell membrane SAAS SAAS000328 Host endosome SAAS SAAS000328 Host membrane Membrane Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AAB05604.1 Virion
Disease	AIDS RuleBase RU003294
Domain	Transmembrane Transmembrane helix SAAS SAAS000328
PTM	Cleavage on pair of basic residues RuleBase RU004292 Disulfide bond SAAS SAAS000328
Technical term	3D-structure PDB 1TJG PDB 3TYG PDB 2B4C
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW evasion or tolerance by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endosome Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Glycosylation	259	1	N-linked (GlcNAc...) PDB 2B4C
	Glycosylation	357	1	N-linked (GlcNAc...) PDB 2B4C

Sequences

	Sequence		Length	Mass (Da)
	Q75760 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 022D5F24E04FB29F	FASTA	847	96,160
	10 20 30 40 50 60 MRVKGIRKSY QYLWKGGTLL LGILMICSAV EKLWVTVYYG VPVWKEATTT LFCASDAKAY 70 80 90 100 110 120 DTEVHNVWAT HACVPTDPNP QEVVLENVTE HFNMWKNNMV EQMQEDIISL WDQSLKPCVK 130 140 150 160 170 180 LTPLCVTLNC KDVNATNTTN DSEGTMERGE IKNCSFNITT SIRDEVQKEY ALFYKLDVVP 190 200 210 220 230 240 IDNNNTSYRL ISCDTSVITQ ACPKISFEPI PIHYCAPAGF AILKCNDKTF NGKGPCKNVS 250 260 270 280 290 300 TVQCTHGIRP VVSTQLLLNG SLAEEEVVIR SDNFTNNAKT IIVQLKESVE INCTRPNNNT 310 320 330 340 350 360 RKSIHIGPGR AFYTTGEIIG DIRQAHCNIS RAKWNDTLKQ IVIKLREQFE NKTIVFNHSS 370 380 390 400 410 420 GGDPEIVMHS FNCGGEFFYC NSTQLFNSTW NNNTEGSNNT EGNTITLPCR IKQIINMWQE 430 440 450 460 470 480 VGKAMYAPPI RGQIRCSSNI TGLLLTRDGG INENGTEIFR PGGGDMRDNW RSELYKYKVV 490 500 510 520 530 540 KIEPLGVAPT KAKRRVVQRE KRAVGIGAVF LGFLGAAGST MGAASMTLTV QARLLLSGIV 550 560 570 580 590 600 QQQNNLLRAI EAQQRMLQLT VWGIKQLQAR VLAVERYLGD QQLLGIWGCS GKLICTTAVP 610 620 630 640 650 660 WNASWSNKSL DRIWNNMTWM EWEREIDNYT SEIYTLIEES QNQQEKNEQE LLELDKWASL 670 680 690 700 710 720 WNWFDITKWL WYIKIFIMIV GGLVGLRLVF TVLSIVNRVR QGYSPLSFQT LLPAPRGPDR 730 740 750 760 770 780 PEGIEEEGGE RDRDRSGRLV NGFLALIWVD LRSLCLFSYH RLRDLLLTVT RIVELLGRRG 790 800 810 820 830 840 WEVLKYWWNL LQYWSQELKN SAVSLLNATA IAVAEGTDRI IEALQRTYRA ILHIPTRIRQ GLERALL

References

[1]	"Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms." Koyanagi Y., Miles S., Mitsuyasu R.T., Merrill J.E., Vinters H.V., Chen I.S. Science 236:819-822(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: JRFL EMBL AAB05604.1. Tissue: Brain EMBL AAB05604.1.
[2]	"HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain." O'Brien W.A., Koyanagi Y., Namazie A., Zhao J.Q., Diagne A., Idler K., Zack J.A., Chen I.S. Nature 348:69-73(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: JRFL EMBL AAB05604.1. Tissue: Brain EMBL AAB05604.1.
[3]	"HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease." Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S. J. Acquir. Immune Defic. Syndr. 4:1082-1092(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: JRFL EMBL AAB05604.1. Tissue: Brain EMBL AAB05604.1.
[4]	Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S., Koyanagi Y., Namazie A., Zhao J., Diagne A., Idler K. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: JRFL EMBL AAB05604.1. Tissue: Brain EMBL AAB05604.1.
[5]	"Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope." Ofek G., Tang M., Sambor A., Katinger H., Mascola J.R., Wyatt R., Kwong P.D. J. Virol. 78:10724-10737(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
[6]	"Structure of a V3-containing HIV-1 gp120 core." Huang C.C., Tang M., Zhang M.Y., Majeed S., Montabana E., Stanfield R.L., Dimitrov D.S., Korber B., Sodroski J., Wilson I.A., Wyatt R., Kwong P.D. Science 310:1025-1028(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 82-483, GLYCOSYLATION AT ASN-259 AND ASN-357.
[7]	"A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield." Pejchal R., Doores K.J., Walker L.M., Khayat R., Huang P.S., Wang S.K., Stanfield R.L., Julien J.P., Ramos A., Crispin M., Depetris R., Katpally U., Marozsan A., Cupo A., Maloveste S., Liu Y., McBride R., Ito Y. , Sanders R.W., Ogohara C., Paulson J.C., Feizi T., Scanlan C.N., Wong C.H., Moore J.P., Olson W.C., Ward A.B., Poignard P., Schief W.R., Burton D.R., Wilson I.A. Science 334:1097-1103(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 436-468.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U63632 Genomic DNA. Translation: AAB05604.1.

PIR

S13289.
T09448.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TJG	X-ray	2.00	P	653-659	[»]
2B4C	X-ray	3.30	G	82-483	[»]
3TYG	X-ray	3.25	A	436-468	[»]

ProteinModelPortal

Q75760.

SMR

Q75760. Positions 82-483, 503-656.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59960N.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.170.40.20. 2 hits.

InterPro

IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]

Pfam

PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]

SUPFAM

SSF56502. GP120. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q75760.

Entry information

Entry name

Q75760_9HIV1

Accession

Primary (citable) accession number: Q75760

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)