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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalUniRule annotationAdd BLAST19
Transmembranei503 – 526HelicalUniRule annotationAdd BLAST24
Transmembranei669 – 690HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 73Combined sources
Disulfide bondi118 ↔ 202Combined sources
Disulfide bondi125 ↔ 193Combined sources
Disulfide bondi130 ↔ 154Combined sources
Disulfide bondi215 ↔ 244Combined sources
Disulfide bondi225 ↔ 236Combined sources
Disulfide bondi293 ↔ 327Combined sources
GlycosylationiCAR_5005389999298N-linked (GlcNAc...)Combined sources1
Disulfide bondi373 ↔ 436Combined sources
Disulfide bondi380 ↔ 409Combined sources

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Protein-protein interaction databases

DIPiDIP-59960N.
IntActiQ75760. 3 interactors.
MINTiMINT-8414778.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJGX-ray2.00P653-659[»]
2B4CX-ray3.30G82-483[»]
2F5BX-ray2.00P653-659[»]
3TYGX-ray3.25A295-325[»]
4JM2X-ray3.10E88-483[»]
5FYKX-ray3.11B503-655[»]
G30-497[»]
ProteinModelPortaliQ75760.
SMRiQ75760.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ75760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 141GP120InterPro annotationAdd BLAST109
Domaini146 – 502GP120InterPro annotationAdd BLAST357
Domaini521 – 711GP41InterPro annotationAdd BLAST191

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKGIRKSY QYLWKGGTLL LGILMICSAV EKLWVTVYYG VPVWKEATTT
60 70 80 90 100
LFCASDAKAY DTEVHNVWAT HACVPTDPNP QEVVLENVTE HFNMWKNNMV
110 120 130 140 150
EQMQEDIISL WDQSLKPCVK LTPLCVTLNC KDVNATNTTN DSEGTMERGE
160 170 180 190 200
IKNCSFNITT SIRDEVQKEY ALFYKLDVVP IDNNNTSYRL ISCDTSVITQ
210 220 230 240 250
ACPKISFEPI PIHYCAPAGF AILKCNDKTF NGKGPCKNVS TVQCTHGIRP
260 270 280 290 300
VVSTQLLLNG SLAEEEVVIR SDNFTNNAKT IIVQLKESVE INCTRPNNNT
310 320 330 340 350
RKSIHIGPGR AFYTTGEIIG DIRQAHCNIS RAKWNDTLKQ IVIKLREQFE
360 370 380 390 400
NKTIVFNHSS GGDPEIVMHS FNCGGEFFYC NSTQLFNSTW NNNTEGSNNT
410 420 430 440 450
EGNTITLPCR IKQIINMWQE VGKAMYAPPI RGQIRCSSNI TGLLLTRDGG
460 470 480 490 500
INENGTEIFR PGGGDMRDNW RSELYKYKVV KIEPLGVAPT KAKRRVVQRE
510 520 530 540 550
KRAVGIGAVF LGFLGAAGST MGAASMTLTV QARLLLSGIV QQQNNLLRAI
560 570 580 590 600
EAQQRMLQLT VWGIKQLQAR VLAVERYLGD QQLLGIWGCS GKLICTTAVP
610 620 630 640 650
WNASWSNKSL DRIWNNMTWM EWEREIDNYT SEIYTLIEES QNQQEKNEQE
660 670 680 690 700
LLELDKWASL WNWFDITKWL WYIKIFIMIV GGLVGLRLVF TVLSIVNRVR
710 720 730 740 750
QGYSPLSFQT LLPAPRGPDR PEGIEEEGGE RDRDRSGRLV NGFLALIWVD
760 770 780 790 800
LRSLCLFSYH RLRDLLLTVT RIVELLGRRG WEVLKYWWNL LQYWSQELKN
810 820 830 840
SAVSLLNATA IAVAEGTDRI IEALQRTYRA ILHIPTRIRQ GLERALL
Length:847
Mass (Da):96,160
Last modified:November 1, 1996 - v1
Checksum:i022D5F24E04FB29F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63632 Genomic DNA. Translation: AAB05604.1.
PIRiS13289.
T09448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63632 Genomic DNA. Translation: AAB05604.1.
PIRiS13289.
T09448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJGX-ray2.00P653-659[»]
2B4CX-ray3.30G82-483[»]
2F5BX-ray2.00P653-659[»]
3TYGX-ray3.25A295-325[»]
4JM2X-ray3.10E88-483[»]
5FYKX-ray3.11B503-655[»]
G30-497[»]
ProteinModelPortaliQ75760.
SMRiQ75760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59960N.
IntActiQ75760. 3 interactors.
MINTiMINT-8414778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ75760.

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ75760_9HIV1
AccessioniPrimary (citable) accession number: Q75760
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.