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Q75760 (Q75760_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein gp160 RuleBase RU004292
Gene names
Name:env EMBL AAB05604.1
OrganismHuman immunodeficiency virus 1 EMBL AAB05604.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length847 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity.

Ontologies

Keywords
   Biological processApoptosis SAAS SAAS000328
Fusion of virus membrane with host membrane SAAS SAAS000328
Host-virus interaction
Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328
Viral immunoevasion RuleBase RU004292
Viral penetration into host cytoplasm
Virus entry into host cell
   Cellular componentHost cell membrane SAAS SAAS000328
Host endosome SAAS SAAS000328
Host membrane
Membrane
Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AAB05604.1
Virion
   DiseaseAIDS RuleBase RU003294
   DomainTransmembrane
Transmembrane helix SAAS SAAS000328
   PTMCleavage on pair of basic residues RuleBase RU004292
Disulfide bond SAAS SAAS000328
   Technical term3D-structure PDB 4JM2 PDB 1TJG PDB 3TYG PDB 2B4C
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

evasion or tolerance by virus of host immune response

Inferred from electronic annotation. Source: UniProtKB-KW

membrane fusion involved in viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P848012EBI-8453491,EBI-8453570From a different organism.
athQ9KWN02EBI-8453491,EBI-8453511From a different organism.
UDA1P112182EBI-8453491,EBI-8453649From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Glycosylation2981N-linked (GlcNAc...) PDB 3TYG

Sequences

Sequence LengthMass (Da)Tools
Q75760 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 022D5F24E04FB29F

FASTA84796,160
        10         20         30         40         50         60 
MRVKGIRKSY QYLWKGGTLL LGILMICSAV EKLWVTVYYG VPVWKEATTT LFCASDAKAY 

        70         80         90        100        110        120 
DTEVHNVWAT HACVPTDPNP QEVVLENVTE HFNMWKNNMV EQMQEDIISL WDQSLKPCVK 

       130        140        150        160        170        180 
LTPLCVTLNC KDVNATNTTN DSEGTMERGE IKNCSFNITT SIRDEVQKEY ALFYKLDVVP 

       190        200        210        220        230        240 
IDNNNTSYRL ISCDTSVITQ ACPKISFEPI PIHYCAPAGF AILKCNDKTF NGKGPCKNVS 

       250        260        270        280        290        300 
TVQCTHGIRP VVSTQLLLNG SLAEEEVVIR SDNFTNNAKT IIVQLKESVE INCTRPNNNT 

       310        320        330        340        350        360 
RKSIHIGPGR AFYTTGEIIG DIRQAHCNIS RAKWNDTLKQ IVIKLREQFE NKTIVFNHSS 

       370        380        390        400        410        420 
GGDPEIVMHS FNCGGEFFYC NSTQLFNSTW NNNTEGSNNT EGNTITLPCR IKQIINMWQE 

       430        440        450        460        470        480 
VGKAMYAPPI RGQIRCSSNI TGLLLTRDGG INENGTEIFR PGGGDMRDNW RSELYKYKVV 

       490        500        510        520        530        540 
KIEPLGVAPT KAKRRVVQRE KRAVGIGAVF LGFLGAAGST MGAASMTLTV QARLLLSGIV 

       550        560        570        580        590        600 
QQQNNLLRAI EAQQRMLQLT VWGIKQLQAR VLAVERYLGD QQLLGIWGCS GKLICTTAVP 

       610        620        630        640        650        660 
WNASWSNKSL DRIWNNMTWM EWEREIDNYT SEIYTLIEES QNQQEKNEQE LLELDKWASL 

       670        680        690        700        710        720 
WNWFDITKWL WYIKIFIMIV GGLVGLRLVF TVLSIVNRVR QGYSPLSFQT LLPAPRGPDR 

       730        740        750        760        770        780 
PEGIEEEGGE RDRDRSGRLV NGFLALIWVD LRSLCLFSYH RLRDLLLTVT RIVELLGRRG 

       790        800        810        820        830        840 
WEVLKYWWNL LQYWSQELKN SAVSLLNATA IAVAEGTDRI IEALQRTYRA ILHIPTRIRQ 


GLERALL 

« Hide

References

[1]"Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms."
Koyanagi Y., Miles S., Mitsuyasu R.T., Merrill J.E., Vinters H.V., Chen I.S.
Science 236:819-822(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JRFL EMBL AAB05604.1.
Tissue: Brain EMBL AAB05604.1.
[2]"HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain."
O'Brien W.A., Koyanagi Y., Namazie A., Zhao J.Q., Diagne A., Idler K., Zack J.A., Chen I.S.
Nature 348:69-73(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JRFL EMBL AAB05604.1.
Tissue: Brain EMBL AAB05604.1.
[3]"HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease."
Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S.
J. Acquir. Immune Defic. Syndr. 4:1082-1092(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JRFL EMBL AAB05604.1.
Tissue: Brain EMBL AAB05604.1.
[4]Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S., Koyanagi Y., Namazie A., Zhao J., Diagne A., Idler K.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JRFL EMBL AAB05604.1.
Tissue: Brain EMBL AAB05604.1.
[5]"Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope."
Ofek G., Tang M., Sambor A., Katinger H., Mascola J.R., Wyatt R., Kwong P.D.
J. Virol. 78:10724-10737(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
[6]"Structure of a V3-containing HIV-1 gp120 core."
Huang C.C., Tang M., Zhang M.Y., Majeed S., Montabana E., Stanfield R.L., Dimitrov D.S., Korber B., Sodroski J., Wilson I.A., Wyatt R., Kwong P.D.
Science 310:1025-1028(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 82-483.
[7]"A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield."
Pejchal R., Doores K.J., Walker L.M., Khayat R., Huang P.S., Wang S.K., Stanfield R.L., Julien J.P., Ramos A., Crispin M., Depetris R., Katpally U., Marozsan A., Cupo A., Maloveste S., Liu Y., McBride R., Ito Y. expand/collapse author list , Sanders R.W., Ogohara C., Paulson J.C., Feizi T., Scanlan C.N., Wong C.H., Moore J.P., Olson W.C., Ward A.B., Poignard P., Schief W.R., Burton D.R., Wilson I.A.
Science 334:1097-1103(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 295-325, GLYCOSYLATION AT ASN-298.
[8]"Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120."
Kong L., Lee J.H., Doores K.J., Murin C.D., Julien J.P., McBride R., Liu Y., Marozsan A., Cupo A., Klasse P.J., Hoffenberg S., Caulfield M., King C.R., Hua Y., Le K.M., Khayat R., Deller M.C., Clayton T. expand/collapse author list , Tien H., Feizi T., Sanders R.W., Paulson J.C., Moore J.P., Stanfield R.L., Burton D.R., Ward A.B., Wilson I.A.
Nat. Struct. Mol. Biol. 20:796-803(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 88-483.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63632 Genomic DNA. Translation: AAB05604.1.
PIRS13289.
T09448.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1TJGX-ray2.00P653-659[»]
2B4CX-ray3.30G82-483[»]
3TYGX-ray3.25A295-325[»]
4JM2X-ray3.10E88-483[»]
ProteinModelPortalQ75760.
SMRQ75760. Positions 82-483, 503-656.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59960N.
IntActQ75760. 3 interactions.
MINTMINT-8414778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceQ75760.

Entry information

Entry nameQ75760_9HIV1
AccessionPrimary (citable) accession number: Q75760
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)