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Q75760

- Q75760_9HIV1

UniProt

Q75760 - Q75760_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi298 – 2981N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P848012EBI-8453491,EBI-8453570From a different organism.
    athQ9KWN02EBI-8453491,EBI-8453511From a different organism.
    UDA1P112182EBI-8453491,EBI-8453649From a different organism.

    Protein-protein interaction databases

    DIPiDIP-59960N.
    IntActiQ75760. 3 interactions.
    MINTiMINT-8414778.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TJGX-ray2.00P653-659[»]
    2B4CX-ray3.30G82-483[»]
    2F5BX-ray2.00P653-659[»]
    3TYGX-ray3.25A251-272[»]
    A341-386[»]
    4JM2X-ray3.10E88-483[»]
    ProteinModelPortaliQ75760.
    SMRiQ75760. Positions 82-483, 503-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ75760.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q75760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVKGIRKSY QYLWKGGTLL LGILMICSAV EKLWVTVYYG VPVWKEATTT    50
    LFCASDAKAY DTEVHNVWAT HACVPTDPNP QEVVLENVTE HFNMWKNNMV 100
    EQMQEDIISL WDQSLKPCVK LTPLCVTLNC KDVNATNTTN DSEGTMERGE 150
    IKNCSFNITT SIRDEVQKEY ALFYKLDVVP IDNNNTSYRL ISCDTSVITQ 200
    ACPKISFEPI PIHYCAPAGF AILKCNDKTF NGKGPCKNVS TVQCTHGIRP 250
    VVSTQLLLNG SLAEEEVVIR SDNFTNNAKT IIVQLKESVE INCTRPNNNT 300
    RKSIHIGPGR AFYTTGEIIG DIRQAHCNIS RAKWNDTLKQ IVIKLREQFE 350
    NKTIVFNHSS GGDPEIVMHS FNCGGEFFYC NSTQLFNSTW NNNTEGSNNT 400
    EGNTITLPCR IKQIINMWQE VGKAMYAPPI RGQIRCSSNI TGLLLTRDGG 450
    INENGTEIFR PGGGDMRDNW RSELYKYKVV KIEPLGVAPT KAKRRVVQRE 500
    KRAVGIGAVF LGFLGAAGST MGAASMTLTV QARLLLSGIV QQQNNLLRAI 550
    EAQQRMLQLT VWGIKQLQAR VLAVERYLGD QQLLGIWGCS GKLICTTAVP 600
    WNASWSNKSL DRIWNNMTWM EWEREIDNYT SEIYTLIEES QNQQEKNEQE 650
    LLELDKWASL WNWFDITKWL WYIKIFIMIV GGLVGLRLVF TVLSIVNRVR 700
    QGYSPLSFQT LLPAPRGPDR PEGIEEEGGE RDRDRSGRLV NGFLALIWVD 750
    LRSLCLFSYH RLRDLLLTVT RIVELLGRRG WEVLKYWWNL LQYWSQELKN 800
    SAVSLLNATA IAVAEGTDRI IEALQRTYRA ILHIPTRIRQ GLERALL 847
    Length:847
    Mass (Da):96,160
    Last modified:November 1, 1996 - v1
    Checksum:i022D5F24E04FB29F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63632 Genomic DNA. Translation: AAB05604.1.
    PIRiS13289.
    T09448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63632 Genomic DNA. Translation: AAB05604.1 .
    PIRi S13289.
    T09448.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TJG X-ray 2.00 P 653-659 [» ]
    2B4C X-ray 3.30 G 82-483 [» ]
    2F5B X-ray 2.00 P 653-659 [» ]
    3TYG X-ray 3.25 A 251-272 [» ]
    A 341-386 [» ]
    4JM2 X-ray 3.10 E 88-483 [» ]
    ProteinModelPortali Q75760.
    SMRi Q75760. Positions 82-483, 503-656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59960N.
    IntActi Q75760. 3 interactions.
    MINTi MINT-8414778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q75760.

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms."
      Koyanagi Y., Miles S., Mitsuyasu R.T., Merrill J.E., Vinters H.V., Chen I.S.
      Science 236:819-822(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JRFLImported.
      Tissue: BrainImported.
    2. "HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain."
      O'Brien W.A., Koyanagi Y., Namazie A., Zhao J.Q., Diagne A., Idler K., Zack J.A., Chen I.S.
      Nature 348:69-73(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JRFLImported.
      Tissue: BrainImported.
    3. "HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease."
      Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S.
      J. Acquir. Immune Defic. Syndr. 4:1082-1092(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JRFLImported.
      Tissue: BrainImported.
    4. Pang S., Vinters H.V., Akashi T., O'Brien W.A., Chen I.S., Koyanagi Y., Namazie A., Zhao J., Diagne A., Idler K.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JRFLImported.
      Tissue: BrainImported.
    5. "Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope."
      Ofek G., Tang M., Sambor A., Katinger H., Mascola J.R., Wyatt R., Kwong P.D.
      J. Virol. 78:10724-10737(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 82-483.
    7. "Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications."
      Bryson S., Julien J.P., Hynes R.C., Pai E.F.
      J. Virol. 83:11862-11875(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 653-659.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 251-272 AND 341-386.
    9. "Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120."
      Kong L., Lee J.H., Doores K.J., Murin C.D., Julien J.P., McBride R., Liu Y., Marozsan A., Cupo A., Klasse P.J., Hoffenberg S., Caulfield M., King C.R., Hua Y., Le K.M., Khayat R., Deller M.C., Clayton T.
      , Tien H., Feizi T., Sanders R.W., Paulson J.C., Moore J.P., Stanfield R.L., Burton D.R., Ward A.B., Wilson I.A.
      Nat. Struct. Mol. Biol. 20:796-803(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 88-483.

    Entry informationi

    Entry nameiQ75760_9HIV1
    AccessioniPrimary (citable) accession number: Q75760
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3