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Q756Z0

- NTE1_ASHGO

UniProt

Q756Z0 - NTE1_ASHGO

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1252 – 12521By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi661 – 782122cNMP 1Add
    BLAST
    Nucleotide bindingi778 – 918141cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylcholine catabolic process Source: EnsemblFungi
    2. regulation of phospholipid biosynthetic process Source: EnsemblFungi

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:AER124W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome V

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15221522Lysophospholipase NTE1PRO_0000295308Add
    BLAST

    Proteomic databases

    PRIDEiQ756Z0.

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AER124W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ756Z0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7373LumenalBy similarityAdd
    BLAST
    Topological domaini95 – 15221428CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1219 – 1383165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1250 – 12545GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q756Z0-1 [UniParc]FASTAAdd to Basket

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    MVDGTYVNSS VEAISGEADT AAVAELANQM VMNFLYESSS WLAQSTGPFL     50
    WKGFRFLFLR LPSSLLVYLI NGTVPFYLVV LGSVFTPIIV YLILRSRVLS 100
    AYSRLKGDNE DEVIDKKKQL VNDSEAMLMG GPDGKRRSGF SSYLDEFLSA 150
    IKIFGYLDKL VFHELTKSMR TQRLEQGEVM LLDDSVGFAI VVEGGLHIYH 200
    KIAHSQGSTR ESMPLPEDRS FDSNEDDLTI NGERFQLLNK VKAGNPVSSL 250
    VSILKLFTDN HTPTVVDSSK SSPKQSAQVP IRQLISPFLD GNVERNKATL 300
    NMKQVPTAEY EIPSAERAGS NVSSFTQQLY ESMLPKDHAA EDVREPLPEI 350
    VAYAASDCAI AVIPASSFKR LMVKYPRSAS QIIQVILTKL YRVTFQTAHS 400
    YLGLTKEIMH TEVVLNNSTN FELPYYLQEA ILRKIKNGSK ESSVQESIHR 450
    ATLRSKNVHA HNSPTPNKIS RHIALESRDQ YNPGDLLSNV PLSRKGSKTA 500
    SSSSVSIPRI SSLRHQKEAA SSPLATLRRL EGNDSQNFAP LSSSSPMSVS 550
    EKPSVVGGGA HDNISQISFS SALEETEESS WRMALVESMF GYLGITNESI 600
    MPPTEDLLFL NNRASSGSSV CSVSSYSHPQ TINQDLFRCL SPELVRTKKK 650
    APRQKYTEEM PINVDFNTAK EEFAEGLETL FIPSGATIVE QNGNNKGLYY 700
    IVSGELLVCW KNEEDNIEYV LYTVKPGGIA GYLASLIGFK SFVSLRAKTD 750
    LYVGFLPIEV LERLCDKYFM IYLKIAETLT KLLSPKILKL DYALEWIHLE 800
    ASETLFNQND PANAIYVVLN GRLRQLHQKS KNEERLSRPT TQRKKRKDDN 850
    QPNVQVVGEY SQGCSFGEVE VLTAMNRVST VVAVRDTELA RIPRTLFEVL 900
    ALEHPSIMIR VSRLVAHKIL QRSSDIREPT KIVNSANGYR YDFNLTIPPS 950
    AGTSSWGNNS DGGSISYKTI TILPITYGLP VEEFANKLVS TFRQVGRSTI 1000
    GLTQCTTLKH LGRHAFDKLA NLKQSGYFAE LEELYELVVY IADTPVKSSW 1050
    TSTCISQGDC ILLLADASSD PEIGEFERLL INNRTTARTE LLLLHPERYV 1100
    EPGLTHKWLR KRTWVHQHHH MQFVSSQNPS ERVDSKAPPI PGAPPNLIGR 1150
    LKKRERLNQL TKRTQENFAR LLPDSIKLTV ENISMKYIQK KQKYYTPVSA 1200
    HKNDFLRLAR ILSGQAIGLV LGGGGARGIS HLGILKAIEE HGIPIDMIGG 1250
    TSIGSFVGGL YAKDYDLVPT YGRVKKFAGR IGSIWRMLSD LTWPVTSYTT 1300
    GHEFNRGIWK AFGDIRIEDF WIQYYCNSTN ITESMQEIHT FGYAWRYVRA 1350
    SMSLAGILPP ITDNGNMLLD GGYLDNLPVL EMKARGCKTI FAVDVGSVDD 1400
    RTPMDYGDSL NGFWIVLNRW NPFSKHPNVP SMAEIQMRLG YVASVNALEK 1450
    AKTTQGVVYF RPPIEDYATL DFAKFEEIYQ VGTAYGATFL HELEQNGKLP 1500
    RIPGNEPANG PGIHLLHRRN SI 1522
    Length:1,522
    Mass (Da):170,071
    Last modified:July 5, 2004 - v1
    Checksum:i9013C45B4D219D27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52807.1.
    RefSeqiNP_984983.1. NM_210337.1.

    Genome annotation databases

    EnsemblFungiiAAS52807; AAS52807; AGOS_AER124W.
    GeneIDi4621189.
    KEGGiago:AGOS_AER124W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52807.1 .
    RefSeqi NP_984983.1. NM_210337.1.

    3D structure databases

    ProteinModelPortali Q756Z0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AER124W.

    Proteomic databases

    PRIDEi Q756Z0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS52807 ; AAS52807 ; AGOS_AER124W .
    GeneIDi 4621189.
    KEGGi ago:AGOS_AER124W.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiNTE1_ASHGO
    AccessioniPrimary (citable) accession number: Q756Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3