Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q756Z0

- NTE1_ASHGO

UniProt

Q756Z0 - NTE1_ASHGO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1252 – 12521By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi661 – 782122cNMP 1Add
BLAST
Nucleotide bindingi778 – 918141cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylcholine catabolic process Source: EnsemblFungi
  2. regulation of phospholipid biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:AER124W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome V

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373LumenalBy similarityAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Topological domaini95 – 15221428CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15221522Lysophospholipase NTE1PRO_0000295308Add
BLAST

Proteomic databases

PRIDEiQ756Z0.

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AER124W.

Structurei

3D structure databases

ProteinModelPortaliQ756Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1219 – 1383165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1250 – 12545GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ756Z0.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q756Z0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDGTYVNSS VEAISGEADT AAVAELANQM VMNFLYESSS WLAQSTGPFL
60 70 80 90 100
WKGFRFLFLR LPSSLLVYLI NGTVPFYLVV LGSVFTPIIV YLILRSRVLS
110 120 130 140 150
AYSRLKGDNE DEVIDKKKQL VNDSEAMLMG GPDGKRRSGF SSYLDEFLSA
160 170 180 190 200
IKIFGYLDKL VFHELTKSMR TQRLEQGEVM LLDDSVGFAI VVEGGLHIYH
210 220 230 240 250
KIAHSQGSTR ESMPLPEDRS FDSNEDDLTI NGERFQLLNK VKAGNPVSSL
260 270 280 290 300
VSILKLFTDN HTPTVVDSSK SSPKQSAQVP IRQLISPFLD GNVERNKATL
310 320 330 340 350
NMKQVPTAEY EIPSAERAGS NVSSFTQQLY ESMLPKDHAA EDVREPLPEI
360 370 380 390 400
VAYAASDCAI AVIPASSFKR LMVKYPRSAS QIIQVILTKL YRVTFQTAHS
410 420 430 440 450
YLGLTKEIMH TEVVLNNSTN FELPYYLQEA ILRKIKNGSK ESSVQESIHR
460 470 480 490 500
ATLRSKNVHA HNSPTPNKIS RHIALESRDQ YNPGDLLSNV PLSRKGSKTA
510 520 530 540 550
SSSSVSIPRI SSLRHQKEAA SSPLATLRRL EGNDSQNFAP LSSSSPMSVS
560 570 580 590 600
EKPSVVGGGA HDNISQISFS SALEETEESS WRMALVESMF GYLGITNESI
610 620 630 640 650
MPPTEDLLFL NNRASSGSSV CSVSSYSHPQ TINQDLFRCL SPELVRTKKK
660 670 680 690 700
APRQKYTEEM PINVDFNTAK EEFAEGLETL FIPSGATIVE QNGNNKGLYY
710 720 730 740 750
IVSGELLVCW KNEEDNIEYV LYTVKPGGIA GYLASLIGFK SFVSLRAKTD
760 770 780 790 800
LYVGFLPIEV LERLCDKYFM IYLKIAETLT KLLSPKILKL DYALEWIHLE
810 820 830 840 850
ASETLFNQND PANAIYVVLN GRLRQLHQKS KNEERLSRPT TQRKKRKDDN
860 870 880 890 900
QPNVQVVGEY SQGCSFGEVE VLTAMNRVST VVAVRDTELA RIPRTLFEVL
910 920 930 940 950
ALEHPSIMIR VSRLVAHKIL QRSSDIREPT KIVNSANGYR YDFNLTIPPS
960 970 980 990 1000
AGTSSWGNNS DGGSISYKTI TILPITYGLP VEEFANKLVS TFRQVGRSTI
1010 1020 1030 1040 1050
GLTQCTTLKH LGRHAFDKLA NLKQSGYFAE LEELYELVVY IADTPVKSSW
1060 1070 1080 1090 1100
TSTCISQGDC ILLLADASSD PEIGEFERLL INNRTTARTE LLLLHPERYV
1110 1120 1130 1140 1150
EPGLTHKWLR KRTWVHQHHH MQFVSSQNPS ERVDSKAPPI PGAPPNLIGR
1160 1170 1180 1190 1200
LKKRERLNQL TKRTQENFAR LLPDSIKLTV ENISMKYIQK KQKYYTPVSA
1210 1220 1230 1240 1250
HKNDFLRLAR ILSGQAIGLV LGGGGARGIS HLGILKAIEE HGIPIDMIGG
1260 1270 1280 1290 1300
TSIGSFVGGL YAKDYDLVPT YGRVKKFAGR IGSIWRMLSD LTWPVTSYTT
1310 1320 1330 1340 1350
GHEFNRGIWK AFGDIRIEDF WIQYYCNSTN ITESMQEIHT FGYAWRYVRA
1360 1370 1380 1390 1400
SMSLAGILPP ITDNGNMLLD GGYLDNLPVL EMKARGCKTI FAVDVGSVDD
1410 1420 1430 1440 1450
RTPMDYGDSL NGFWIVLNRW NPFSKHPNVP SMAEIQMRLG YVASVNALEK
1460 1470 1480 1490 1500
AKTTQGVVYF RPPIEDYATL DFAKFEEIYQ VGTAYGATFL HELEQNGKLP
1510 1520
RIPGNEPANG PGIHLLHRRN SI
Length:1,522
Mass (Da):170,071
Last modified:July 5, 2004 - v1
Checksum:i9013C45B4D219D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52807.1.
RefSeqiNP_984983.1. NM_210337.1.

Genome annotation databases

EnsemblFungiiAAS52807; AAS52807; AGOS_AER124W.
GeneIDi4621189.
KEGGiago:AGOS_AER124W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA. Translation: AAS52807.1 .
RefSeqi NP_984983.1. NM_210337.1.

3D structure databases

ProteinModelPortali Q756Z0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AER124W.

Proteomic databases

PRIDEi Q756Z0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS52807 ; AAS52807 ; AGOS_AER124W .
GeneIDi 4621189.
KEGGi ago:AGOS_AER124W.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q756Z0.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiNTE1_ASHGO
AccessioniPrimary (citable) accession number: Q756Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3