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Q756Z0 (NTE1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:AER124W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length1522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15221522Lysophospholipase NTE1
PRO_0000295308

Regions

Topological domain1 – 7373Lumenal By similarity
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 15221428Cytoplasmic By similarity
Domain1219 – 1383165Patatin
Nucleotide binding661 – 782122cNMP 1
Nucleotide binding778 – 918141cNMP 2
Motif1250 – 12545GXSXG

Sites

Active site12521 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q756Z0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9013C45B4D219D27

FASTA1,522170,071
        10         20         30         40         50         60 
MVDGTYVNSS VEAISGEADT AAVAELANQM VMNFLYESSS WLAQSTGPFL WKGFRFLFLR 

        70         80         90        100        110        120 
LPSSLLVYLI NGTVPFYLVV LGSVFTPIIV YLILRSRVLS AYSRLKGDNE DEVIDKKKQL 

       130        140        150        160        170        180 
VNDSEAMLMG GPDGKRRSGF SSYLDEFLSA IKIFGYLDKL VFHELTKSMR TQRLEQGEVM 

       190        200        210        220        230        240 
LLDDSVGFAI VVEGGLHIYH KIAHSQGSTR ESMPLPEDRS FDSNEDDLTI NGERFQLLNK 

       250        260        270        280        290        300 
VKAGNPVSSL VSILKLFTDN HTPTVVDSSK SSPKQSAQVP IRQLISPFLD GNVERNKATL 

       310        320        330        340        350        360 
NMKQVPTAEY EIPSAERAGS NVSSFTQQLY ESMLPKDHAA EDVREPLPEI VAYAASDCAI 

       370        380        390        400        410        420 
AVIPASSFKR LMVKYPRSAS QIIQVILTKL YRVTFQTAHS YLGLTKEIMH TEVVLNNSTN 

       430        440        450        460        470        480 
FELPYYLQEA ILRKIKNGSK ESSVQESIHR ATLRSKNVHA HNSPTPNKIS RHIALESRDQ 

       490        500        510        520        530        540 
YNPGDLLSNV PLSRKGSKTA SSSSVSIPRI SSLRHQKEAA SSPLATLRRL EGNDSQNFAP 

       550        560        570        580        590        600 
LSSSSPMSVS EKPSVVGGGA HDNISQISFS SALEETEESS WRMALVESMF GYLGITNESI 

       610        620        630        640        650        660 
MPPTEDLLFL NNRASSGSSV CSVSSYSHPQ TINQDLFRCL SPELVRTKKK APRQKYTEEM 

       670        680        690        700        710        720 
PINVDFNTAK EEFAEGLETL FIPSGATIVE QNGNNKGLYY IVSGELLVCW KNEEDNIEYV 

       730        740        750        760        770        780 
LYTVKPGGIA GYLASLIGFK SFVSLRAKTD LYVGFLPIEV LERLCDKYFM IYLKIAETLT 

       790        800        810        820        830        840 
KLLSPKILKL DYALEWIHLE ASETLFNQND PANAIYVVLN GRLRQLHQKS KNEERLSRPT 

       850        860        870        880        890        900 
TQRKKRKDDN QPNVQVVGEY SQGCSFGEVE VLTAMNRVST VVAVRDTELA RIPRTLFEVL 

       910        920        930        940        950        960 
ALEHPSIMIR VSRLVAHKIL QRSSDIREPT KIVNSANGYR YDFNLTIPPS AGTSSWGNNS 

       970        980        990       1000       1010       1020 
DGGSISYKTI TILPITYGLP VEEFANKLVS TFRQVGRSTI GLTQCTTLKH LGRHAFDKLA 

      1030       1040       1050       1060       1070       1080 
NLKQSGYFAE LEELYELVVY IADTPVKSSW TSTCISQGDC ILLLADASSD PEIGEFERLL 

      1090       1100       1110       1120       1130       1140 
INNRTTARTE LLLLHPERYV EPGLTHKWLR KRTWVHQHHH MQFVSSQNPS ERVDSKAPPI 

      1150       1160       1170       1180       1190       1200 
PGAPPNLIGR LKKRERLNQL TKRTQENFAR LLPDSIKLTV ENISMKYIQK KQKYYTPVSA 

      1210       1220       1230       1240       1250       1260 
HKNDFLRLAR ILSGQAIGLV LGGGGARGIS HLGILKAIEE HGIPIDMIGG TSIGSFVGGL 

      1270       1280       1290       1300       1310       1320 
YAKDYDLVPT YGRVKKFAGR IGSIWRMLSD LTWPVTSYTT GHEFNRGIWK AFGDIRIEDF 

      1330       1340       1350       1360       1370       1380 
WIQYYCNSTN ITESMQEIHT FGYAWRYVRA SMSLAGILPP ITDNGNMLLD GGYLDNLPVL 

      1390       1400       1410       1420       1430       1440 
EMKARGCKTI FAVDVGSVDD RTPMDYGDSL NGFWIVLNRW NPFSKHPNVP SMAEIQMRLG 

      1450       1460       1470       1480       1490       1500 
YVASVNALEK AKTTQGVVYF RPPIEDYATL DFAKFEEIYQ VGTAYGATFL HELEQNGKLP 

      1510       1520 
RIPGNEPANG PGIHLLHRRN SI 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016818 Genomic DNA. Translation: AAS52807.1.
RefSeqNP_984983.1. NM_210337.1.

3D structure databases

ProteinModelPortalQ756Z0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_AER124W.

Proteomic databases

PRIDEQ756Z0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS52807; AAS52807; AGOS_AER124W.
GeneID4621189.
KEGGago:AGOS_AER124W.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.
PhylomeDBQ756Z0.

Family and domain databases

Gene3D2.60.120.10. 4 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ASHGO
AccessionPrimary (citable) accession number: Q756Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families