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Q756G9

- GCN5_ASHGO

UniProt

Q756G9 - GCN5_ASHGO

Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei186 – 1861Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. H3 histone acetyltransferase activity Source: EnsemblFungi

    GO - Biological processi

    1. positive regulation of transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
    2. regulation of transcription by chromatin organization Source: EnsemblFungi
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase GCN5 (EC:2.3.1.48)
    Gene namesi
    Name:GCN5
    Ordered Locus Names:AER297C
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome V

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: EnsemblFungi
    2. chromosome, centromeric region Source: EnsemblFungi
    3. SAGA complex Source: EnsemblFungi
    4. SLIK (SAGA-like) complex Source: EnsemblFungi

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Histone acetyltransferase GCN5PRO_0000211195Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AER297C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ756G9.
    SMRiQ756G9. Positions 112-275, 342-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 268156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST
    Domaini357 – 42771BromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000192257.
    KOiK06062.
    OMAiDNCRKYN.
    OrthoDBiEOG7XM37B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q756G9-1 [UniParc]FASTAAdd to Basket

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    MSMPLKRRNK QSQGNEPKKI KVEEQEAEEK ISEDIPVTDL KEPEALADIQ    50
    STSGGDEVSE GAQGDADPAE KSVGGLKEEV EDEEKGIVKF MFDGVEYKFR 100
    ERPSVIEEKE GKIEFRVVNN DNTRENMMVL TGLKNIFQKQ LPKMPKEYIA 150
    RLVYDRSHLS MAVIRKPLTV VGGITYRPFE KGEFAEIVFC AISSTEQVRG 200
    YGAHLMNHLK DYVRATTNIK YFLTYADNYA IGYFKKQGFT KEITLDKSVW 250
    MGYIKDYEGG TLMQCFMLPR IRYLDAAKIL LLQEAAIQRK IRTISRSHIV 300
    RPGLRQFEDL DNIEPIDPMS VPGLREAGWT PEMDELAQRP KRGPHYATMQ 350
    NVLTELQNHA AAWPFLQPVN RDEVPDYYEF IKEPMDLSTM EIKLENNRYE 400
    KMEDFIYDAR LIFNNCRAYN GENTSYFKYA NRLEKFFNTK MKEIPEYSHL 450
    LD 452
    Length:452
    Mass (Da):52,414
    Last modified:July 5, 2004 - v1
    Checksum:i9BA78D49039CAC66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52978.1.
    RefSeqiNP_985154.1. NM_210508.1.

    Genome annotation databases

    EnsemblFungiiAAS52978; AAS52978; AGOS_AER297C.
    GeneIDi4621367.
    KEGGiago:AGOS_AER297C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016818 Genomic DNA. Translation: AAS52978.1 .
    RefSeqi NP_985154.1. NM_210508.1.

    3D structure databases

    ProteinModelPortali Q756G9.
    SMRi Q756G9. Positions 112-275, 342-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AER297C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS52978 ; AAS52978 ; AGOS_AER297C .
    GeneIDi 4621367.
    KEGGi ago:AGOS_AER297C.

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000192257.
    KOi K06062.
    OMAi DNCRKYN.
    OrthoDBi EOG7XM37B.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiGCN5_ASHGO
    AccessioniPrimary (citable) accession number: Q756G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3