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Q756G9

- GCN5_ASHGO

UniProt

Q756G9 - GCN5_ASHGO

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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861Proton donor/acceptorBy similarity
Sitei186 – 1861Important for catalytic activityBy similarity

GO - Molecular functioni

  1. H3 histone acetyltransferase activity Source: EnsemblFungi

GO - Biological processi

  1. positive regulation of transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
  2. regulation of transcription by chromatin organization Source: EnsemblFungi
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:AER297C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome V

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: EnsemblFungi
  2. chromosome, centromeric region Source: EnsemblFungi
  3. SAGA complex Source: EnsemblFungi
  4. SLIK (SAGA-like) complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Histone acetyltransferase GCN5PRO_0000211195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AER297C.

Structurei

3D structure databases

ProteinModelPortaliQ756G9.
SMRiQ756G9. Positions 112-275, 342-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 268156N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini357 – 42771BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1923Acetyl-CoA bindingBy similarity
Regioni197 – 2037Acetyl-CoA bindingBy similarity
Regioni229 – 2324Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ756G9.
KOiK06062.
OMAiDNCRKYN.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q756G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMPLKRRNK QSQGNEPKKI KVEEQEAEEK ISEDIPVTDL KEPEALADIQ
60 70 80 90 100
STSGGDEVSE GAQGDADPAE KSVGGLKEEV EDEEKGIVKF MFDGVEYKFR
110 120 130 140 150
ERPSVIEEKE GKIEFRVVNN DNTRENMMVL TGLKNIFQKQ LPKMPKEYIA
160 170 180 190 200
RLVYDRSHLS MAVIRKPLTV VGGITYRPFE KGEFAEIVFC AISSTEQVRG
210 220 230 240 250
YGAHLMNHLK DYVRATTNIK YFLTYADNYA IGYFKKQGFT KEITLDKSVW
260 270 280 290 300
MGYIKDYEGG TLMQCFMLPR IRYLDAAKIL LLQEAAIQRK IRTISRSHIV
310 320 330 340 350
RPGLRQFEDL DNIEPIDPMS VPGLREAGWT PEMDELAQRP KRGPHYATMQ
360 370 380 390 400
NVLTELQNHA AAWPFLQPVN RDEVPDYYEF IKEPMDLSTM EIKLENNRYE
410 420 430 440 450
KMEDFIYDAR LIFNNCRAYN GENTSYFKYA NRLEKFFNTK MKEIPEYSHL

LD
Length:452
Mass (Da):52,414
Last modified:July 5, 2004 - v1
Checksum:i9BA78D49039CAC66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016818 Genomic DNA. Translation: AAS52978.1.
RefSeqiNP_985154.1. NM_210508.1.

Genome annotation databases

EnsemblFungiiAAS52978; AAS52978; AGOS_AER297C.
GeneIDi4621367.
KEGGiago:AGOS_AER297C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016818 Genomic DNA. Translation: AAS52978.1 .
RefSeqi NP_985154.1. NM_210508.1.

3D structure databases

ProteinModelPortali Q756G9.
SMRi Q756G9. Positions 112-275, 342-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AER297C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS52978 ; AAS52978 ; AGOS_AER297C .
GeneIDi 4621367.
KEGGi ago:AGOS_AER297C.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
InParanoidi Q756G9.
KOi K06062.
OMAi DNCRKYN.
OrthoDBi EOG7XM37B.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiGCN5_ASHGO
AccessioniPrimary (citable) accession number: Q756G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3