Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Proton donor/acceptorBy similarity1
Sitei186Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:AER297C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111951 – 452Histone acetyltransferase GCN5Add BLAST452

Proteomic databases

PRIDEiQ756G9

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS52978

Structurei

3D structure databases

ProteinModelPortaliQ756G9
SMRiQ756G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 268N-acetyltransferasePROSITE-ProRule annotationAdd BLAST156
Domaini357 – 427BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 192Acetyl-CoA bindingBy similarity3
Regioni197 – 203Acetyl-CoA bindingBy similarity7
Regioni229 – 232Acetyl-CoA bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000192257
InParanoidiQ756G9
KOiK06062
OMAiGTIMQCS
OrthoDBiEOG092C0SVC

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR037800 GCN5
IPR000182 GNAT_dom
PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q756G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMPLKRRNK QSQGNEPKKI KVEEQEAEEK ISEDIPVTDL KEPEALADIQ
60 70 80 90 100
STSGGDEVSE GAQGDADPAE KSVGGLKEEV EDEEKGIVKF MFDGVEYKFR
110 120 130 140 150
ERPSVIEEKE GKIEFRVVNN DNTRENMMVL TGLKNIFQKQ LPKMPKEYIA
160 170 180 190 200
RLVYDRSHLS MAVIRKPLTV VGGITYRPFE KGEFAEIVFC AISSTEQVRG
210 220 230 240 250
YGAHLMNHLK DYVRATTNIK YFLTYADNYA IGYFKKQGFT KEITLDKSVW
260 270 280 290 300
MGYIKDYEGG TLMQCFMLPR IRYLDAAKIL LLQEAAIQRK IRTISRSHIV
310 320 330 340 350
RPGLRQFEDL DNIEPIDPMS VPGLREAGWT PEMDELAQRP KRGPHYATMQ
360 370 380 390 400
NVLTELQNHA AAWPFLQPVN RDEVPDYYEF IKEPMDLSTM EIKLENNRYE
410 420 430 440 450
KMEDFIYDAR LIFNNCRAYN GENTSYFKYA NRLEKFFNTK MKEIPEYSHL

LD
Length:452
Mass (Da):52,414
Last modified:July 5, 2004 - v1
Checksum:i9BA78D49039CAC66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016818 Genomic DNA Translation: AAS52978.1
RefSeqiNP_985154.1, NM_210508.1

Genome annotation databases

EnsemblFungiiAAS52978; AAS52978; AGOS_AER297C
GeneIDi4621367
KEGGiago:AGOS_AER297C

Similar proteinsi

Entry informationi

Entry nameiGCN5_ASHGO
AccessioniPrimary (citable) accession number: Q756G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health