Reviewed, UniProtKB/Swiss-Prot Q756E2 (APT_ASHGO)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	APT1
Ordered Locus Names:	AER325W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Adenine phosphoribosyltransferase		PRO_0000227898
Regions
	Nucleotide binding	133 – 137	5	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q756E2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: ECCB97F1DF3DE7F1	FASTA	187	20,434
	10 20 30 40 50 60 MSINEYAKEL KAALAQYPNF PKEGVLFEDF LPIFRSPQLF QKLIDAFKMH LAEAFPETKI 70 80 90 100 110 120 DYLVGLESRG FLFGPSLALA IGAGFVPVRK AGKLPGQVVK TTYVKEYEED VFEMQVDSIP 130 140 150 160 170 180 VGATVVVVDD ILATGGSAGA AGDLIKQLGA TILEFIFVME LDFLKGREKL QAPVFTLLQG QEEALGN

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS53005.1.
RefSeq	NP_985181.1.
3D structure databases
SMR	Q756E2. Positions 1-178.
ModBase	Search...
Protein-protein interaction databases
STRING	Q756E2.
Genome annotation databases
GeneID	4621394.
GenomeReviews	Gene locus AER325W in contig AE016818_GR.
KEGG	ago:AGOS_AER325W.
NMPDR	fig|33169.1.peg.2826.
Organism-specific databases
AGD	AER325W.
Phylogenomic databases
eggNOG	fuNOG04141.
HOGENOM	HBG703830.
OMA	IRSIPDY.
OrthoDB	EOG9W3V4P.
Enzyme and pathway databases
BRENDA	2.4.2.7. 279361.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_ASHGO

Accession

Primary (citable) accession number: Q756E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)