Q756A9 (ACOX_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-coenzyme A oxidase
Short name=Acyl-CoA oxidase
EC=1.3.3.6

Gene names

Name:	POX1
Ordered Locus Names:	AER358C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 721	721	Acyl-coenzyme A oxidase		PRO_0000204691

Sequences

	Sequence		Length	Mass (Da)
	Q756A9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 3B83DB01956D3D8A	FASTA	721	80,285
	10 20 30 40 50 60 MTKASVVDQS APAYAPKRLL AEARAASKVN IEQVFAFLEG SPEKAALTNE LLAEFAADPA 70 80 90 100 110 120 ITQGPEYYDL TKAEQREQTV KKIARLALYL ENDIKLARKQ HHKDVVRDLQ SPDAPMVTMS 130 140 150 160 170 180 DMERFEKRST LVALIDPQLA TRLGVNLSLF GNAVRGNGTD EQIKYWLQER GLIFVKGIYG 190 200 210 220 230 240 CFAMTELGHG SNVANLQTRA TYDPASDSFV IQTPDLVATK WWIGGAAHSA THSTVYARLI 250 260 270 280 290 300 VEGKDYGVKV FVVPLRNPKT MELLAGISIG DIGSKMGRDG IDNGWIQFNN VRIPREYMLS 310 320 330 340 350 360 RFTKVIPGNP PKVEMEPLLD SISGYAALLS GRVSMVLDSY RFGARFSTIA TRYAFGRQQF 370 380 390 400 410 420 GDPTNETQLI EYPLHQFRVL PQLAIIYMMA PGAMKLMDTY NSCLGELYGA GDDKKKLTTV 430 440 450 460 470 480 SARMKDLFVE SASLKATCTW LTSTLIDELR QTCGGHGYSS YNGFGKAYND WVVQCTWEGD 490 500 510 520 530 540 NNVLCLTSGK SLLKKFAGIV RGKKVTICDT SMDYLRMDYI QKVVMGGTKK VSNLSTLPDY 550 560 570 580 590 600 YQIWSVILVK YLKRCAETVR DNNDPESVSK LLVSIAKFHA FYSMLQEFHR KLASDQSHVG 610 620 630 640 650 660 DAATKEVLWK VYKLSSLYFI DKFSGEFQQL KVMSPDQMTN VQEQMLAILP EIKTHAIRLT 670 680 690 700 710 720 DAFHLPDAVI NSSIGNYDGD IYHNYFNDVT RVAAKDKAPG VPPYADNACQ LSGLVTTSST I

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016818 Genomic DNA. Translation: AAS53038.1.
RefSeq	NP_985214.2. NM_210568.2.
3D structure databases
ProteinModelPortal	Q756A9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q756A9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4621430.
GenomeReviews	Gene locus AER358C in contig AE016818_GR.
KEGG	ago:AGOS_AER358C.
NMPDR	fig|33169.1.peg.2859.
Organism-specific databases
AGD	AER358C.
Phylogenomic databases
eggNOG	fuNOG06313.
HOGENOM	HBG737904.
OMA	MITIAIR.
OrthoDB	EOG4ZGSMP.
PhylomeDB	Q756A9.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
KO	K00232.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 2 hits.
ProtoNet	Search...

Entry information

Entry name

ACOX_ASHGO

Accession

Primary (citable) accession number: Q756A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program