Reviewed, UniProtKB/Swiss-Prot Q754U7 (MCES_ASHGO)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	ABD1
Ordered Locus Names:	AFL026W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	mRNA cap guanine-N7 methyltransferase		PRO_0000303900

Sequences

	Sequence		Length	Mass (Da)
	Q754U7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8FFCE1F2A42613DD	FASTA	430	50,419
	10 20 30 40 50 60 MALRPEKPVW MSQEQYDRQY GKLEEPKPPR EESKPGDQAK PSAEPKSGSE EKTEGSSSST 70 80 90 100 110 120 GQGEERPHFK IQKRRHQNYD LEERKKKQQL NKLREEQLKQ HDIEMAANKV VNVDQIVREH 130 140 150 160 170 180 YNERTFHAKR YNRNYSPIIK LRNFNNAIKY MLIDKYTRPR DVVLELGCGK GGDLRKYGAC 190 200 210 220 230 240 EISQFIGIDI SNESIREAQR RYLNMRDLDY QVILITGDCF GESLGVAVQP FPECRFPCDV 250 260 270 280 290 300 VSTQFCLHYA FETEEKARRA ILNVSKSLKV GGFFFGTIPD AEFIRYKLNK FSKEVERPSW 310 320 330 340 350 360 GNSIYKVVFA NNSYQLNDYE FETPYGNMYT YWLEDAIDNV PEYVIPFETL RNLCDEYGME 370 380 390 400 410 420 LEMQKPFNKF FVEEIPQWMN KFSPRLREGL QRSDGKYGVE GDEKEAASYF YTVFAFRKVK 430 DYVENAPAHA

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016819 Genomic DNA. Translation: AAS53346.1.
RefSeq	NP_985522.1.
3D structure databases
HSSP	HSSP built from PDB template 1RI5 based on UniProtKB Q8SR66.
SMR	Q754U7. Positions 138-420.
ModBase	Search...
Protein-protein interaction databases
STRING	Q754U7.
Genome annotation databases
GeneID	4621755.
GenomeReviews	Gene locus AFL026W in contig AE016819_GR.
KEGG	ago:AGOS_AFL026W.
NMPDR	fig|33169.1.peg.3167.
Organism-specific databases
AGD	AFL026W.
Phylogenomic databases
eggNOG	fuNOG05085.
HOGENOM	HBG377892.
OMA	WLEDAID.
OrthoDB	EOG9GMWD7.
Enzyme and pathway databases
BRENDA	2.1.1.56. 279361.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_ASHGO

Accession

Primary (citable) accession number: Q754U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)