Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q754U7 (MCES_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
mRNA cap guanine-N7 methyltransferase
EC=2.1.1.56
Alternative name(s):
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
Gene names
Name:ABD1
Ordered Locus Names:AFL026W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for methylating the 5'-cap structure of mRNAs By similarity.

Catalytic activity

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the methyltransferase superfamily. mRNA cap methyltransferase family.

Ontologies

Keywords
   Biological processmRNA capping
mRNA processing
   Cellular componentNucleus
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmRNA capping

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430mRNA cap guanine-N7 methyltransferase
PRO_0000303900

Sequences

Sequence LengthMass (Da)Tools
Q754U7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8FFCE1F2A42613DD

FASTA43050,419
        10         20         30         40         50         60 
MALRPEKPVW MSQEQYDRQY GKLEEPKPPR EESKPGDQAK PSAEPKSGSE EKTEGSSSST 

        70         80         90        100        110        120 
GQGEERPHFK IQKRRHQNYD LEERKKKQQL NKLREEQLKQ HDIEMAANKV VNVDQIVREH 

       130        140        150        160        170        180 
YNERTFHAKR YNRNYSPIIK LRNFNNAIKY MLIDKYTRPR DVVLELGCGK GGDLRKYGAC 

       190        200        210        220        230        240 
EISQFIGIDI SNESIREAQR RYLNMRDLDY QVILITGDCF GESLGVAVQP FPECRFPCDV 

       250        260        270        280        290        300 
VSTQFCLHYA FETEEKARRA ILNVSKSLKV GGFFFGTIPD AEFIRYKLNK FSKEVERPSW 

       310        320        330        340        350        360 
GNSIYKVVFA NNSYQLNDYE FETPYGNMYT YWLEDAIDNV PEYVIPFETL RNLCDEYGME 

       370        380        390        400        410        420 
LEMQKPFNKF FVEEIPQWMN KFSPRLREGL QRSDGKYGVE GDEKEAASYF YTVFAFRKVK 

       430 
DYVENAPAHA

« Hide

References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016819 Genomic DNA. Translation: AAS53346.1.
RefSeqNP_985522.1. NM_210876.1.

3D structure databases

HSSPHSSP built from PDB template 1RI5 based on UniProtKB Q8SR66.
ProteinModelPortalQ754U7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ754U7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4621755.
GenomeReviewsGene locus AFL026W in contig AE016819_GR.
KEGGago:AGOS_AFL026W.
NMPDRfig|33169.1.peg.3167.

Organism-specific databases

AGDAFL026W.

Phylogenomic databases

eggNOGfuNOG05085.
HOGENOMHBG377892.
OMAWLEDAID.
OrthoDBEOG4CZFR2.
PhylomeDBQ754U7.

Family and domain databases

InterProIPR016899. mRNA_G-N7_MeTrfase.
IPR004971. Pox_MCEL.
[Graphical view]
KOK00565.
PfamPF03291. Pox_MCEL. 1 hit.
[Graphical view]
PIRSFPIRSF028762. ABD1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCES_ASHGO
AccessionPrimary (citable) accession number: Q754U7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents