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Q754Q2

- ACH1_ASHGO

UniProt

Q754Q2 - ACH1_ASHGO

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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 30215-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei392 – 3921Coenzyme ABy similarity
Binding sitei396 – 3961Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetate CoA-transferase activity Source: EnsemblFungi
  2. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetate metabolic process Source: EnsemblFungi
  2. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:AFR020W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome VI

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. mitochondrion Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215516Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AFR020W.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 2815Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ754Q2.
KOiK01067.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q754Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVSQLLKQR VRYAPYLSKV RRAEELLPLF KHGQYIGWSG FTGVGAPKVI
60 70 80 90 100
PTALADHVEK NGLQGQLAFN LFVGASAGPE ENRWADLDMI LRRAPHQVGK
110 120 130 140 150
PIARAINDGR IKFFDKHLSM FPQDLTYGYY TRERTDGKIL DYAIVEATAI
160 170 180 190 200
KEDGSIVLGP SVGGSPEFMS AADKLIVEVN TATPSFEGLH DIDMPVLPPH
210 220 230 240 250
RVPYPYTRVD ERSGLDAVPV DPARVVALVE STERDKVGPN TPSDEGSRAI
260 270 280 290 300
AGHLVEFFEN EVRHGRLPAN LLPLQSGIGN IANAVIEGLA GASFRNLTVW
310 320 330 340 350
TEVLQDSFLD LFENGSLEFA TATSIRLTEA GFEKFFANWD EYSSKLCLRS
360 370 380 390 400
QVVSNSPEMI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF
410 420 430 440 450
LRNAKLSIMH APSARPSKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL
460 470 480 490 500
ADLRGLCPRE RAREIIRQCA HPDYKPILTD YLDRAEHYAQ RSRSMHEPHI
510 520
LQQALRFHTH LAEKGTMKVP SWD
Length:523
Mass (Da):57,808
Last modified:January 9, 2013 - v3
Checksum:iA768E4F08028CADA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016819 Genomic DNA. Translation: AAS53391.2.
RefSeqiNP_985567.2. NM_210921.2.

Genome annotation databases

GeneIDi4621806.
KEGGiago:AGOS_AFR020W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016819 Genomic DNA. Translation: AAS53391.2 .
RefSeqi NP_985567.2. NM_210921.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AFR020W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4621806.
KEGGi ago:AGOS_AFR020W.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
InParanoidi Q754Q2.
KOi K01067.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 437.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiACH1_ASHGO
AccessioniPrimary (citable) accession number: Q754Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3