Q754Q2 (ACH1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-CoA hydrolase
EC=3.1.2.1

Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	AFR020W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.
Sequence caution	The sequence AAS53391.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Acetyl-CoA hydrolase		PRO_0000215516

Sequences

	Sequence		Length	Mass (Da)
	Q754Q2 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: 2EE97CE91828D9A5	FASTA	523	57,820
	10 20 30 40 50 60 MTVSQLLKQR VRYAPYLSKV RRAEELLPLF KHGQYIGWSG FTGVGAPKVI PTALADHVEK 70 80 90 100 110 120 NGLQGQLAFN LFVGASAGPE ENRWADLDMI LRRAPHQVGK PIARAINDGR IKFFDKHLSM 130 140 150 160 170 180 FPQDLTYGYY TRERTDGKIL DYAIVEATAI KEDGSIVLGP SVGGSPEFMS AADKLIVEVN 190 200 210 220 230 240 TATPSFEGLH DIDMPVLPPH RVPYPYTRVD ERSGLDAVPV DPARVVALVE STERDKVGPN 250 260 270 280 290 300 TPSDEGSRAI AGHLVEFFEN EVRHGRLPAN LLPLQSGIGN IANAVIEGLA GASFRNLTVW 310 320 330 340 350 360 TEVLQDSFLD LFENGSLEFA TATSIRLTEA GFEKFFANWD EYSSKLCLRS QVVSNSPEMI 370 380 390 400 410 420 RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF LRNAKLSIMH APSARPSKTD 430 440 450 460 470 480 PTGISTIVPM ASHVDQLEHD LDVLVTDQGL ADLRGLCPRE RAREIIRQCA HPDYKPILTD 490 500 510 520 YLDRAEHYAQ RSRSMHEPHI LQQALRFHTH LAEKGTMKVP SWD

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016819 Genomic DNA. Translation: AAS53391.1. Different initiation.
RefSeq	NP_985567.2. NM_210921.2.
3D structure databases
ProteinModelPortal	Q754Q2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q754Q2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4621806.
GenomeReviews	Gene locus AFR020W in contig AE016819_GR.
KEGG	ago:AGOS_AFR020W.
NMPDR	fig|33169.1.peg.3212.
Organism-specific databases
AGD	AFR020W.
Phylogenomic databases
eggNOG	fuNOG04759.
HOGENOM	HBG289696.
OrthoDB	EOG4DBXNW.
PhylomeDB	Q754Q2.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. IPR017821. Succinate_CoA_transferase. [Graphical view]
KO	K01067.
PANTHER	PTHR21432. ActCoA_hydro. 1 hit. PTHR21432:SF10. PTHR21432:SF10. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_ASHGO

Accession

Primary (citable) accession number: Q754Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	December 14, 2011
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program