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Q754Q2

- ACH1_ASHGO

UniProt

Q754Q2 - ACH1_ASHGO

Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 3 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetate CoA-transferase activity Source: EnsemblFungi
    2. acetyl-CoA hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetate metabolic process Source: EnsemblFungi
    2. acetyl-CoA metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:ACH1
    Ordered Locus Names:AFR020W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome VI

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: EnsemblFungi
    2. mitochondrion Source: EnsemblFungi

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215516Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AFR020W.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    HOGENOMiHOG000172597.
    KOiK01067.
    OrthoDBiEOG7TQV8M.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q754Q2-1 [UniParc]FASTAAdd to Basket

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    MTVSQLLKQR VRYAPYLSKV RRAEELLPLF KHGQYIGWSG FTGVGAPKVI    50
    PTALADHVEK NGLQGQLAFN LFVGASAGPE ENRWADLDMI LRRAPHQVGK 100
    PIARAINDGR IKFFDKHLSM FPQDLTYGYY TRERTDGKIL DYAIVEATAI 150
    KEDGSIVLGP SVGGSPEFMS AADKLIVEVN TATPSFEGLH DIDMPVLPPH 200
    RVPYPYTRVD ERSGLDAVPV DPARVVALVE STERDKVGPN TPSDEGSRAI 250
    AGHLVEFFEN EVRHGRLPAN LLPLQSGIGN IANAVIEGLA GASFRNLTVW 300
    TEVLQDSFLD LFENGSLEFA TATSIRLTEA GFEKFFANWD EYSSKLCLRS 350
    QVVSNSPEMI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF 400
    LRNAKLSIMH APSARPSKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL 450
    ADLRGLCPRE RAREIIRQCA HPDYKPILTD YLDRAEHYAQ RSRSMHEPHI 500
    LQQALRFHTH LAEKGTMKVP SWD 523
    Length:523
    Mass (Da):57,808
    Last modified:January 9, 2013 - v3
    Checksum:iA768E4F08028CADA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016819 Genomic DNA. Translation: AAS53391.2.
    RefSeqiNP_985567.2. NM_210921.2.

    Genome annotation databases

    GeneIDi4621806.
    KEGGiago:AGOS_AFR020W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016819 Genomic DNA. Translation: AAS53391.2 .
    RefSeqi NP_985567.2. NM_210921.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AFR020W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4621806.
    KEGGi ago:AGOS_AFR020W.

    Phylogenomic databases

    eggNOGi COG0427.
    HOGENOMi HOG000172597.
    KOi K01067.
    OrthoDBi EOG7TQV8M.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 437.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiACH1_ASHGO
    AccessioniPrimary (citable) accession number: Q754Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 58 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3