Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3025-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei392Coenzyme ABy similarity1
Binding sitei396Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:AFR020W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155161 – 523Acetyl-CoA hydrolaseAdd BLAST523

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS53391

Structurei

3D structure databases

SMRiQ754Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 281Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597
InParanoidiQ754Q2
KOiK01067
OMAiDEALSWH
OrthoDBiEOG092C1EVJ

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Q754Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSQLLKQR VRYAPYLSKV RRAEELLPLF KHGQYIGWSG FTGVGAPKVI
60 70 80 90 100
PTALADHVEK NGLQGQLAFN LFVGASAGPE ENRWADLDMI LRRAPHQVGK
110 120 130 140 150
PIARAINDGR IKFFDKHLSM FPQDLTYGYY TRERTDGKIL DYAIVEATAI
160 170 180 190 200
KEDGSIVLGP SVGGSPEFMS AADKLIVEVN TATPSFEGLH DIDMPVLPPH
210 220 230 240 250
RVPYPYTRVD ERSGLDAVPV DPARVVALVE STERDKVGPN TPSDEGSRAI
260 270 280 290 300
AGHLVEFFEN EVRHGRLPAN LLPLQSGIGN IANAVIEGLA GASFRNLTVW
310 320 330 340 350
TEVLQDSFLD LFENGSLEFA TATSIRLTEA GFEKFFANWD EYSSKLCLRS
360 370 380 390 400
QVVSNSPEMI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF
410 420 430 440 450
LRNAKLSIMH APSARPSKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL
460 470 480 490 500
ADLRGLCPRE RAREIIRQCA HPDYKPILTD YLDRAEHYAQ RSRSMHEPHI
510 520
LQQALRFHTH LAEKGTMKVP SWD
Length:523
Mass (Da):57,808
Last modified:January 9, 2013 - v3
Checksum:iA768E4F08028CADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53391.2
RefSeqiNP_985567.2, NM_210921.2

Genome annotation databases

EnsemblFungiiAAS53391; AAS53391; AGOS_AFR020W
GeneIDi4621806
KEGGiago:AGOS_AFR020W

Similar proteinsi

Entry informationi

Entry nameiACH1_ASHGO
AccessioniPrimary (citable) accession number: Q754Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 9, 2013
Last modified: May 23, 2018
This is version 74 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health