Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q754Q2 (ACH1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA hydrolase

EC=3.1.2.1
Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase
Gene names
Name:ACH1
Ordered Locus Names:AFR020W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.

Catalytic activity

Acetyl-CoA + H2O = CoA + acetate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetate metabolic process

Inferred from electronic annotation. Source: EnsemblFungi

acetyl-CoA metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Inferred from electronic annotation. Source: EnsemblFungi

mitochondrion

Inferred from electronic annotation. Source: EnsemblFungi

   Molecular_functionacetate CoA-transferase activity

Inferred from electronic annotation. Source: EnsemblFungi

acetyl-CoA hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Acetyl-CoA hydrolase
PRO_0000215516

Sequences

Sequence LengthMass (Da)Tools
Q754Q2 [UniParc].

Last modified January 9, 2013. Version 3.
Checksum: A768E4F08028CADA

FASTA52357,808
        10         20         30         40         50         60 
MTVSQLLKQR VRYAPYLSKV RRAEELLPLF KHGQYIGWSG FTGVGAPKVI PTALADHVEK 

        70         80         90        100        110        120 
NGLQGQLAFN LFVGASAGPE ENRWADLDMI LRRAPHQVGK PIARAINDGR IKFFDKHLSM 

       130        140        150        160        170        180 
FPQDLTYGYY TRERTDGKIL DYAIVEATAI KEDGSIVLGP SVGGSPEFMS AADKLIVEVN 

       190        200        210        220        230        240 
TATPSFEGLH DIDMPVLPPH RVPYPYTRVD ERSGLDAVPV DPARVVALVE STERDKVGPN 

       250        260        270        280        290        300 
TPSDEGSRAI AGHLVEFFEN EVRHGRLPAN LLPLQSGIGN IANAVIEGLA GASFRNLTVW 

       310        320        330        340        350        360 
TEVLQDSFLD LFENGSLEFA TATSIRLTEA GFEKFFANWD EYSSKLCLRS QVVSNSPEMI 

       370        380        390        400        410        420 
RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF LRNAKLSIMH APSARPSKTD 

       430        440        450        460        470        480 
PTGISTIVPM ASHVDQTEHD LDVLVTDQGL ADLRGLCPRE RAREIIRQCA HPDYKPILTD 

       490        500        510        520 
YLDRAEHYAQ RSRSMHEPHI LQQALRFHTH LAEKGTMKVP SWD 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 437.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016819 Genomic DNA. Translation: AAS53391.2.
RefSeqNP_985567.2. NM_210921.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_AFR020W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4621806.
KEGGago:AGOS_AFR020W.

Phylogenomic databases

eggNOGCOG0427.
HOGENOMHOG000172597.
KOK01067.
OrthoDBEOG7TQV8M.

Family and domain databases

InterProIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACH1_ASHGO
AccessionPrimary (citable) accession number: Q754Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 9, 2013
Last modified: June 11, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families