Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-related protein 4

Gene

ARP4

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 4
Alternative name(s):
Actin-like protein ARP4
Short name:
Actin-like protein 4
Gene namesi
Name:ARP4
Ordered Locus Names:AFR105C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890911 – 479Actin-related protein 4Add BLAST479

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi33169.AAS53476

Structurei

3D structure databases

ProteinModelPortaliQ754G5
SMRiQ754G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP4 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000233340
InParanoidiQ754G5
KOiK11400
OMAiYAGDDFP
OrthoDBiEOG092C2OD2

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q754G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSALQVYG GDEITAVVID PGSFTTNIGY SGTDCPQAIL PSCYGKYTEG
60 70 80 90 100
EKDELFSEQS IGLPRKDYEI HNIVQNGEVV DWEKAEKQWD WAIRSELRFE
110 120 130 140 150
TNSGMPALLT EPIWNSEENR KKSLEVLLES MDFSACYLVP TATAVSFAMG
160 170 180 190 200
RPTCLVVDIG HDVTSVCPVV DGMTLSKSSM RSYIAGSLLN ELIRSQLAPR
210 220 230 240 250
KVIPLFQVAQ RRPVFMERKF DYEIHPSLQK FVNERQFFQE FKETMLQVAP
260 270 280 290 300
TSISKFKSEI ETTSKRSIEA PWGEELVYDS LQRLEFAEQL FTPDLSQFPE
310 320 330 340 350
DWPISKDGVV ETWHNDYVPL KRNKPGTNVK DKEGTLDATP VPDENSVTSA
360 370 380 390 400
DQPNDNGKRN LEETTPDQKN EVSGLADLIY SSIMSTDVDL RTTLSHNVVI
410 420 430 440 450
TGGTSSLPGL MDRISAELNR SLPALKFRML TSGQLRERQY QGWLGGSILA
460 470
SLGTFHQLWV GKQEYAEVGA DRLLKDRFR
Length:479
Mass (Da):53,866
Last modified:July 5, 2004 - v1
Checksum:iE8C10989B46DACFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53476.1
RefSeqiNP_985652.1, NM_211006.1

Genome annotation databases

EnsemblFungiiAAS53476; AAS53476; AGOS_AFR105C
GeneIDi4621895
KEGGiago:AGOS_AFR105C

Similar proteinsi

Entry informationi

Entry nameiARP4_ASHGO
AccessioniPrimary (citable) accession number: Q754G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health