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Q754E1 (Q754E1_ASHGO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:AGOS_AFR129W EMBL AAS53500.2
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding18 – 236NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding41 – 433NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding83 – 853NADP By similarity PIRSR PIRSR000109-3
Region137 – 1393Substrate binding By similarity PIRSR PIRSR000109-2
Region194 – 1952Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1911Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1981Proton donor By similarity PIRSR PIRSR000109-1
Binding site1111NADP By similarity PIRSR PIRSR000109-3
Binding site1111Substrate By similarity PIRSR PIRSR000109-2
Binding site1991Substrate By similarity PIRSR PIRSR000109-2
Binding site2681Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2951Substrate By similarity PIRSR PIRSR000109-2
Binding site4551Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4611Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q754E1 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: A76EF25BF4896461

FASTA49854,859
        10         20         30         40         50         60 
MRRDHILTAS RGDIGLIGLA VMGQNLILNA ADHGYTVVAY NRTVSKVDRF LEDEAKGKSI 

        70         80         90        100        110        120 
IGAHSVEELC ANLKRPRRVI LLVKAGSAVD AFIEQLLPYM EQGDIIIDGG NSHFPDSNRR 

       130        140        150        160        170        180 
FEELKQKGIH FVGSGVSGGE EGARYGPSLM PGGAPEAWPH IKEIFQSIAA KSEGEACCDW 

       190        200        210        220        230        240 
VGPAGAGHYV KMVHNGIEYG DMQLICEAYD IMKRLGGFTD KEIGQVFSEW NKGILDSFLI 

       250        260        270        280        290        300 
EITRDILLYE DLDGTPLVEK ILDSAGQKGT GKWTAINALD MGMPVTLIGE AVFARCLSSL 

       310        320        330        340        350        360 
KDERMRASAL LSGPEIPKDA VKDRKQFVDD LEQALYASKI MSYAQGFMLM REAGKTFGWE 

       370        380        390        400        410        420 
LNFPAIALMW RGGCIIRSVF LAQITKAYRE NPYLENLLFN KFFADAVTKA QQGWRRTIGL 

       430        440        450        460        470        480 
ATTYGIPTPA FSTALAFYDG YRSKRLPANL LQAQRDYFGA HTFRVLPEAA SAHLPVDKDI 

       490 
HINWTGKGGN ISASTYQA

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References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016819 Genomic DNA. Translation: AAS53500.2.
RefSeqNP_985676.2. NM_211030.2.

3D structure databases

ProteinModelPortalQ754E1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ754E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4621926.
GenomeReviewsGene locus AGOS_AFR129W in contig AE016819_GR.
KEGGago:AGOS_AFR129W.

Phylogenomic databases

OrthoDBEOG4VDT6Z.
PhylomeDBQ754E1.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ754E1_ASHGO
AccessionPrimary (citable) accession number: Q754E1
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: October 5, 2010
Last modified: December 14, 2011
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info