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Protein

Histone deacetylase

Gene

AGOS_AFR172C

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. NAD-independent histone deacetylase activity Source: EnsemblFungi

GO - Biological processi

  1. chromatin silencing at centromere Source: EnsemblFungi
  2. chromatin silencing at silent mating-type cassette Source: EnsemblFungi
  3. chromatin silencing at telomere Source: EnsemblFungi
  4. negative regulation of meiotic nuclear division Source: EnsemblFungi
  5. positive regulation of stress-activated MAPK cascade Source: EnsemblFungi
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:AGOS_AFR172CImported
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)Imported
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591 Componenti: Chromosome VI

Subcellular locationi

  1. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. Rpd3L-Expanded complex Source: EnsemblFungi
  3. Set3 complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AFR172C.

Structurei

3D structure databases

ProteinModelPortaliQ754A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ754A0.
KOiK11483.
OMAiDFGPTHP.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q754A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTFSYDAK TVNEQPLFEF GASYTPRVSY HYNSRVSQYH YGVRHPMKPF
60 70 80 90 100
RLMLTDHLVS RYGLHKVMDL YETRAATKEE VLAFHAQDYV DFLSHVAPEN
110 120 130 140 150
LNKLPRGSLE KFNIGDDCPI FQGLFEYSML YAGASLDASR KLINGQSEIA
160 170 180 190 200
INWSGGLHHA KKSNPSGFCY VNDIVLAILN LLRYHPRVLY IDIDLHHGDG
210 220 230 240 250
VQEAFYTTDR VFTVSFHKYN GEFFPGTGDL DEIGCSRGKH FSLNVPLNDG
260 270 280 290 300
IDDDSYINLF KSIIDPLVTS YKPTVIIQQC GADSLGHDRL GCFNLNIRAH
310 320 330 340 350
GECVKFVKSF GIPMLCVGGG GYTPRNVSRL WTYETGILND VLLPSDIPED
360 370 380 390 400
IPFREWFGPD YSLHPVLDDL YENKNSKKYL ENIRIRCLEN IKYLQGAPSV
410 420 430 440
RMDAELIPTQ DLPGLTEEEE DLIRELNQED DSYRLEQIEK DNVRRGELL
Length:449
Mass (Da):51,247
Last modified:July 5, 2004 - v1
Checksum:i122BA376FBA4129B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53543.1.
RefSeqiNP_985719.1. NM_211073.1.

Genome annotation databases

EnsemblFungiiAAS53543; AAS53543; AGOS_AFR172C.
GeneIDi4621976.
KEGGiago:AGOS_AFR172C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53543.1.
RefSeqiNP_985719.1. NM_211073.1.

3D structure databases

ProteinModelPortaliQ754A0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33169.AGOS_AFR172C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS53543; AAS53543; AGOS_AFR172C.
GeneIDi4621976.
KEGGiago:AGOS_AFR172C.

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ754A0.
KOiK11483.
OMAiDFGPTHP.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Pohlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056Imported.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056Imported.

Entry informationi

Entry nameiQ754A0_ASHGO
AccessioniPrimary (citable) accession number: Q754A0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.