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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi567Zinc; catalyticPROSITE-ProRule annotation1
Active sitei568PROSITE-ProRule annotation1
Metal bindingi571Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi574Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:AFR198W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000033856829 – 776Mitochondrial intermediate peptidaseAdd BLAST748

Proteomic databases

PRIDEiQ753X4

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS53569

Structurei

3D structure databases

ProteinModelPortaliQ753X4
SMRiQ753X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
InParanoidiQ753X4
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q753X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVRFYKRLD RQYIQSQRRW ILSSNKCLLQ GNKNATISPL RRAFDDQDHW
60 70 80 90 100
EESQAQNTSS EQDNKGKNSS YFWSRSKATA PQVAHTGLFQ NPYLNSPEGL
110 120 130 140 150
RKFANKSLTE ATALVRNLRE DSSQEGLVRY IIRLDQLSDI LCRVIDLCEF
160 170 180 190 200
LRAAHPDEQF VAAAQECHEQ MFEIMNILNT DVVLCKRLKQ VLSDENISSK
210 220 230 240 250
LSSEEIRVGH ILLEDFEKAG AYASPEVRKQ FIQLSQNISI IGQDFINNTE
260 270 280 290 300
SLSSSYIKIP CKDLESSGTS HLVLRQLTKD TMGNNYKIPT SGYAPYTLLN
310 320 330 340 350
ACPSEAIRRQ VWTAMFSCSE KQVKRLKSLL QLRRKLANIM GATDYVSYQL
360 370 380 390 400
EGKMAKSPEN VKNFLNTLVD HTKPLAAGEL EELAKLKRNV ENLSETNTLK
410 420 430 440 450
LMRPWDRDYY SSLSPNFTRP NHRVDGFTSI NTYFSLGVVM QGISDLFRDI
460 470 480 490 500
YGISLKPVVA QAGETWAPDV RKLQVISETE GIIGLIYCDL LERPGKTTSP
510 520 530 540 550
SHFTVCCSRQ IYPEENDFST IQVGENPDGS RFQMPVISLI CNFRATRHGK
560 570 580 590 600
NKSLCLLELS DVETLFHEMG HALHSMLGRT QLQNLSGTRC VTDFVELPSI
610 620 630 640 650
LMEHFAKDRR VLLRISSNYA TGEPIPEELL SAFQEQNNFL KNTETFSQIK
660 670 680 690 700
MSMLDQRLHS ITDQDDIIAV YHGLEREMEV LVDDQTNWCG RFGHLFGYGA
710 720 730 740 750
SYYSYLMDRA IAAKIWDHLF KKDPFSRSSG EKFKEGVLKW GGSRDAWQCI
760 770
ADALDEPRLV KGDDWAMRFI GEVEDM
Length:776
Mass (Da):88,597
Last modified:July 5, 2004 - v1
Checksum:i78E4201F03A2B72F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53569.1
RefSeqiNP_985745.1, NM_211099.1

Genome annotation databases

EnsemblFungiiAAS53569; AAS53569; AGOS_AFR198W
GeneIDi4622005
KEGGiago:AGOS_AFR198W

Similar proteinsi

Entry informationi

Entry nameiPMIP_ASHGO
AccessioniPrimary (citable) accession number: Q753X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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