Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q753X4

- PMIP_ASHGO

UniProt

Q753X4 - PMIP_ASHGO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
Active sitei568 – 5681PROSITE-ProRule annotation
Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi574 – 5741Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro

GO - Biological processi

  1. cellular iron ion homeostasis Source: EnsemblFungi
  2. protein processing involved in protein targeting to mitochondrion Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:AFR198W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome VI

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
BLAST
Chaini29 – 776748Mitochondrial intermediate peptidasePRO_0000338568Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AFR198W.

Structurei

3D structure databases

ProteinModelPortaliQ753X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiQ753X4.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q753X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVRFYKRLD RQYIQSQRRW ILSSNKCLLQ GNKNATISPL RRAFDDQDHW
60 70 80 90 100
EESQAQNTSS EQDNKGKNSS YFWSRSKATA PQVAHTGLFQ NPYLNSPEGL
110 120 130 140 150
RKFANKSLTE ATALVRNLRE DSSQEGLVRY IIRLDQLSDI LCRVIDLCEF
160 170 180 190 200
LRAAHPDEQF VAAAQECHEQ MFEIMNILNT DVVLCKRLKQ VLSDENISSK
210 220 230 240 250
LSSEEIRVGH ILLEDFEKAG AYASPEVRKQ FIQLSQNISI IGQDFINNTE
260 270 280 290 300
SLSSSYIKIP CKDLESSGTS HLVLRQLTKD TMGNNYKIPT SGYAPYTLLN
310 320 330 340 350
ACPSEAIRRQ VWTAMFSCSE KQVKRLKSLL QLRRKLANIM GATDYVSYQL
360 370 380 390 400
EGKMAKSPEN VKNFLNTLVD HTKPLAAGEL EELAKLKRNV ENLSETNTLK
410 420 430 440 450
LMRPWDRDYY SSLSPNFTRP NHRVDGFTSI NTYFSLGVVM QGISDLFRDI
460 470 480 490 500
YGISLKPVVA QAGETWAPDV RKLQVISETE GIIGLIYCDL LERPGKTTSP
510 520 530 540 550
SHFTVCCSRQ IYPEENDFST IQVGENPDGS RFQMPVISLI CNFRATRHGK
560 570 580 590 600
NKSLCLLELS DVETLFHEMG HALHSMLGRT QLQNLSGTRC VTDFVELPSI
610 620 630 640 650
LMEHFAKDRR VLLRISSNYA TGEPIPEELL SAFQEQNNFL KNTETFSQIK
660 670 680 690 700
MSMLDQRLHS ITDQDDIIAV YHGLEREMEV LVDDQTNWCG RFGHLFGYGA
710 720 730 740 750
SYYSYLMDRA IAAKIWDHLF KKDPFSRSSG EKFKEGVLKW GGSRDAWQCI
760 770
ADALDEPRLV KGDDWAMRFI GEVEDM
Length:776
Mass (Da):88,597
Last modified:July 5, 2004 - v1
Checksum:i78E4201F03A2B72F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53569.1.
RefSeqiNP_985745.1. NM_211099.1.

Genome annotation databases

EnsemblFungiiAAS53569; AAS53569; AGOS_AFR198W.
GeneIDi4622005.
KEGGiago:AGOS_AFR198W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53569.1 .
RefSeqi NP_985745.1. NM_211099.1.

3D structure databases

ProteinModelPortali Q753X4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AFR198W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS53569 ; AAS53569 ; AGOS_AFR198W .
GeneIDi 4622005.
KEGGi ago:AGOS_AFR198W.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi Q753X4.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiPMIP_ASHGO
AccessioniPrimary (citable) accession number: Q753X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3