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Q753T3 (Q753T3_ASHGO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
Ordered Locus Names:AFR243C
ORF Names:AGOS_AFR243C EMBL AAS53614.1
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site581Substrate By similarity PIRSR PIRSR001109-1
Binding site1341Substrate By similarity PIRSR PIRSR001109-1
Binding site1591Substrate By similarity PIRSR PIRSR001109-1
Binding site1891Substrate By similarity PIRSR PIRSR001109-1
Binding site1931Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
Q753T3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 77895FE24CA0623E

FASTA44949,094
        10         20         30         40         50         60 
MSIPAQNYKV ADLSLAAFGR KEIELSEHEM PGLMAIRKAY GDAQPLKGAR IAGCLHMTIQ 

        70         80         90        100        110        120 
TAVLIETLVA LGAEVTWTSC NIYSTQDHAA AAIAASGVPV FAWKGETEEE YLWCIEQQLF 

       130        140        150        160        170        180 
AFKDGKKLNL ILDDGGDLTT LVHEKYPEML DDCFGVSEET TTGVHHLYRM LKEGKLKVPA 

       190        200        210        220        230        240 
INVNDSVTKS KFDNLYGCRE SLVDGLKRAT DVMLAGKVAV VAGYGDVGKG CAAALRGMGA 

       250        260        270        280        290        300 
RVIVTEIDPI NALQAAMEGY QVTTMDQCAS YGQVFVTTTG CRDIIKKEHF LAMPEDAIVC 

       310        320        330        340        350        360 
NIGHFDIEID VAWLKANAVE AVNIKPQVDR YLLSSGRHVI LLADGRLVNL GCATGHSSFV 

       370        380        390        400        410        420 
MSCSFSNQVL AQIALFKAND EAFRQKYIEF QKTGPFDIGV HVLPKILDEA VAKFHLDKLG 

       430        440 
VKLTKLSSTQ SEYLGIPEEG PFKADHYRY

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References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016819 Genomic DNA. Translation: AAS53614.1.
RefSeqNP_985790.1. NM_211145.1.

3D structure databases

HSSPHSSP built from PDB template 1B3R based on UniProtKB P10760.
ProteinModelPortalQ753T3.
SMRQ753T3. Positions 8-449.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ753T3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4622053.
GenomeReviewsGene locus AFR243C in contig AE016819_GR.
KEGGago:AGOS_AFR243C.
NMPDRfig|33169.1.peg.3435.

Organism-specific databases

AGDAFR243C.

Phylogenomic databases

eggNOGfuNOG06806.
HOGENOMHBG352029.
OMASAQVWVT.
OrthoDBEOG41G6CK.
PhylomeDBQ753T3.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ753T3_ASHGO
AccessionPrimary (citable) accession number: Q753T3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info