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Protein

CTP-dependent diacylglycerol kinase 1

Gene

DGK1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus. Involved in pre-tRNA splicing (By similarity).By similarity

Catalytic activityi

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate.

Cofactori

Ca2+By similarity, Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

ER-Golgi transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
CTP-dependent diacylglycerol kinase 1 (EC:2.7.1.174)
Alternative name(s):
Diglyceride kinase 1
Short name:
DAG kinase 1
Gene namesi
Name:DGK1
Synonyms:HSD1
Ordered Locus Names:AFR329C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317CTP-dependent diacylglycerol kinase 1PRO_0000240381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the DGK1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000198978.
InParanoidiQ753I3.
KOiK16368.
OMAiFLVKHEI.
OrthoDBiEOG7VX96V.

Sequencei

Sequence statusi: Complete.

Q753I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEEELQTA ESAFVTGARR YSNDYSESES SSKHSGCSTP VEGTPAEAAT
60 70 80 90 100
TIGARASGGS TTWQRLRQLL MERGSDVHLP VTEIHLKSQE WFGDFITKHE
110 120 130 140 150
VPRKVFHSSI GFFTLALYVR DVDYRNVRLP LIVGFVHVLL LDVIRLHWPA
160 170 180 190 200
FNTLYCQVTG LLMRKKEVHT YNGVLWYLLG LIFAFSFFSK DVALVSLFLL
210 220 230 240 250
SWCDTAASTV GRLYGHLTPR ISRNKSLAGS LAAFVVGVIS CAVFYGYFVP
260 270 280 290 300
AYSHVNHPGE IMWNPETSRL SLVQLSLLGG FVASLSEGID LFNWDDNFTI
310
PVLSAIFMHT IIAFSQR
Length:317
Mass (Da):35,399
Last modified:July 5, 2004 - v1
Checksum:i9F9EC99A12DE022E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53700.1.
RefSeqiNP_985876.1. NM_211231.1.

Genome annotation databases

EnsemblFungiiAAS53700; AAS53700; AGOS_AFR329C.
GeneIDi4622141.
KEGGiago:AGOS_AFR329C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53700.1.
RefSeqiNP_985876.1. NM_211231.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS53700; AAS53700; AGOS_AFR329C.
GeneIDi4622141.
KEGGiago:AGOS_AFR329C.

Phylogenomic databases

HOGENOMiHOG000198978.
InParanoidiQ753I3.
KOiK16368.
OMAiFLVKHEI.
OrthoDBiEOG7VX96V.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiDGK1_ASHGO
AccessioniPrimary (citable) accession number: Q753I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: February 17, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.