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Protein

CTP-dependent diacylglycerol kinase 1

Gene

DGK1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus. Involved in pre-tRNA splicing (By similarity).By similarity

Catalytic activityi

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate.

Cofactori

Ca2+By similarity, Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processER-Golgi transport, Transport
LigandCalcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
CTP-dependent diacylglycerol kinase 1 (EC:2.7.1.174)
Alternative name(s):
Diglyceride kinase 1
Short name:
DAG kinase 1
Gene namesi
Name:DGK1
Synonyms:HSD1
Ordered Locus Names:AFR329C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002403811 – 317CTP-dependent diacylglycerol kinase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS53700

Family & Domainsi

Sequence similaritiesi

Belongs to the DGK1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000198978
InParanoidiQ753I3
KOiK16368
OMAiNWDDNFT
OrthoDBiEOG092C3R29

Family and domain databases

InterProiView protein in InterPro
IPR037997 Dgk1
PANTHERiPTHR31303 PTHR31303, 1 hit

Sequencei

Sequence statusi: Complete.

Q753I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEEELQTA ESAFVTGARR YSNDYSESES SSKHSGCSTP VEGTPAEAAT
60 70 80 90 100
TIGARASGGS TTWQRLRQLL MERGSDVHLP VTEIHLKSQE WFGDFITKHE
110 120 130 140 150
VPRKVFHSSI GFFTLALYVR DVDYRNVRLP LIVGFVHVLL LDVIRLHWPA
160 170 180 190 200
FNTLYCQVTG LLMRKKEVHT YNGVLWYLLG LIFAFSFFSK DVALVSLFLL
210 220 230 240 250
SWCDTAASTV GRLYGHLTPR ISRNKSLAGS LAAFVVGVIS CAVFYGYFVP
260 270 280 290 300
AYSHVNHPGE IMWNPETSRL SLVQLSLLGG FVASLSEGID LFNWDDNFTI
310
PVLSAIFMHT IIAFSQR
Length:317
Mass (Da):35,399
Last modified:July 5, 2004 - v1
Checksum:i9F9EC99A12DE022E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53700.1
RefSeqiNP_985876.1, NM_211231.1

Genome annotation databases

EnsemblFungiiAAS53700; AAS53700; AGOS_AFR329C
GeneIDi4622141
KEGGiago:AGOS_AFR329C

Similar proteinsi

Entry informationi

Entry nameiDGK1_ASHGO
AccessioniPrimary (citable) accession number: Q753I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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