Reviewed, UniProtKB/Swiss-Prot Q752Y3 (ALO_ASHGO)

Names and origin

Protein names

Recommended name:
    D-arabinono-1,4-lactone oxidase
      Short name=ALO
    EC=1.1.3.37
Alternative name(s):
    L-galactono-gamma-lactone oxidase

Gene names

Name:	ALO1
Ordered Locus Names:	AFR440C

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2).
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; D-erythroascorbic acid biosynthesis; D-erythro-ascorbic acid from D-arabinose: step 2/2.
Subcellular location	Mitochondrion membraneBy similarity. Note= Membrane-embedded By similarity.
Sequence similarities	Belongs to the oxygen-dependent FAD-linked oxidoreductase family. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-arabinono-1,4-lactone oxidase activity Inferred from electronic annotation. Source: InterPro FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	D-arabinono-1,4-lactone oxidase		PRO_0000128163
Regions
	Domain	25 – 199	175	FAD-binding PCMH-type
Amino acid modifications
	Modified residue	62	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q752Y3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8B975E346283331C	FASTA	532	59,965
	10 20 30 40 50 60 MSVLAGVEAS GIARNYVFKN WAGIYSARPR LYFQPRSEDE VVAIVRAARE QGRTIVTVGS 70 80 90 100 110 120 GHSPSDMCAT DDWMVNLDRL NGVLELQEDE QGRYADVTVA AGIRVYELHR YLSARGYALQ 130 140 150 160 170 180 NLGSISEQSV GGIISTGTHG SSPYHGLVSS QYVNLTLVNG RGELVFLDSE HEPEVFRAAM 190 200 210 220 230 240 LSLGKLGIIV RATIRVVPAF NIHSTQEVIN FETLLDNWET IWTSSEFIRC WWYPYVRKCV 250 260 270 280 290 300 LWRGVKTSEP AEKSRSSWWG TTLGRLVYES LLWLTVNVYP SLTPFVERFI FRQQYGKVET 310 320 330 340 350 360 FGNGDEAVQT SIDGLNMDCL FSQFVDEWAC PLNNGPEVLR SLDHSIAQAA QNKEFFVHVP 370 380 390 400 410 420 IEVRCSNTTL PHEYKCPEDR TVTAPGPVYG NLLRPYLDNT PSHLRYAPLS DVTNSQLTLY 430 440 450 460 470 480 INATIYRPFG TNTPIHKWFT LFEDTLGAAG GKPHWAKNFL GSTATAAGPV KSSDEYQDYE 490 500 510 520 530 MRGMATKIKE WYGDNLKQFQ KVRREQDPHN VFIANKDWAV KNGIIDIDEL DS

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016819 Genomic DNA. Translation: AAS53811.1.
RefSeq	NP_985987.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4622264.
KEGG	ago:AGOS_AFR440C.
NMPDR	fig|33169.1.peg.3632.
Organism-specific databases
AGD	AFR440C.
Phylogenomic databases
HOGENOM	Q752Y3.
Family and domain databases
InterPro	IPR007173. ALO. IPR010031. FAD_lactone_oxidase. IPR006094. Oxid_FAD_bind_N. IPR006093. Oxy_OxRdtase_FAD_BS. [Graphical view]
Pfam	PF04030. ALO. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view]
TIGRFAMs	TIGR01678. FAD_lactone_ox. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. PS00862. OX2_COVAL_FAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALO_ASHGO

Accession

Primary (citable) accession number: Q752Y3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)