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Q752Y3

- ALO_ASHGO

UniProt

Q752Y3 - ALO_ASHGO

Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. D-arabinono-1,4-lactone oxidase activity Source: UniProtKB-EC
    2. flavin adenine dinucleotide binding Source: InterPro
    3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. cellular response to oxidative stress Source: EnsemblFungi
    2. dehydro-D-arabinono-1,4-lactone biosynthetic process Source: EnsemblFungi

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00771; UER00766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
    Short name:
    ALO
    Alternative name(s):
    L-galactono-gamma-lactone oxidase
    Gene namesi
    Name:ALO1
    Ordered Locus Names:AFR440C
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome VI

    Subcellular locationi

    Mitochondrion membrane By similarity
    Note: Membrane-embedded.By similarity

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: EnsemblFungi

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532D-arabinono-1,4-lactone oxidasePRO_0000128163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621Pros-8alpha-FAD histidineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AFR440C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ752Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 199175FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0277.
    HOGENOMiHOG000204635.
    KOiK00107.
    OMAiMDCLFSQ.
    OrthoDBiEOG7JX3CZ.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view]
    PfamiPF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000136. LGO_GLO. 1 hit.
    SUPFAMiSSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q752Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVLAGVEAS GIARNYVFKN WAGIYSARPR LYFQPRSEDE VVAIVRAARE    50
    QGRTIVTVGS GHSPSDMCAT DDWMVNLDRL NGVLELQEDE QGRYADVTVA 100
    AGIRVYELHR YLSARGYALQ NLGSISEQSV GGIISTGTHG SSPYHGLVSS 150
    QYVNLTLVNG RGELVFLDSE HEPEVFRAAM LSLGKLGIIV RATIRVVPAF 200
    NIHSTQEVIN FETLLDNWET IWTSSEFIRC WWYPYVRKCV LWRGVKTSEP 250
    AEKSRSSWWG TTLGRLVYES LLWLTVNVYP SLTPFVERFI FRQQYGKVET 300
    FGNGDEAVQT SIDGLNMDCL FSQFVDEWAC PLNNGPEVLR SLDHSIAQAA 350
    QNKEFFVHVP IEVRCSNTTL PHEYKCPEDR TVTAPGPVYG NLLRPYLDNT 400
    PSHLRYAPLS DVTNSQLTLY INATIYRPFG TNTPIHKWFT LFEDTLGAAG 450
    GKPHWAKNFL GSTATAAGPV KSSDEYQDYE MRGMATKIKE WYGDNLKQFQ 500
    KVRREQDPHN VFIANKDWAV KNGIIDIDEL DS 532
    Length:532
    Mass (Da):59,965
    Last modified:July 5, 2004 - v1
    Checksum:i8B975E346283331C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016819 Genomic DNA. Translation: AAS53811.1.
    RefSeqiNP_985987.1. NM_211342.1.

    Genome annotation databases

    EnsemblFungiiAAS53811; AAS53811; AGOS_AFR440C.
    GeneIDi4622264.
    KEGGiago:AGOS_AFR440C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016819 Genomic DNA. Translation: AAS53811.1 .
    RefSeqi NP_985987.1. NM_211342.1.

    3D structure databases

    ProteinModelPortali Q752Y3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AFR440C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS53811 ; AAS53811 ; AGOS_AFR440C .
    GeneIDi 4622264.
    KEGGi ago:AGOS_AFR440C.

    Phylogenomic databases

    eggNOGi COG0277.
    HOGENOMi HOG000204635.
    KOi K00107.
    OMAi MDCLFSQ.
    OrthoDBi EOG7JX3CZ.

    Enzyme and pathway databases

    UniPathwayi UPA00771 ; UER00766 .

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view ]
    Pfami PF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000136. LGO_GLO. 1 hit.
    SUPFAMi SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiALO_ASHGO
    AccessioniPrimary (citable) accession number: Q752Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3