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Q752X9 (FDFT_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Squalene synthase
Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:ERG9
Ordered Locus Names:AFR444C
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium ›

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol By similarity.

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Squalene synthase
PRO_0000067446

Regions

Transmembrane293 – 31321Helical; Potential
Transmembrane420 – 44021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q752X9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 53807044FB95195B

FASTA44150,873
        10         20         30         40         50         60 
MGKVVQLFTH PLELKAALKL KFLREPLYPA DDTQGSAELK RCYQLLQRTS RSFAAVIMEL 

        70         80         90        100        110        120 
HPELRNAVML FYLILRALDT VEDDMTISPK VKVPLLREFD QKLKLDTWSF DGNAKTEKDR 

       130        140        150        160        170        180 
DVLVEFSTIL AEFHKLKPEY QQVIADITHK MGNGMADYIL DEKFNLSGLE TIQDYDRYCH 

       190        200        210        220        230        240 
YVAGLVGDGL THLIMLAKFS SPGLYYDSPD LYESMGLFLQ KTNIIRDYAE DLADGRSFWP 

       250        260        270        280        290        300 
KEIWSHYADD LASFSKPENA TAGVYCINHL VLNALGHVQH VLTYLASLRE QSSFQFCAIP 

       310        320        330        340        350        360 
QVMAIATLAL VFGNERVLQT SVKIRKGTTC YLILKSRTFQ GCVEIFEHYL RDIRKRLTVA 

       370        380        390        400        410        420 
DPNYLKLNIE IAKLDKFIEE MYQDKLPVGA KPQETEIYKK VRERSAYDLE VLPREQEEEF 

       430        440 
KFNVLLSILF TVFGALYWYA K

« Hide

References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016819 Genomic DNA. Translation: AAS53815.1.
RefSeqNP_985991.1. NM_211346.1.

3D structure databases

ProteinModelPortalQ752X9.
ModBaseSearch...

Protein-protein interaction databases

STRING33169.AGOS_AFR444C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS53815; AAS53815; AGOS_AFR444C.
GeneID4622268.
KEGGago:AGOS_AFR444C.

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000186940.
KOK00801.
OMAELRHAVC.
OrthoDBEOG4BP4MQ.
PhylomeDBQ752X9.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_ASHGO
AccessionPrimary (citable) accession number: Q752X9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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