Reviewed,
UniProtKB/Swiss-Prot Q752X9 (FDFT_ASHGO)
Last modified
February 9, 2010.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Squalene synthetase Short name=SQS Short name=SS EC=2.5.1.21 Alternative name(s): Farnesyl-diphosphate farnesyltransferase FPP:FPP farnesyltransferase | ||||
| Gene names |
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| Organism | Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome] | ||||
| Taxonomic identifier | 33169 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium |
Protein attributes
| Sequence length | 441 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)+. |
| Cofactor | Magnesium. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the phytoene/squalene synthetase family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016819 Genomic DNA. Translation: AAS53815.1. |
| RefSeq | NP_985991.1. |
3D structure databases | |
| SMR | Q752X9. Positions 38-374. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q752X9. |
Genome annotation databases | |
| GeneID | 4622268. |
| GenomeReviews | Gene locus AFR444C in contig AE016819_GR. |
| KEGG | ago:AGOS_AFR444C. |
| NMPDR | fig|33169.1.peg.3636. |
Organism-specific databases | |
| AGD | AFR444C. |
Phylogenomic databases | |
| eggNOG | fuNOG05680. |
| HOGENOM | HBG600510. |
| OMA | RSFWPKE. |
| OrthoDB | EOG9BZPJW. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.21. 279361. |
Family and domain databases | |
| InterPro | IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth. IPR019845. Squalene/phytoene_synthase_CS. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| Pfam | PF00494. SQS_PSY. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01559. squal_synth. 1 hit. |
| PROSITE | PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FDFT_ASHGO | ||||||||
| Accession | Primary (citable) accession number: Q752X9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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