Q752Q3 (EPL1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enhancer of polycomb-like protein 1

Gene names

Name:	EPL1
Ordered Locus Names:	AFR520W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	742 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M By similarity.
Subunit structure	Component of the NuA4 histone acetyltransferase complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the enhancer of polycomb family.

Ontologies

Keywords
Biological process	Cell cycle DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: EnsemblFungi transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Piccolo NuA4 histone acetyltransferase complex Inferred from electronic annotation. Source: EnsemblFungi
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EnsemblFungi
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 742	742	Enhancer of polycomb-like protein 1		PRO_0000214155
Regions
	Compositional bias	417 – 446	30	Gln-rich
	Compositional bias	711 – 741	31	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q752Q3 [UniParc]. Last modified January 9, 2013. Version 2. Checksum: 8B8F248919375E70	FASTA	742	86,365
	10 20 30 40 50 60 MPTPSAQLDQ GIISSNGGTS GVSASSTRFR HRKISVKQKL RVYKASDLKD LDQDELQQRE 70 80 90 100 110 120 LQEIETGVEK NEEREVHLHK ILQKNQLQLQ DLYIPTPDAS RVWKEFDEMY QGRFTTPASY 130 140 150 160 170 180 IQFSVQLEDC CGPAYNMDER DEAYLAELNG GESEALTEDE FELLMTNFES AIRERQPFLA 190 200 210 220 230 240 MDPESLLMYE DLKPTMLKND IGDAGLKTEL AAELQLGDQP FVTKFDSPAT LRTRNMVELI 250 260 270 280 290 300 EKYGAEVYEY WKKRKVEVAG GSIIPSLKAE RSTDKDDNDP YFCFRRREVR QTRKTRRVDT 310 320 330 340 350 360 QNSQKLRLLY QQLQYTKELA LLVAKREKMS MDMLLRDREI FQLRCDIKTV KRGLGIKGED 370 380 390 400 410 420 ELLISQKRRK LVSNVITNKK YVSTQADAAA LRRLRVAKVK DKKLLSKQLS STDLKRQQSQ 430 440 450 460 470 480 LQKLDQQQRQ QQQQQQPQIN GAQCQQDGSG VSHVYVKLPT SKIPDIVLED VDKVLSMKER 490 500 510 520 530 540 NTKRFVEEKM KKRREEDGDI FFNLTDDPYN PVFEITIPQN ISPTNAPFSS IVSSNFEISR 550 560 570 580 590 600 SYYTPNLQNC ITGNTNSVLA YNKEGEIVES QKYKKIEFYS PFEEKNDSHT REIPVRFRRR 610 620 630 640 650 660 LGRYGVEYID RKDVSRNPSD LLGEFMDFSL IAEQEQSSDA VNVYDSQLDE LFRLHDKWKY 670 680 690 700 710 720 DSDHNAYGIK FSDEPSRLNQ ISNETQVIRF GTMLGTKSYE QLREATLKYR QNVMAQRKKL 730 740 VNAQRQQQQQ QQEQQEQEHQ QA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	Dietrich F.S., Voegeli S., Philippsen P. Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 353.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016819 Genomic DNA. Translation: AAS53891.2.
RefSeq	NP_986067.2. NM_212203.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_AFR520W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4622346.
KEGG	ago:AGOS_AFR520W.
Phylogenomic databases
eggNOG	NOG304124.
HOGENOM	HOG000094341.
KO	K11322.
OMA	FRQRKIS.
OrthoDB	EOG45TGWG.
Family and domain databases
InterPro	IPR024943. Enhancer_polycomb. IPR019542. Enhancer_polycomb-like_N. [Graphical view]
PANTHER	PTHR14898. PTHR14898. 1 hit.
Pfam	PF10513. EPL1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPL1_ASHGO

Accession

Primary (citable) accession number: Q752Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program