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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179By similarity1
Active sitei381By similarity1
Active sitei445By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiashgo-q752m5. Carboxypeptidase_S10.
MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:AFR549W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 512LumenalSequence analysisAdd BLAST493
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 599CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041190120 – 599Pheromone-processing carboxypeptidase KEX1Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi442N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ752M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
InParanoidiQ752M5.
KOiK01288.
OMAiQECENIL.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q752M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVRKLTLIG AALARAALAL QQEDFVVNGE LLPGVREIDR AEVPEMHAGL
60 70 80 90 100
MPLEEDEDGR ALFFWRMGEQ CGKRCSNELI VWLNGGPGCS SMDGALMETG
110 120 130 140 150
AFRVAEDGKL YLNSGSWHTR GTMLFVDQPV GTGFSRPGRD GRLRTELSQL
160 170 180 190 200
ADDFLLFMER YYAVFPEDRR RTLVLAGESY AGQYLPYFAD AVVRRNAERA
210 220 230 240 250
PEERYKLQNV MIGNGWVDPD LQSLSYVPFV SSRGLFGPET RNFQDILRDQ
260 270 280 290 300
EACQNAINHG PAKGFSHPEC EGILPKLLSS IPGPDRPVQQ CINMYDIRLR
310 320 330 340 350
DVFPSCGMNW PADLPNVHKF FGTPGVLEAL HVDPQVAGPW VECKSAVSEA
360 370 380 390 400
LVNAHSRPSV HLIPGLIEAG VKFVFFNGDQ DVICNNMGVE MLIAELRWRG
410 420 430 440 450
HMGFSNATEN FDWYHSDADA KTLVAAGVVK RDGPVTFISV FNASHMVPFD
460 470 480 490 500
VPRISRGIID IERSATILGV KGDSRMLITV DTEEDVTLST NAERNQQIRH
510 520 530 540 550
NQLKRLNGDT RKFTIAVFGL TISSIIGVIV YFSMRLHYGA KIRAILTNPK
560 570 580 590
SGTSSADDFS MDDEYTGTVM GDFHHGTHKK GQYYAVPDTD ISSSELHSV
Length:599
Mass (Da):66,497
Last modified:July 5, 2004 - v1
Checksum:i64D09A52E115AF6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53920.1.
RefSeqiNP_986096.1. NM_212232.1.

Genome annotation databases

EnsemblFungiiAAS53920; AAS53920; AGOS_AFR549W.
GeneIDi4622376.
KEGGiago:AGOS_AFR549W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53920.1.
RefSeqiNP_986096.1. NM_212232.1.

3D structure databases

ProteinModelPortaliQ752M5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiashgo-q752m5. Carboxypeptidase_S10.
MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS53920; AAS53920; AGOS_AFR549W.
GeneIDi4622376.
KEGGiago:AGOS_AFR549W.

Phylogenomic databases

HOGENOMiHOG000208879.
InParanoidiQ752M5.
KOiK01288.
OMAiQECENIL.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_ASHGO
AccessioniPrimary (citable) accession number: Q752M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.