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Q752M5 (KEX1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:AFR549W
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 599580Pheromone-processing carboxypeptidase KEX1
PRO_0000411901

Regions

Topological domain20 – 512493Lumenal Potential
Transmembrane513 – 53321Helical; Potential
Topological domain534 – 59966Cytoplasmic Potential

Sites

Active site1791 By similarity
Active site3811 By similarity
Active site4451 By similarity

Amino acid modifications

Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q752M5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 64D09A52E115AF6B

FASTA59966,497
        10         20         30         40         50         60 
MLVRKLTLIG AALARAALAL QQEDFVVNGE LLPGVREIDR AEVPEMHAGL MPLEEDEDGR 

        70         80         90        100        110        120 
ALFFWRMGEQ CGKRCSNELI VWLNGGPGCS SMDGALMETG AFRVAEDGKL YLNSGSWHTR 

       130        140        150        160        170        180 
GTMLFVDQPV GTGFSRPGRD GRLRTELSQL ADDFLLFMER YYAVFPEDRR RTLVLAGESY 

       190        200        210        220        230        240 
AGQYLPYFAD AVVRRNAERA PEERYKLQNV MIGNGWVDPD LQSLSYVPFV SSRGLFGPET 

       250        260        270        280        290        300 
RNFQDILRDQ EACQNAINHG PAKGFSHPEC EGILPKLLSS IPGPDRPVQQ CINMYDIRLR 

       310        320        330        340        350        360 
DVFPSCGMNW PADLPNVHKF FGTPGVLEAL HVDPQVAGPW VECKSAVSEA LVNAHSRPSV 

       370        380        390        400        410        420 
HLIPGLIEAG VKFVFFNGDQ DVICNNMGVE MLIAELRWRG HMGFSNATEN FDWYHSDADA 

       430        440        450        460        470        480 
KTLVAAGVVK RDGPVTFISV FNASHMVPFD VPRISRGIID IERSATILGV KGDSRMLITV 

       490        500        510        520        530        540 
DTEEDVTLST NAERNQQIRH NQLKRLNGDT RKFTIAVFGL TISSIIGVIV YFSMRLHYGA 

       550        560        570        580        590 
KIRAILTNPK SGTSSADDFS MDDEYTGTVM GDFHHGTHKK GQYYAVPDTD ISSSELHSV 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016819 Genomic DNA. Translation: AAS53920.1.
RefSeqNP_986096.1. NM_212232.1.

3D structure databases

ProteinModelPortalQ752M5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_AFR549W.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS53920; AAS53920; AGOS_AFR549W.
GeneID4622376.
KEGGago:AGOS_AFR549W.

Phylogenomic databases

HOGENOMHOG000208879.
KOK01288.
OMASCKEAIN.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ASHGO
AccessionPrimary (citable) accession number: Q752M5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries