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Protein

Protein transport protein SEC61 subunit alpha

Gene

SEC61

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC61 subunit alpha
Gene namesi
Name:SEC61
Ordered Locus Names:AFR596W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 75LumenalSequence analysisAdd BLAST22
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 118CytoplasmicSequence analysisAdd BLAST22
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 145LumenalSequence analysis6
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 245CytoplasmicSequence analysisAdd BLAST79
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 362LumenalSequence analysisAdd BLAST96
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 416CytoplasmicSequence analysisAdd BLAST33
Transmembranei417 – 435HelicalSequence analysisAdd BLAST19
Topological domaini436 – 441LumenalSequence analysis6
Transmembranei442 – 459HelicalSequence analysisAdd BLAST18
Topological domaini460 – 480CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317801 – 480Protein transport protein SEC61 subunit alphaAdd BLAST480

Proteomic databases

PRIDEiQ752H7

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

STRINGi33169.AAS53967

Structurei

3D structure databases

ProteinModelPortaliQ752H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231249
InParanoidiQ752H7
KOiK10956
OMAiKWGIGSG
OrthoDBiEOG092C21L2

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
InterProiView protein in InterPro
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
IPR019561 Translocon_Sec61/SecY_plug_dom
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF10559 Plug_translocon, 1 hit
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q752H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRLLDLFK PFEAFLPEVI APERKVPYNQ KLIWTAVSLL IFLVLGQIPL
60 70 80 90 100
YGIVSSEGSD PLQWLRAMLA SNRGTLMELG VSPIITSSMI FQFLQGTQLL
110 120 130 140 150
QVNLESKQDR ELFQIAQKVC AIVLTLGQAI VVVLTGNYGS VSNLGIAISL
160 170 180 190 200
LLILQLVFAS FIVLLLDELL IKGYGLGSGI SLFTATNIAE QIFWKAFAPT
210 220 230 240 250
TVNNGRGTEF EGAVVALFHL LSVRKDKKRA LVEAFYRDYL PNMFQVLSTV
260 270 280 290 300
FVFLFVLYLQ GFRYELPVRS TRTRGQVGSY PIKLFYTSNT PIMLQSALTS
310 320 330 340 350
NIFLTSQLLY QKFPNNPIVK MLGVWGTRSD APYSPNAAIS GLSYYIQPPF
360 370 380 390 400
SFTEALLDPI KTVVYVTFVL GACAMFSRTW IDVSGTSPRD VSKQFKEQGL
410 420 430 440 450
VINGRRETSV YRELKKVIPT AAAFGGATIG ALSVGSDLLG TLGSGTSILM
460 470 480
ATTTIYGYYE TAAKEGGFAK NLVAGFSEML
Length:480
Mass (Da):52,732
Last modified:July 5, 2004 - v1
Checksum:iAA8B53EF4E07BF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA Translation: AAS53967.1
RefSeqiNP_986143.1, NM_212279.1

Genome annotation databases

EnsemblFungiiAAS53967; AAS53967; AGOS_AFR596W
GeneIDi4622426
KEGGiago:AGOS_AFR596W

Similar proteinsi

Entry informationi

Entry nameiSC61A_ASHGO
AccessioniPrimary (citable) accession number: Q752H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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