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Protein

Protein transport protein SEC61 subunit alpha

Gene

SEC61

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC61 subunit alpha
Gene namesi
Name:SEC61
Ordered Locus Names:AFR596W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 75LumenalSequence analysisAdd BLAST22
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 118CytoplasmicSequence analysisAdd BLAST22
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 145LumenalSequence analysis6
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 245CytoplasmicSequence analysisAdd BLAST79
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 362LumenalSequence analysisAdd BLAST96
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 416CytoplasmicSequence analysisAdd BLAST33
Transmembranei417 – 435HelicalSequence analysisAdd BLAST19
Topological domaini436 – 441LumenalSequence analysis6
Transmembranei442 – 459HelicalSequence analysisAdd BLAST18
Topological domaini460 – 480CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317801 – 480Protein transport protein SEC61 subunit alphaAdd BLAST480

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ752H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiQ752H7.
KOiK10956.
OMAiWKAFAPT.
OrthoDBiEOG092C21L2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q752H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRLLDLFK PFEAFLPEVI APERKVPYNQ KLIWTAVSLL IFLVLGQIPL
60 70 80 90 100
YGIVSSEGSD PLQWLRAMLA SNRGTLMELG VSPIITSSMI FQFLQGTQLL
110 120 130 140 150
QVNLESKQDR ELFQIAQKVC AIVLTLGQAI VVVLTGNYGS VSNLGIAISL
160 170 180 190 200
LLILQLVFAS FIVLLLDELL IKGYGLGSGI SLFTATNIAE QIFWKAFAPT
210 220 230 240 250
TVNNGRGTEF EGAVVALFHL LSVRKDKKRA LVEAFYRDYL PNMFQVLSTV
260 270 280 290 300
FVFLFVLYLQ GFRYELPVRS TRTRGQVGSY PIKLFYTSNT PIMLQSALTS
310 320 330 340 350
NIFLTSQLLY QKFPNNPIVK MLGVWGTRSD APYSPNAAIS GLSYYIQPPF
360 370 380 390 400
SFTEALLDPI KTVVYVTFVL GACAMFSRTW IDVSGTSPRD VSKQFKEQGL
410 420 430 440 450
VINGRRETSV YRELKKVIPT AAAFGGATIG ALSVGSDLLG TLGSGTSILM
460 470 480
ATTTIYGYYE TAAKEGGFAK NLVAGFSEML
Length:480
Mass (Da):52,732
Last modified:July 5, 2004 - v1
Checksum:iAA8B53EF4E07BF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53967.1.
RefSeqiNP_986143.1. NM_212279.1.

Genome annotation databases

EnsemblFungiiAAS53967; AAS53967; AGOS_AFR596W.
GeneIDi4622426.
KEGGiago:AGOS_AFR596W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS53967.1.
RefSeqiNP_986143.1. NM_212279.1.

3D structure databases

ProteinModelPortaliQ752H7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS53967; AAS53967; AGOS_AFR596W.
GeneIDi4622426.
KEGGiago:AGOS_AFR596W.

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiQ752H7.
KOiK10956.
OMAiWKAFAPT.
OrthoDBiEOG092C21L2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC61A_ASHGO
AccessioniPrimary (citable) accession number: Q752H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.