Reviewed, UniProtKB/Swiss-Prot Q752H4 (MPG1_ASHGO)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

Name:	MPG1
Ordered Locus Names:	AFR599W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Mannose-1-phosphate guanyltransferase		PRO_0000238482

Sequences

	Sequence		Length	Mass (Da)
	Q752H4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DDD45BC04BC70AFC	FASTA	361	39,471
	10 20 30 40 50 60 MKGLILVGGY GTRLRPLTLT VPKPLVEFCN RPMILHQIEA LAAAGVTDIV LAVNYRPEVM 70 80 90 100 110 120 VETLKKYEKQ YGVSITFSVE TEPLGTAGPL KLAEKVLKKD NSPFFVLNSD VICEYPFKEL 130 140 150 160 170 180 AAFHRAHGGK GTIVATKVDE PSKYGVIVHD IATPNLIDRF VEKPVEFVGN RINAGLYILN 190 200 210 220 230 240 PEVIDLIELR PTSIEKETFP ILVEQKSLYS FDLEGYWMDV GQPKDFLAGT VLYLNSLSKR 250 260 270 280 290 300 HPEQLAKGDN IVGNVIIDPS AKISGSAKLG PDVVIGPNVT IGEGVRITRS VVLSDSTIND 310 320 330 340 350 360 HSLVKSTIVG WHSTVGKWCR LEGCSVLGDD VEVKDEVYVN GGKVLPHKSI SANVPKEAII M

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016819 Genomic DNA. Translation: AAS53970.1.
RefSeq	NP_986146.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q752H4.
Genome annotation databases
GeneID	4622430.
GenomeReviews	Gene locus AFR599W in contig AE016819_GR.
KEGG	ago:AGOS_AFR599W.
NMPDR	fig|33169.1.peg.3791.
Organism-specific databases
AGD	AFR599W.
Phylogenomic databases
HOGENOM	Q752H4.
OMA	RRIQLQP.
Enzyme and pathway databases
BRENDA	2.7.7.13. 279361.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG1_ASHGO

Accession

Primary (citable) accession number: Q752H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)