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Protein

Sterol 3-beta-glucosyltransferase

Gene

ATG26

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside (By similarity).By similarity

Catalytic activityi

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Autophagy, Lipid biosynthesis, Lipid metabolism, Protein transport, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 3-beta-glucosyltransferase (EC:2.4.1.173)
Alternative name(s):
Autophagy-related protein 26
Gene namesi
Name:ATG26
Ordered Locus Names:AFR681W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VI

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12271227Sterol 3-beta-glucosyltransferasePRO_0000215606Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ751Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 22942GRAM 1Add
BLAST
Domaini239 – 342104PHPROSITE-ProRule annotationAdd
BLAST
Domaini602 – 66867GRAM 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi436 – 49156Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated
Contains 2 GRAM domains.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000034145.
InParanoidiQ751Z4.
KOiK05841.
OMAiEATHSER.
OrthoDBiEOG7CK3GM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 2 hits.
PF00169. PH. 1 hit.
PF00201. UDPGT. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q751Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKGQKEGEA EPVPEGDKSG AGSSPSGVRK GLRVPLGLVS HSFSSLAKHK
60 70 80 90 100
EAERRLTDEE ESLSSPQDRE DDAASPNIMA KSIAGLLTTA SMYVGIGDIH
110 120 130 140 150
RAEQLATGQP ETDAGADETE DEMDEAGDET GDDADAPATG TDGEEESRPV
160 170 180 190 200
SAQESRRSTL FELSIEPHPE SHTAQASRTK NRRSRMTSKL RSKFNLDDDE
210 220 230 240 250
ELVREYPCWL LRDVLIQGHI YLTSRNLLFF AFLYKSNGSA RLTGNLSICN
260 270 280 290 300
NGLSISGISG KPTRYWTVLK DHTLSLYSSS TDLYFPVLTI DLRYVTKVQH
310 320 330 340 350
CKNNGKDTRQ FHITTESKTY TFYSDNEHSA RSWSSALKKQ VFATQNSDND
360 370 380 390 400
SMSVRIPLSN IIDVEEQAIV EQGLTLRVRV MESSDSFALD DYFFMFFNNA
410 420 430 440 450
GSQLKELIQI QVANLEMLGA ANVDYARHPL PPDTEASLPA VASDAAPQDA
460 470 480 490 500
AIASEAAADA AAADTASHSP STNAEPRARG RSTERAMAAS AYLFGRLTSP
510 520 530 540 550
RRDDAKQLSP SKVKLRFRSV ADTLKLTTPR QPGSDAPQEP EPETTILESR
560 570 580 590 600
PRLNYWSPRP FTTMRSMWNA QPVHYAAKGM SLFADDDELM IGDEAELLAA
610 620 630 640 650
DKRFKAHFSL TDDESLVASY YTYLNRSMPL YGKIYLGKTI MCFRSLLPGS
660 670 680 690 700
KTKMILPLHD VENCYKEQGF RFGYFGLVVV IYGHEELFFE FASQKSRDDA
710 720 730 740 750
EYVILKIIDS LKPVDGVMAD DMSAGAYSLK AAQGRDATTD AKVKLFEQRI
760 770 780 790 800
SSVGYDIPIM VEDNPFYKTT ITPKKFYTFG MLTIGSRGDV QPYIALGKGL
810 820 830 840 850
LQEGHRVVVI SHAEFGDWVR SHGLQFRAIA GDPAELMALM VQHGSMNVGL
860 870 880 890 900
IREAASTFRN WIRDLLETAW EACQGIDVLI ESPSAMAGIH IAEALQIPYF
910 920 930 940 950
RAFTMPWTKT RSYPHAFIVP DQKRGGNYNY FTHVLFENIF WKGINSQVNR
960 970 980 990 1000
WRVEKLGLKK TNLEFMQQGK VPFLYNMSPT VFPPSVDFAE WIKVTGYWFL
1010 1020 1030 1040 1050
NESSNYVPPQ ALLEFMAKAR RLDKKLVYIG FGSIVVKDPV KMTMAVVEAV
1060 1070 1080 1090 1100
VKADVYCILN KGWSARLGGQ SQKSIEVQLP NCVYDAGNVP HDWLFPRVDA
1110 1120 1130 1140 1150
AVHHGGSGTT GATMRAGVPT VIKPFFGDQY FYANRIEDIG AGIALRKLNA
1160 1170 1180 1190 1200
CTLSRALKEV TTNTRIIAKA KKIGQDISKE DGVATAIAFI YSEMAYAKSL
1210 1220
IKAKRQEDKK AAKEAKQIQN EDSWLLL
Length:1,227
Mass (Da):136,399
Last modified:January 9, 2013 - v2
Checksum:i8AD3965B13219B9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS54053.2.
RefSeqiNP_986229.2. NM_212365.2.

Genome annotation databases

EnsemblFungiiAAS54053; AAS54053; AGOS_AFR681W.
GeneIDi4622518.
KEGGiago:AGOS_AFR681W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016819 Genomic DNA. Translation: AAS54053.2.
RefSeqiNP_986229.2. NM_212365.2.

3D structure databases

ProteinModelPortaliQ751Z4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS54053; AAS54053; AGOS_AFR681W.
GeneIDi4622518.
KEGGiago:AGOS_AFR681W.

Phylogenomic databases

HOGENOMiHOG000034145.
InParanoidiQ751Z4.
KOiK05841.
OMAiEATHSER.
OrthoDBiEOG7CK3GM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 2 hits.
PF00169. PH. 1 hit.
PF00201. UDPGT. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 353.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiATG26_ASHGO
AccessioniPrimary (citable) accession number: Q751Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 9, 2013
Last modified: January 20, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.