Reviewed, UniProtKB/Swiss-Prot Q751J3 (ATM_ASHGO)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase TEL1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase TEL1
    Telomere length regulation protein 1
    ATM homolog

Gene names

Name:	TEL1
Ordered Locus Names:	AGL287W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	2768 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Associates with DNA double-strand breaks By similarity.
Subcellular location	Nucleus By similarity. Telomere By similarity. Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Chromosomal protein Nucleus Telomere
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2768	2768	Serine/threonine-protein kinase TEL1		PRO_0000227695
Regions
	Domain	1702 – 2308	607	FAT
	Domain	2443 – 2768	326	PI3K/PI4K
	Domain	2736 – 2768	33	FATC
	Coiled coil	2141 – 2204	64	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q751J3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5D6F08B3DDF04F95	FASTA	2,768	315,374
	10 20 30 40 50 60 MEQYVASAIN LLSSPKLKER SQALTDVAAI VKDNPDTLTS KSVGALVQSL IDILDAETRK 70 80 90 100 110 120 FDELCRRRPE AGARVELAQG RLNSVVAVLR LVLETIPDRL RAKQFRGLVL SLPELLGWAI 130 140 150 160 170 180 REQVHDMLQP LSACLQALTE CHTFKLKVDD GQWRTLVRAS AEDLVALFGI NCTHKSIAKL 190 200 210 220 230 240 AGALTSLIRM DAVGFKDVCE ELLLIPVRYY QNTDKETANM RSILQLCNLL VLKGHLIKFH 250 260 270 280 290 300 GVQYLIHCTM QHLLQFTLPG TDYILEEIAV FTLFSAELMI HEVPYIPGDL ESGRYFGKEV 310 320 330 340 350 360 LSELYQQFIV HLLENYRPQK LQLKDLEYRL LLDRRQWYQL DDFQISPHAS HIEWLQLQGI 370 380 390 400 410 420 SNMLCSYYAF QHRHPVMDIS QVKRRRLSDT YNSFLLNSQY GISFATSCID SNPVSSQLLG 430 440 450 460 470 480 LQLAACVTSF HECPKYQLEE LLDAILRRFE NANLVGWCCL AMLPLCSQLD LVISETVLQK 490 500 510 520 530 540 LLKLTLPLLK IPTLSAVASA LISKLLDYQQ RTLTGSNMLQ QCYDLYELSD IIGPAVVSNE 550 560 570 580 590 600 SFRLWQSLHI YGGDFRGKDG SSAADRIANW LFAKLNTVSP LDESQNSFPH FLGWLAGCQL 610 620 630 640 650 660 KDAYEVNRAI HVNSYCLEWE YTSVERTFLL SIETSRRLSR NRTTPLQNMN YESSSISELF 670 680 690 700 710 720 YRILDKITSQ DDIEAYGWMC FGLQLIHHIR ELTYLVEYVN DLKKAICLRL GKMNFGNSQI 730 740 750 760 770 780 LLSCIRQTTS LPSCDILPLF FTEREIANII YTYKELKLTE VPEGPAEDDF AGPAKARHKL 790 800 810 820 830 840 YPLNHLYAGK QGFEIDYVVS FIIMCSDYET NGDAAEKVIE LFLQLARSLP TNLIFQALPT 850 860 870 880 890 900 LITYIGSNDR ENISEDTLLA LTEFTGSSLL TNEYNTSTLS ITYLSLFLKS ISRYWLSDTH 910 920 930 940 950 960 MPSLTADCND ILEWIFSRLG DSSCIGCEAI MAILDMTLHM LKNYNRSNSK FTFDKQHLFH 970 980 990 1000 1010 1020 VLTTCLGRLP KFYICKVVHE LNSYVVRLGL KNQSIIFSEF AGLFDPPQRD AETAAYYSLT 1030 1040 1050 1060 1070 1080 LAGLGTISHM HLSNAILHVL PNLQHKHVSQ YALSFLKSVA GFHKLSGIRA LFHLCRFEIL 1090 1100 1110 1120 1130 1140 DIWSNKCAGL RDFSPIWNTA IFQFESFEQF INEYKHEVAA YYFAKLSPYH YLKSTLVNDD 1150 1160 1170 1180 1190 1200 KELPQLLEIS LQYAIPLAYI PGGIGDAIFD ICADQWSATN HTNVLKQQYL LIFDRLLHFA 1210 1220 1230 1240 1250 1260 DLTVFMEYFE SLQKVYTNSE LIHKMKKYTY NLHPKHLLSY SLRTALKVIH SKVLLGKLSI 1270 1280 1290 1300 1310 1320 QELRFLLTLN LQYLQESTLP DDRSQILRKI QIILVAYEQQ LEDASSVSDL LEILTDYLDD 1330 1340 1350 1360 1370 1380 PLLGNEVGAL IGSIVALGFN VKYTESLFLC IFAKLLPQLH EAKTANLSIL LNDISNTLTI 1390 1400 1410 1420 1430 1440 NNSNIIHGKW WHACIDALAG TSLFENTIYH DDSLLDTELL DHRALNLYSE ILSFLPPFTG 1450 1460 1470 1480 1490 1500 FPPNFVPKER VLRHLISQTT TFKLHDNFLL WKGHYIGMYH KFHGTIPQLA PNGPNQKLSI 1510 1520 1530 1540 1550 1560 DKLVKNYGLL NGIFELLEAI EKTTHARIKF ICQCINAVSL SHKDSLSTFT ADTQQFFGQL 1570 1580 1590 1600 1610 1620 SSKSVPLDLA LFFYMFPISN PSESMETFCR LHYPALTSDY SSWLVKLTMF ALDMLGRYIP 1630 1640 1650 1660 1670 1680 VVKCFEVLAT AITSRVEQLL NYWLLLLLYC DPNNGIRLLC TLISNIGLLK STKEGILKIK 1690 1700 1710 1720 1730 1740 YMLNLLLIVR SFHKLGYKEF DTIYDRISLQ DAYKVAAEVG EKYIACLLFE EFHMPNLARL 1750 1760 1770 1780 1790 1800 DVTYMKEIYK QFDDVDMIYG IPTTASLASA IELINQTQAT SLKSFMMNNG NFDAQYATHF 1810 1820 1830 1840 1850 1860 TGNIGNLVNS ASNNGFTGLA YALQNISSSK NTSATYNWCI ELDKWDLPTP DILDSTAKSI 1870 1880 1890 1900 1910 1920 YSIIKKTDIN TGTAEAAFKS TMLNALQFLE KTGVNEDNVS QLGSIVTMVQ LYNNNAEKLV 1930 1940 1950 1960 1970 1980 KSLHAQDRKI LKVKDFNDYY MDIKVRHVFL DHLIDSHKNR LSEEQSICLR FASICELSHL 1990 2000 2010 2020 2030 2040 SEVARGASDF QRSLDAVLLL EKSVLALPTN SSVEHYGLFK TFARRMSTIQ SAKMLWSQNE 2050 2060 2070 2080 2090 2100 TVMSIDMLKD LLHTPLSSNL IARARKQPFF QQMAILDINV KAQLVQWLSH SRQDVPERIF 2110 2120 2130 2140 2150 2160 KNYIGTSLQD IENYGDNPSR TEIVHTFGKF CYDQAKRFSE TNEVDIMARR VSKNKEELAA 2170 2180 2190 2200 2210 2220 LYQLYHDRSL PERERKEAKR HYARLLVRNQ QETETYNQLR DQRELFVTNA LLFFTQTLQY 2230 2240 2250 2260 2270 2280 DDLYDGEVID QFCGLWFEYS NDDNVSGKLL SNLQNIPEYK LLPWINQMAS KLADDESPFQ 2290 2300 2310 2320 2330 2340 KTLRAAMVRI LLKLPYDSLY VLIGMSLTGS RQNAKDSGSQ SRLVAVESLL KEVSKHDYGS 2350 2360 2370 2380 2390 2400 YATKYLLPVR EFCEMSVSLA SQKFAQNTRK IHLNNLKIGT YWLKELKGRK LPLPTAQSRV 2410 2420 2430 2440 2450 2460 SDRCGNSVSR SYITQVDPDV RIASSGLSLP KIVTFTLSDG TRHRALLKAG NDDLRQDAIM 2470 2480 2490 2500 2510 2520 EQVFKQVNKI LTSNKRTRKL KLRIRTYEVI PLGPQAGIIE FAPNSKSLHE ILAGYHKDDT 2530 2540 2550 2560 2570 2580 ISLEQARKAM KAVQGKSKEQ RIAVYVKITE SVKPVLRNFF YETFLDPEEW LLAKATYTKG 2590 2600 2610 2620 2630 2640 VVTNSIVGHI LGLGDRHLNN ILLDKFTGEP IHIDLGVAFD QGKLLPLPEL VPFRLTRDIV 2650 2660 2670 2680 2690 2700 DGFGVMGVEG LFRKNCEKVY GLLRKERERV MCVLNVLKWD PLYSWKMTPL RRQKLQGKLV 2710 2720 2730 2740 2750 2760 DGDSPSDSLV TSLPDSSDND ESRRALKGVE DKLLGNGLSV EATVQELVHR ATDVSNLAVI FMGWSPFY

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016820 Genomic DNA. Translation: AAS54204.1.
RefSeq	NP_986380.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4622673.
KEGG	ago:AGOS_AGL287W.
NMPDR	fig|33169.1.peg.4025.
Organism-specific databases
AGD	AGL287W.
Phylogenomic databases
HOGENOM	Q751J3.
Enzyme and pathway databases
BRENDA	2.7.11.1. 279361.
Family and domain databases
InterPro	IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHER	PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit.
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM_ASHGO

Accession

Primary (citable) accession number: Q751J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)