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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei195ATPPROSITE-ProRule annotation1
Active sitei298Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 99ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:AGL249C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VII

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129321 – 581Serine/threonine-protein kinase SSN3Add BLAST581

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi33169.AAS54242

Structurei

3D structure databases

SMRiQ751F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 475Protein kinasePROSITE-ProRule annotationAdd BLAST391

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 42Poly-Gln6
Compositional biasi549 – 557Poly-Ala9
Compositional biasi567 – 572Poly-Ser6

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ751F5
KOiK02208
OMAiIMWQILD
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q751F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIRLQSSDS MNNQHQTQQN KYFNVSNQAS TRSLWSQQQQ QQLLDTKGSA
60 70 80 90 100
STSKSPMLMA NNNVFSIGPY RQRKDAGRVS VLEKYEIIGY IAAGTYGKVY
110 120 130 140 150
KAKAKETQEE QENSIHTHNQ TLGSVSVAGI DGGMASREVE NGGDDPLRLD
160 170 180 190 200
GHGGIAVAPA AGGGLSSAAA HRARSNGAVK ALPKKSAFTP FYAIKKFKTE
210 220 230 240 250
REGVEQLHYT GISQSACREM SLCRELDNKH LTKLVEIFLE RKSIYMVSEF
260 270 280 290 300
AEHDLLQIIH FHSHPEKRLI APRMLKSIMW QILDGVSYLH QNWILHRDLK
310 320 330 340 350
PANIMVTVDG CVKIGDLGLA RKFYNLVQTL YTGDKVVVTI WYRAPELLLG
360 370 380 390 400
ARHYSPAIDL WAVGCIFAEL IGLRPIFKGE EAKMDSKKSV PFQGNQLQRI
410 420 430 440 450
LEVLGTPTHH TWPNIHKYPE YEQLSKFSKY RDNLSVWYHS SGGRDKAALS
460 470 480 490 500
LLYSLLKYDP ITRIDAIDAL EHEYFTNNDP PVSSDVFEGL SYKYPPRRIH
510 520 530 540 550
TSDNDIMNVG ANKNKSGFNH HPPQQQTVNN NGVTNSSIGG LGVNRRILAA
560 570 580
AAAAAAAVQV NGTNIVSGSS SSNGPIRKKK R
Length:581
Mass (Da):64,530
Last modified:January 9, 2013 - v2
Checksum:i11B88D39F280B640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA Translation: AAS54242.2
RefSeqiNP_986418.2, NM_211480.2

Genome annotation databases

EnsemblFungiiAAS54242; AAS54242; AGOS_AGL249C
GeneIDi4622711
KEGGiago:AGOS_AGL249C

Similar proteinsi

Entry informationi

Entry nameiSSN3_ASHGO
AccessioniPrimary (citable) accession number: Q751F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2013
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health