Q750Y8 (TPIS_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase

Gene names

Name:	TPI1
Ordered Locus Names:	AGL201C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Triosephosphate isomerase		PRO_0000090156
Sites
	Active site	95	1	Electrophile By similarity
	Active site	165	1	Proton acceptor By similarity
	Binding site	10	1	Substrate By similarity
	Binding site	12	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q750Y8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F9F69F4E4A80A71E	FASTA	248	26,782
	10 20 30 40 50 60 MARTFFVGGN FKLNGSKQSI KEIVERLNTA DLADNVEVVI CPPATYLDHA VSLVSHPQVT 70 80 90 100 110 120 VGAQNAYTKA SGAYTGENSV DQIKDVGAKW VILGHSERRT YFNEDDEQVA EKTAFALERG 130 140 150 160 170 180 VSVILCIGET LDEKKAGVTL DVVKRQLTPV LEKVKDWTNV VIAYEPVWAI GTGLAATAED 190 200 210 220 230 240 AQDIHAAIRD FLAERTSRDV ADAVRILFGG SANGANAASF RDKADVDGFL VGGASLKPEF VDIINSRR

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016820 Genomic DNA. Translation: AAS54290.1.
RefSeq	NP_986466.2. NM_211528.2.
3D structure databases
ProteinModelPortal	Q750Y8.
SMR	Q750Y8. Positions 2-247.
ModBase	Search...
Protein-protein interaction databases
STRING	Q750Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4622759.
GenomeReviews	Gene locus AGL201C in contig AE016820_GR.
KEGG	ago:AGOS_AGL201C.
NMPDR	fig|33169.1.peg.4111.
Organism-specific databases
AGD	AGL201C.
Phylogenomic databases
eggNOG	fuNOG04390.
HOGENOM	HBG708281.
OMA	VCVGETQ.
OrthoDB	EOG479JH2.
PhylomeDB	Q750Y8.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_ASHGO

Accession

Primary (citable) accession number: Q750Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program