Q750T7 (ACS2_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2

Gene names

Name:	ACS2
Ordered Locus Names:	AGL148C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	687 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 687	687	Acetyl-coenzyme A synthetase 2		PRO_0000208404

Sequences

	Sequence		Length	Mass (Da)
	Q750T7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E7099F544E8F77C7	FASTA	687	75,369
	10 20 30 40 50 60 MSCKEHKVVH EAHNVEARKT PDHFYRSQPG PSYVQDIEQY RTMYQQSIED PDAFFGEKAR 70 80 90 100 110 120 EFLHWEKDFT HVRAGSLRTG DTAWFLNGEL NAAYNCVDRH ALENPDKVAI IYEADDEADN 130 140 150 160 170 180 RVVTFGELLR QVSQVAGVLQ SWGVKKGDTV AVYMPMIPEA VVAMLAVARL GAVHSVIFAG 190 200 210 220 230 240 FSSGSLRDRI VDAESKVVIT CDEGRRGGKT VHTKKIVDEG LAGVGVVSHI LVFQRTGSEG 250 260 270 280 290 300 IPMKAGRDFW WHEEVRKQRG YLPPVSVNAE DPIFLLYTSG STGSPKGVVH TTGGYLLGAA 310 320 330 340 350 360 LTTRYVFDIH PEDVLFTAGD VGWITGHTYA LYGPLCLGTA TIIFESTPAY PDYGRYWRII 370 380 390 400 410 420 QRHKATHFYV APTAMRLIKT VGEQEISKYD LSSLRVLGSV GEPIAPDLWE WYNEKVGNNN 430 440 450 460 470 480 CVVCDTMWQT ESGSHLIAPL AGAIPTKPGS ATVPFFGINA CIIDPVTGDE LEGNDVEGVL 490 500 510 520 530 540 AIKSPWPSMA RSVWNNHDRY IETYLKPYPG YYFTGDGAGR DHDGYYWIRG RVDDVVNVSG 550 560 570 580 590 600 HRLSTAEIEA ALSEHEGVSQ AAVVGIADEL TGQAVVAFVS LKEGYGRGSS TDTDPESIAP 610 620 630 640 650 660 DVVPLDTLRR ELVLQVRAEI GPFAAPKSVI VVDDLPKTRS GKIMRRTLRK ISANEADQLG 670 680 DLSTLANPET VPAIIAAVGA QFLKGKK

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016820 Genomic DNA. Translation: AAS54343.1.
RefSeq	NP_986519.1. NM_211581.1.
3D structure databases
ProteinModelPortal	Q750T7.
SMR	Q750T7. Positions 38-655.
ModBase	Search...
Protein-protein interaction databases
STRING	Q750T7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4622812.
GenomeReviews	Gene locus AGL148C in contig AE016820_GR.
KEGG	ago:AGOS_AGL148C.
NMPDR	fig|33169.1.peg.4164.
Organism-specific databases
AGD	AGL148C.
Phylogenomic databases
eggNOG	fuNOG05220.
HOGENOM	HBG547964.
OMA	DYWWHEE.
OrthoDB	EOG4M0J8W.
PhylomeDB	Q750T7.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS2_ASHGO

Accession

Primary (citable) accession number: Q750T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program