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Q74ZR2

- PP4C_ASHGO

UniProt

Q74ZR2 - PP4C_ASHGO

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Manganese 1By similarity
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi81 – 811Manganese 1By similarity
Metal bindingi81 – 811Manganese 2By similarity
Metal bindingi113 – 1131Manganese 2By similarity
Active sitei114 – 1141Proton donorBy similarity
Metal bindingi163 – 1631Manganese 2By similarity
Metal bindingi237 – 2371Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:AGR136W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome VII

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000223649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei310 – 3101Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

Protein-protein interaction databases

STRINGi33169.AGOS_AGR136W.

Structurei

3D structure databases

ProteinModelPortaliQ74ZR2.
SMRiQ74ZR2. Positions 5-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ74ZR2.
KOiK15423.
OMAiNDISMIC.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74ZR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGMQLDEII EYLRYSKHIP EETIYELCLK CQELLVNESN VTHVDTPVTI
60 70 80 90 100
CGDIHGQLHD LLTLFEKSEG IEKNRFIFLG DFVDRGFYSL ESFLLLLCYK
110 120 130 140 150
LRYPDRITLI RGNHETRQIT KVYGFYDEVI RKYGNSNVWR YCCEVFDYLS
160 170 180 190 200
LGAIINGQIF CVHGGLSPDV MTVDEIRSID RKQEVPHEGA MCDLLWSDPD
210 220 230 240 250
EVDTWSLSPR GAGFLFGKNE VDQFLHRNDI SLIARAHQLV MEGYKEMFDG
260 270 280 290 300
GLVTVWSAPN YCYRCGNVAA VLRIDDDLSR NYTIFEAVPA QDNRGNAIIP
310
TKKPQMDYFL
Length:310
Mass (Da):35,699
Last modified:October 11, 2004 - v2
Checksum:i1B54B7CC11AF3975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA. Translation: AAS54626.2.
RefSeqiNP_986802.2. NM_211864.2.

Genome annotation databases

EnsemblFungiiAAS54626; AAS54626; AGOS_AGR136W.
GeneIDi4623104.
KEGGiago:AGOS_AGR136W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA. Translation: AAS54626.2 .
RefSeqi NP_986802.2. NM_211864.2.

3D structure databases

ProteinModelPortali Q74ZR2.
SMRi Q74ZR2. Positions 5-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AGR136W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS54626 ; AAS54626 ; AGOS_AGR136W .
GeneIDi 4623104.
KEGGi ago:AGOS_AGR136W.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
InParanoidi Q74ZR2.
KOi K15423.
OMAi NDISMIC.
OrthoDBi EOG7FFN29.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiPP4C_ASHGO
AccessioniPrimary (citable) accession number: Q74ZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3