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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:AGR136W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VII

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236491 – 310Serine/threonine-protein phosphatase 4 catalytic subunitAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

Protein-protein interaction databases

STRINGi33169.AAS54626

Structurei

3D structure databases

ProteinModelPortaliQ74ZR2
SMRiQ74ZR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696
InParanoidiQ74ZR2
KOiK15423
OMAiPDRMTLI
OrthoDBiEOG092C2R40

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q74ZR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMQLDEII EYLRYSKHIP EETIYELCLK CQELLVNESN VTHVDTPVTI
60 70 80 90 100
CGDIHGQLHD LLTLFEKSEG IEKNRFIFLG DFVDRGFYSL ESFLLLLCYK
110 120 130 140 150
LRYPDRITLI RGNHETRQIT KVYGFYDEVI RKYGNSNVWR YCCEVFDYLS
160 170 180 190 200
LGAIINGQIF CVHGGLSPDV MTVDEIRSID RKQEVPHEGA MCDLLWSDPD
210 220 230 240 250
EVDTWSLSPR GAGFLFGKNE VDQFLHRNDI SLIARAHQLV MEGYKEMFDG
260 270 280 290 300
GLVTVWSAPN YCYRCGNVAA VLRIDDDLSR NYTIFEAVPA QDNRGNAIIP
310
TKKPQMDYFL
Length:310
Mass (Da):35,699
Last modified:October 11, 2004 - v2
Checksum:i1B54B7CC11AF3975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA Translation: AAS54626.2
RefSeqiNP_986802.2, NM_211864.2

Genome annotation databases

EnsemblFungiiAAS54626; AAS54626; AGOS_AGR136W
GeneIDi4623104
KEGGiago:AGOS_AGR136W

Similar proteinsi

Entry informationi

Entry nameiPP4C_ASHGO
AccessioniPrimary (citable) accession number: Q74ZR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health