Reviewed, UniProtKB/Swiss-Prot Q74ZL1 (KAD1_ASHGO)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
Ordered Locus Names:	AGR187W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Adenylate kinase 1		PRO_0000365658
Regions
	Nucleotide binding	69 – 77	9	ATP By similarity
	Nucleotide binding	92 – 121	30	AMP By similarity
Sites
	Binding site	93	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q74ZL1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1A494DBD262EC407	FASTA	277	30,283
	10 20 30 40 50 60 MSCWTYLGRA RGPRASAPTA RRFFANFFND LIVAVSSTVG ALKTSQQTPL KMSQDMSHVP 70 80 90 100 110 120 EAIRMVLIGP PGAGKGTQAP KLKEKFCVCH LATGDMLRSQ VAKQTALGVQ AKKIMDQGGL 130 140 150 160 170 180 VSDEIMVNMI KDELRSNPEC ANGFILDGFP RTIPQAQKLD EMLVAQGKPL DRAVELKIDD 190 200 210 220 230 240 ELLVARITGR LVHPASGRSY HKLFNPPKVA MTDDVTGDPL VQRSDDNADA LKKRLDAYHA 250 260 270 QTEPIVDFYK KTGIWAGVDA SQPPKTVWSD ILKALGK

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016820 Genomic DNA. Translation: AAS54677.1.
RefSeq	NP_986853.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKY based on UniProtKB P07170.
SMR	Q74ZL1. Positions 61-277.
ModBase	Search...
Protein-protein interaction databases
STRING	Q74ZL1.
Genome annotation databases
GeneID	4623155.
GenomeReviews	Gene locus AGR187W in contig AE016820_GR.
KEGG	ago:AGOS_AGR187W.
NMPDR	fig|33169.1.peg.4498.
Organism-specific databases
AGD	AGR187W.
Phylogenomic databases
HOGENOM	Q74ZL1.
OMA	GRSYHKE.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_ASHGO

Accession

Primary (citable) accession number: Q74ZL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)