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Protein

Protein N-methyltransferase NNT1

Gene

NNT1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase. Involved in rDNA silencing and in lifespan determination.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei115 – 1151S-adenosyl-L-methionineBy similarity
Binding sitei152 – 1521S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei176 – 1761S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-methyltransferase NNT1By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Nicotinamide N-methyltransferase-like protein 1By similarity
Gene namesi
Name:NNT1
Ordered Locus Names:AGR284W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome VII

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Protein N-methyltransferase NNT1PRO_0000096889Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ74ZB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 953S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. NNT1 family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ74ZB5.
KOiK17878.
OMAiLVFYTHH.
OrthoDBiEOG7JHMGG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74ZB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDHEEDSL YGATELFGEP DGFYEKPAES HFAEYERSAV PAQSARRDTQ
60 70 80 90 100
VRIRLVGSSP LWGHLLWNSA IYTARHLDAH PEQVVGRCVL ELGAAGALPS
110 120 130 140 150
LVAGLLGARQ VVATDYPDAD LVGNIQYNVD HVIYGGKPPT EAPHVAVEGY
160 170 180 190 200
IWGNDYGPLR RHLPPGQTGF DLVLLSDLVF NHTEHHKLLQ TTRDLLAPAG
210 220 230 240 250
RALVVFSPHR PWLLEKDLQF FETAAEYGLR AELIEQVTWA PMFADDPGPA
260
EVRARVYAYY LTHCA
Length:265
Mass (Da):29,379
Last modified:July 5, 2004 - v1
Checksum:i606D6F1F87AFED1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA. Translation: AAS54774.1.
RefSeqiNP_986950.1. NM_212012.1.

Genome annotation databases

EnsemblFungiiAAS54774; AAS54774; AGOS_AGR284W.
GeneIDi4623252.
KEGGiago:AGOS_AGR284W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016820 Genomic DNA. Translation: AAS54774.1.
RefSeqiNP_986950.1. NM_212012.1.

3D structure databases

ProteinModelPortaliQ74ZB5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS54774; AAS54774; AGOS_AGR284W.
GeneIDi4623252.
KEGGiago:AGOS_AGR284W.

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ74ZB5.
KOiK17878.
OMAiLVFYTHH.
OrthoDBiEOG7JHMGG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiNNT1_ASHGO
AccessioniPrimary (citable) accession number: Q74ZB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.