Reviewed, UniProtKB/Swiss-Prot Q74ZB5 (NNT1_ASHGO)

Names and origin

Protein names

Recommended name:
    Putative nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:	NNT1
Ordered Locus Names:	AGR284W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Putative nicotinamide N-methyltransferase		PRO_0000096889

Sequences

	Sequence		Length	Mass (Da)
	Q74ZB5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 606D6F1F87AFED1A	FASTA	265	29,379
	10 20 30 40 50 60 MSSDHEEDSL YGATELFGEP DGFYEKPAES HFAEYERSAV PAQSARRDTQ VRIRLVGSSP 70 80 90 100 110 120 LWGHLLWNSA IYTARHLDAH PEQVVGRCVL ELGAAGALPS LVAGLLGARQ VVATDYPDAD 130 140 150 160 170 180 LVGNIQYNVD HVIYGGKPPT EAPHVAVEGY IWGNDYGPLR RHLPPGQTGF DLVLLSDLVF 190 200 210 220 230 240 NHTEHHKLLQ TTRDLLAPAG RALVVFSPHR PWLLEKDLQF FETAAEYGLR AELIEQVTWA 250 260 PMFADDPGPA EVRARVYAYY LTHCA

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016820 Genomic DNA. Translation: AAS54774.1.
RefSeq	NP_986950.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q74ZB5.
Genome annotation databases
GeneID	4623252.
GenomeReviews	Gene locus AGR284W in contig AE016820_GR.
KEGG	ago:AGOS_AGR284W.
NMPDR	fig|33169.1.peg.4595.
Organism-specific databases
AGD	AGR284W.
Phylogenomic databases
HOGENOM	Q74ZB5.
OMA	VVFSPHR.
Enzyme and pathway databases
BRENDA	2.1.1.1. 279361.
Family and domain databases
InterPro	IPR019410. Methyltransferase-16_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_ASHGO

Accession

Primary (citable) accession number: Q74ZB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)